ПРИНЦИПИ УТВОРЕННЯ ПАРАМЕТРИЧНИХ ВУЗЛІВ КІНЦЕВОГО ПУНКТУ КЕРУЮЧОЇ СИСТЕМИ ТРАНСПОРТНОГО ЗАСОБУ, НЕУКОМПЛЕКТОВАНОГО АНТЕННОЮ ДЛЯ ПОЛЬОТУ

The principles of formation of the vector of distance D from unmanned aerial vehicle UAV to transponderbeacon,and its velocity V­­k, which are necessary for on board calculation of the UAV motion parameters.Показанны принципы формирования векторов дальности D от беспилотного летательного аппарата к маяку- ответчику,его скорость к V­­k, необходимые для вычисления на борту БПЛА параметров его движения.Показані принципи формування векторів дальності D від безпілотного літального апарату до маяка-відповідача ,та його швидкості V­­k , необхідної для обчислення на борту БПЛА параметра його руху

Phase transition in a mean-field model for sympatric speciation

We introduce an analytical model for population dynamics with intra-specific competition, mutation and assortative mating as basic ingredients. The set of equations that describes the time evolution of population size in a mean-field approximation may be decoupled. We find a phase transition leading to sympatric speciation as a parameter that quantifies competition strength is varied. This transition, previously found in a computational model, occurs to be of first order.Comment: accepted for Physica

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci

A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models. A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new modifier allele. New mutation rates survive if and only if they fall below this surface - a generalization of the hyperplane found by Zhivotovsky et al. (1994) for a multilocus recombination modifier. Increases in mutation rates at some loci may evolve if compensated for by decreases at other loci. The strength of selection on the modifier scales in proportion to the number of germline cell divisions, and increases with the number of loci affected. Loci that do not make a difference to marginal fitnesses at equilibrium are not subject to the reduction principle, and under fine tuning of mutation rates would be expected to have higher mutation rates than loci in mutation-selection balance. Other results include the nonexistence of 'viability analogous, Hardy-Weinberg' modifier polymorphisms under multiplicative mutation, and the sufficiency of average transmission rates to encapsulate the effect of modifier polymorphisms on the transmission of loci under selection. A conjecture is offered regarding situations, like recombination in the presence of mutation, that exhibit departures from the reduction principle. Constraints for tractability are: tight linkage of all loci, initial fixation at the modifier locus, and mutation distributions comprising transition probabilities of reversible Markov chains.Comment: v3: Final corrections. v2: Revised title, reworked and expanded introductory and discussion sections, added corollaries, new results on modifier polymorphisms, minor corrections. 49 pages, 64 reference

Significance of neutrophil flow cytometry in laboratory monitoring in coronary heart disease

The aim of the work is a comparative assessment of quantitative and functional parameters of blood neutrophils in patients with different forms of ischemic heart disease (IHD). In patients with acute myocardial infarction and IHD disease, the number of neutrophils, the content of myeloperoxidase in them by flow cytometry, the level of markers of myocardial damage in immunochemical tests were determined. An increase in the level of neutrophils, including band forms, with a decrease in the level of intracellular myeloperoxidase was established. These changes were more significant in acute myocardial infarction than in IHD. The correlation of the myeloperoxidase level with troponin concentration is shown. The study of peripheral blood neutrophils by flow cytometry with the determination of intracellular myeloperoxidase can be considered as an additional tool for laboratory diagnosis of ischemic heart disease.Цель работы — сравнительная оценка количественных и функциональных параметров нейтрофилов крови, определенных методом проточной цитометрии, у пациентов с разными формами ИБС. У пациентов с острым инфарктом миокарда и хронической ИБС определяли количество нейтрофилов и содержание в них миелопероксидазы методом проточной цитометрии, а также уровень маркеров повреждения миокарда в сыворотке крови. Установлено повышение уровня нейтрофилов, в том числе молодых форм с одновременным снижением уровня внутриклеточной миелопероксидазы. Эти изменения были более выражены при остром инфаркте миокарда, чем при хронической ИБС. Показана корреляционная связь содержания миелопероксидазы с концентрацией тропонина. Исследование нейтрофилов периферической крови методом проточной цитометрии с определением внутриклеточной миелопероксидазы может рассматриваться в качестве дополнительного инструмента лабораторной диагностики ИБС

Сравнительная оценка стандартного эхокардиографического исследования и классификационной модели на основе параметров функциональной геометрии левого желудочка в диагностике систолической дисфункции трансплантированного сердца

Objective. The purpose of this study was to assess the state of left ventricular (LV) systolic dysfunction for an extended period after heart transplantation using the parameters of the functional geometry of the left ventricle. Material and Methods. The study included 31 patients after orthotopic heart transplantation with a follow-up period of up to nine years. We used linear discriminant analysis to build a classification model based on either the standard echocardiographic parameters of LV systolic function or parameters of LV functional geometry indexes aimed at the potential prediction of acute rejection and progression of chronic heart failure. Results. The linear discriminant analysis model based on parameters of LV functional geometry showed a high predictive value to diagnose acute rejection and development of heart failure in heart transplant patients. Conclusion. Linear discriminant analysis classification model based on the LV functional geometry data showed high accuracy in predicting allograft rejection and development of heart failure in heart transplant patients. © 2022 Industrial Laboratory. Materials Diagnostics. All rights reserved.The work was carried out within the framework of state assignments for the Ural State Medical University of Minzdrav of Russia (theme № AAAA-A18-118051590064) and Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences (theme No AAAAA18-118020590031-8). This work was supported by Decree of the Russian Government №211 of March 16, 2013 (agreement 02.A03.21.0006)