Oncofertility care in young women and the outcomes of pregnancy over the last 5 years

Aim: To ascertain the actual outcomes of oncofertility care in young women to provide more appropriate care. Materials & methods: We analyzed the data of 67 female patients under 43 years of age who underwent oncofertility care between January 2015 and September 2019. Results: There were 28 patients with breast cancer, 19 patients with hematologic cancer and 20 patients with other cancer diagnoses. Breast cancer patients tended to take longer than hematologic cancer patients to initiate oncofertility treatment. Despite undergoing oncofertility care, seven of nine pregnant patients did not choose assisted reproductive technology (ART). Conclusion: As spontaneous pregnancies were more common than ART pregnancies in our study, pregnancy by not only ART but also non-ART method is a viable option for young cancer survivors

Impaired response of perforating arteries to hypercapnia in chronic hyperglycemia

Diabetes mellitus increases the risk of cerebrovascular disease, the effects ofhypercapnia on CBF (cerebral blood flow) and cerebrovascular reactivity duringdiabetes are still inconsistent. Here, we have established a new microangiographictechnique using synchrotron radiation (SPring-8, Japan), which enabled us to visualizerat cerebral vessels with high spatial resolution in real time. The goal of the studypresented here was to identify the effects of chronic hyperglycemia onhypercapnia-induced vascular responses (endothelium-dependent vasodilatation) andnitric oxide (NO) donor- induced vascular responses (endothelium-independent) ofperforating arteries and of the deeply located large cerebral arteries. We found asignificant vasodilatation of rat perforating arteries after hypercapnia with a maximumdiameter of approximately 140% of baseline in normal Wistar rats. Chronichyperglycemia impaired vasodilatation of perforating arteries in genetically diabeticGK rats. SNP (sodium nitroprusside) caused a similar vasodilatation of perforatingvessels in normal and chronic hyperglycemia, indicating that endothelium-dependentvasodilatation of perforating arteries may be specifically impaired in chronichyperglycemia. Possible impairment of endothelium-dependent vasodilatation inperforating vessels during chronic hyperglycemia may cause decreased vascularreserve capacity of perforating artery, resulting in the increased ischemic insults andcerebrovascular diseases in diabetes