Depicted are "body weight change" (blue), "body weight gain" (red), and "change up to 50" (yellow)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative trait linkage analysis of longitudinal change in body weight"</p><p>http://www.biomedcentral.com/1471-2156/4/s1/S7</p><p>BMC Genetics 2003;4(Suppl 1):S7-S7.</p><p>Published online 31 Dec 2003</p><p>PMCID:PMC1866508.</p><p></p

Depicted are "body weight change" (blue), "body weight gain" (including the covariate age at first examination) (red), and "change up to 50" (yellow)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative trait linkage analysis of longitudinal change in body weight"</p><p>http://www.biomedcentral.com/1471-2156/4/s1/S7</p><p>BMC Genetics 2003;4(Suppl 1):S7-S7.</p><p>Published online 31 Dec 2003</p><p>PMCID:PMC1866508.</p><p></p

Mitochondrial genome-wide <i>P</i> values after adjusting for multiple testing.

<p>On the y axis, adjusted p-values transformed into the negative of the base 10 logarithm, −log₁₀(p-value), are shown. The x-axis represents the mitochondrial genome, displaying the position and relative size of each of the 13 major mitochondrial genes, 12S and 16S rRNAs, hypervariable region 1 (HVRI), hypervariable region 2 (HVR II) as well as the position of the 22 tRNAs (gray). The dashed lines show the critical values of the pointwise significance level corresponding to an FDR of 0.05.</p

Summary of significant mtSNPs.

<p>Genomic position in base pairs (bp), alleles, rs_number, and type of mutation are based on the NCBI dbSNP GRCh38 human genome assembly (rCRS, GeneBank ID J01415.2). Alleles are given in terms of major→minor allele. An estimated effect size (β_SNP)<0 indicates that the minor allele increases BMI. Nominal p-values and adjusted p-values are provided.</p

Comparison of , and .

<p>Comparison of , and .</p

Five empirical evaluations of the −log₁₀(<i>P</i>)-distribution of the statistic, each obtained by simulating 2 × 10⁹ replicates.

<p>The theoretical distribution was obtained by fitting a straight line. The grey shaded area reflects the 95% Clopper-Pearson confidence interval [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154872#pone.0154872.ref007" target="_blank">7</a>].</p

Coverage of the mitochondrial genome provided by each genotyping chip.

<p>Each vertical bar stands for one mtSNP. The x-axis represents the mitochondrial genome, displaying the position and relative size of each of the 13 major mitochondrial genes, 12S and 16S rRNAs, hypervariable region 1 (HVRI), hypervariable region 2 (HVR II) as well as the position of the 22 tRNAs.</p

Summary of the quality control.

<p>The number of <b>mtSNPs</b> refers to the SNPs that passed QC and were included in the analysis. Several mtSNPs were excluded due to the upper bound cut-off (<b>UB</b>) or because the basepair position was not available in Build 38 (<b>no_B38</b>). Sample size is based on the particular chip. One person may be present on more than one chip. <i>I_SNP</i> stands for the number of intensity measures per allele. <i>I_tot</i> represents the total number of intensity measures in the sample (I_SNP*2*sample-size*mtSNPs).</p

Distribution of characteristics of the study population.

<p>The mtSNPs column shows the number of mitochondrial SNPs provided by each chip. Distributions are presented as means ± standard deviation.</p

Distribution of the slope parameter <i>b</i> of simulated distributions by different simulation settings.

<p>sim. = simulations, repl. = replicates.</p