13 research outputs found
Exocytosis of a synapse visualized by simultaneous microscopy of Ca-imaging and DIC-imaging
Inhibition of ATP-evoked dopamine release by wortmannin, a myosin light chain kinase inhibitor
Studies on the involvement of ascendig serotonergic pathways in the pain suppressive system
Effects of long-term exposure to phorbol ester on secretory function in adrenal chromaffin cells
Spatio-Temporal Regulation of Neurotransmitter Release by PKC; Studies in Adrenal Chromaffin Cells
Exocytosis: The Chromaffin Cell As a Model System
Neurons and neuroendocrine cells release transmitters and hormones by exocytosis of secrctory vesicles or granules. Among the cell models that have provided insight into the molecular machinery underlying the successive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Thus, most of the molecular players that orchestrate the formation, targeting, docking, and fusion of secrctory granules have been identified in chromaffin cells. By offering the opportunity to combine the use of recent biophysical techniques allowing single-vesicle resolution and specific biochemical modifications in the protein machinery involved in exocytosis, chromaffn cells remain a powerful model to address new and still open questions in the field of secretion.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73603/1/j.1749-6632.2002.tb04461.x.pd