Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

GEOMETRIC MODELING AS A TOOL TO IMPROVE THE QUALITY OF GRAPHIC TRAINING OF STUDENTS

The article discusses the potential use of modern computer technology in the framework of geometrical graphic training students at the Technical University. Examples of solving problems of geometric modeling based on the basic provisions of descriptive geometry and using instrumental possibilities of computer graphics

PRACTICAL IMPLEMENTATION OF STUDENT’S PROJECT-ORIENTED ACTIVITIES DURING GRAPHICAL TRAINING

In range of the education development conception during coming years, discusses the use of a method of projects and the potential of modern computer technology in the geometric-graphic training of students in technical higher education. Made the analysis of current design activity. Represented examples of practicaloriented problems of geometric modeling and design tasks performed by students in engineering graphics learning

Functional information technology in geometry-graphic training of engineers

In the last decade, information technology fundamentally changed the design activity and made significant adjustments to the development of design documentation. Electronic drawings and 3d-models appeared instead of paper drawings and the traditional form of the design documentation. Geometric modeling of 3d-technology has replaced the graphic design technology. Standards on the electronic models are introduced. Electronic prototypes and 3d-printing contribute to the spread of rapid prototyping technologies.In these conditions, the task to find the new learning technology, corresponding to the level of development of information technologies and meeting the requirements of modern design and manufacturing technologies, comes to the fore. The purpose of this paper — the analysis of the information technology capabilities in the formation of geometrical-graphic competences, happening in the base of graphic training of students of technical university. Traditionally, basic graphic training of students in the junior university courses consisted in consecutive studying of the descriptive geometry, engineering and computer graphics. Today, the use of integrative approach is relevant, but the role of computer graphics varies considerably. It is not only an object of study, but also a learning tool, the core base of graphic training of students. Computer graphics is an efficient mechanism for the development of students’ spatial thinking. The role of instrumental training of students to the wide use of CAD-systems increases in the solution of educational problems and in the implementation of project tasks, which corresponds to the modern requirements of the professional work of the designer-constructor.In this paper, the following methods are used: system analysis, synthesis, simulation.General geometric-graphic training model of students of innovation orientation, based on the use of a wide range of computer technology is developed. The implementation of this model is based on the functional characteristics analysis of the applied technology training. We describe the use of a complex system of information technology in various forms of training. This shows the options for the integration of these technologies in the content of the sections of the students’ graphic training, as well as the efficiency of their use.The materials can be used to optimize the learning process in technical universities both in the graphic training and other subject areas

PROJECTS METHOD IN ORGANIZING OF GRAPHICAL TRAINING

The article discusses the design-targeted approach in higher professional education, especially in subject training. This urgent problem is indicated in the Program of Education Development in the Russian Federation in the years 2016-2020. The authors represent an analysis of innovations that accompany projecting-engineering activity, including using of up-to-date design technologies within the scope of the basic graphical training of students. Thepaper analyzes the possibility of usingthe project method and design technologies in teaching first-and-second-year students. The represented educational technologies have various levels of immersion in the project activities applied in teaching graphical disciplines at Perm National Research Polytechnic University. The need of system and consistent use of project method throughout the subject teaching is discussed. The need of individualization and variation in applied educational procedures is also substantiated

Profile Aspects of Graphic Education at Polytechnic University

Availability of qualified engineering personnel for high-tech industries is a topical problem today. To close the gap between the practice of polytechnic education and real engineering activities, it is necessary to introduce innovative educational technologies aimed at developing students’ ability to work in a team, competences in the field of modern information and communication technologies, as well as a willingness to carry out design based on spatial modeling.Within the framework of subject training, it is necessary to ensure the unity of fundamental (generalized, theoretical) knowledge and special knowledge corresponding to the profile of the training area. An appropriate construction of the training program contributes to the adaptation and concretization of subject competencies in the direction required for this engineering specialty.Graphic training is the first professionally oriented discipline at technical university. Within the framework of subject training, it is important to create a learning environment that is close to professional. The authors adduce the examples of educational tasks based on the method of projects and corresponding to the profile of the educational program that students perform in the course of self-directed work. An innovative aspect in the development of individual tasks is the ability to perform projects in 3d

Phylogeny and Classification of Yersinia pestis Through the Lens of Strains From the Plague Foci of Commonwealth of Independent States

The established phylogeny of the etiological agent of plague, Yersinia pestis, is not perfect, as it does not take into account the strains from numerous natural foci of Commonwealth of Independent States (CIS). We have carried out PCR and SNP typing of 359 strains and whole genome sequencing of 51 strains from these plague foci and determined the phylogenetic diversity of the strains circulating here. They belong to 0.ANT3, 0.ANT5, 2.ANT3, 4.ANT branches of antique biovar, 2.MED0, 2.MED1 branches of medieval biovar and to 0.PE2, 0.PE4a. 0.PE4h, 0.PE4t branches. Based on the studies of 178 strains from 23 plague foci of CIS countries, it was determined that the population structure of 2.MED strains is subdivided into Caucasian–Caspian and Central Asian–Chinese branches. In Central-Caucasian high-mountain plague foci in the Russian Federation (RF) the most deeply diverged branch of medieval biovar, 2.MED0, has been found. With the data obtained, the current population structure of Y. pestis species has been refined. New subspecies classification is developed, comprising seven subspecies: pestis, caucasica (0.PE2), angolica (0.PE3), central asiatica (0.PE4), tibetica (0.PE7), ulegeica (0.PE5), and qinghaica (0.PE10)

Table_4_Phylogeny and Classification of Yersinia pestis Through the Lens of Strains From the Plague Foci of Commonwealth of Independent States.XLSX

<p>The established phylogeny of the etiological agent of plague, Yersinia pestis, is not perfect, as it does not take into account the strains from numerous natural foci of Commonwealth of Independent States (CIS). We have carried out PCR and SNP typing of 359 strains and whole genome sequencing of 51 strains from these plague foci and determined the phylogenetic diversity of the strains circulating here. They belong to 0.ANT3, 0.ANT5, 2.ANT3, 4.ANT branches of antique biovar, 2.MED0, 2.MED1 branches of medieval biovar and to 0.PE2, 0.PE4a. 0.PE4h, 0.PE4t branches. Based on the studies of 178 strains from 23 plague foci of CIS countries, it was determined that the population structure of 2.MED strains is subdivided into Caucasian–Caspian and Central Asian–Chinese branches. In Central-Caucasian high-mountain plague foci in the Russian Federation (RF) the most deeply diverged branch of medieval biovar, 2.MED0, has been found. With the data obtained, the current population structure of Y. pestis species has been refined. New subspecies classification is developed, comprising seven subspecies: pestis, caucasica (0.PE2), angolica (0.PE3), central asiatica (0.PE4), tibetica (0.PE7), ulegeica (0.PE5), and qinghaica (0.PE10).</p