Exploring Hidden Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus Admitted to Shinshu University Hospital

Using the event-triggered recorder, SpiderFlash-t AFIB, which allows us to detect asymptomatic or symptomatic arrhythmia, we examined the prevalence of hidden atrial fibrillation (AF) in patients with type 2 diabetes admitted to our hospital. In total, we enrolled 69 patients with type 2 diabetes mellitus admitted to the hospital due to hyperglycemia. Averages of HbA1c, age, duration of the disease, and BMI were 8.9 ％, 64.8 years old, 14.8 years, and 26.0 kg/m2, respectively. Neuropathy, retinopathy, and nephropathy were found in 37 (53.6 ％), 27 (39.1 ％), and 27 (39.1 ％), respectively. Macroangiopathy was found in 13 (18.9 ％). In the first series of surveys where we attached the recorder for 7 days no sustained AF events were found, and only 2 transient events. We attached the recorder for 14 days with 39 subjects in the second series of the survey, and fail to find any AF rhythm. This study is the first attempt to reveal the frequency of hidden AF in diabetes. This finding suggests that screening of atrial fibrillation with SpiderFlash-t AFIB for patients with type 2 diabetic patients hospitalized for glycemic control may not be useful in assessing the prevalence of atrial fibrillation.Article信州医学雑誌 69(2): 75-81(2021)departmental bulletin pape

Effect of amino acid mixtures on nasal allergic responses induced by toluene diisocyanate in mice

We studied the effect of various amino acid mixtures on nasal allergy induced by the intranasal application of toluene diisocyanate (TDI) in mice. In Experiment 1 (Exp. 1), mice were fed a 25% casein, soy protein isolate (SPI), egg white protein (EW) or gluten diet. In Experiment 2 (Exp. 2), mice were fed a 25% amino acid mixture diets patterned after casein (AA-casein), SPI (AA-SPI), EW protein (AA-EW) or gluten (AA-gluten). In Experiment 3 (Exp. 3) we modified the glutamine/glutamic acid (Gln/Glu) concentrations in the amino acid mixtures. Mice were fed a 25% AA-SPI, low Gln/Glu AA-SPI (LG-AA-SPI), AA-EW or high Gln/Glu AA-EW (HG-AA-EW) diet. At the 5th week, mice were divided into sensitized (sen-) and non-sensitized (ns-) groups. The mice in sensitized groups were treated with two courses of intranasal application of toluene diisocyanate (TDI) in ethyl acetate for 5 consecutive days, separated by 9 days rest. The non-sensitized groups of mice were treated with a vehicle. Nine days after the second sensitization, all mice were provoked by TDI. Nasal responses and serum IgE concentration were studied. The findings of Exp. 1 showed that the sen-EW group exhibited a lower body weight gain, higher nasal symptom score and higher IgE concentration than the other sensitized groups. The findings of Exp. 2 showed that the sen-EW group had a lower body weight gain, higher nasal symptom score and higher IgE concentration than the other sensitized groups. In Exp. 3, the AA-EW group showed a higher total nasal score and IgE concentration than the HG-AA-EW group, however, the findings of LG-AA-SPI and AA-SPI were similar. These findings demonstrated that amino acid mixtures affect nasal allergy induced by the intranasal application of TDI in mice

Oolong tea increases energy metabolism in Japanese females

Oolong tea is a traditional Chinese tea that has long been believed to be beneficial to health such as decreasing body fat. We were interested in this assertion and tried to evaluate the effect of oolong tea on energy expenditure (EE) in comparison with green tea. The subjects were eleven healthy Japanese females (age 20±1 y body mass index(BMI) 21.2±2.5kg/m2)who each consumed of three treatments in a crossover design : 1) water, 2) oolong tea, 3) green tea. Resting energy expenditure (REE) and EE after the consumption of the test beverage for 120 min were measured using an indirect calorimeter. The cumulative increases of EE for 120 min were significantly increased 10% and 4% after the consumption of oolong tea and green tea, respectively. EE at 60 and 90 min were significantly higher after the consumption of oolong tea than that of water (Plt0.05). In comparison with green tea, oolong tea contained approximately half the caffeine and epigallocatechin galate, while polymerized polyphenols were double. These results suggest that oolong tea increases EE by its polymerized polyphenols

看護学生における子宮頸がん検診行動の継続にかかわる動機

　【目的】本研究は, 青年期後期からの子宮頸がん検診啓発をめざし, 看護学生の子宮頸がん検診の継続にかかわる動機を探索した.【方法】A県内の看護大学・専門学校に在籍する学生293名に, 無記名自己記入式質問紙調査を行った. 子宮頸がん検診を動機づけるプロセスは, ノラJ. ペンダーの改定ヘルスプロモーションモデルを参考にした. 対象者を検診状況から「行動あり群」46名（15.7%）, 「継続群」17名（5.8%）, 「行動なし群」230名（78.5%）の3群に分けて分析した. 分析には, クラスカル・ウォリス検定, および，χ ₂ 検定を用いた.【結果】検診の利益の認識については, 3群全てが「早期発見の機会」, ｢早期治療の機会｣, ｢健康を考える機会｣と捉えていた. 検診イメージについては, 継続群は他群より｢安心な｣（H（2）=19.970,p<.001）, ｢のんびりした｣（H（2）=11.298,p=.004）, ｢幸福な｣（H（2）=8.081,p=.018）, ｢清潔な｣（H（2）=8.076,p=.018）というポジティブなイメージを持っていた. 検診の負担の認識については, 3 群全体で負担得点が高かった項目は「羞恥心がある」, ｢男性医師は嫌｣であった. また, 継続群は他群より「検査内容がわからず不安」（H（2）=38.175,p<.001）, ｢検診をうけたことを他人に知られたくない｣（H（2）=14.012,p=.001）という意識が低かった. さらに, 継続群は他群より有意に検診実行の自信（H（2）=50.447, p<.001）を持っていた. 検診実行の意志については継続群が行動なし群より有意に検診実行の意志を持っていた（H（2）=35.768,p<.001）.【結論】子宮頸がん検診の継続に関わる動機は, 検診に対する認識と感情に大きく影響されることが示された

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Defective mitochondrial quality control is shown to be a mechanism for neurodegeneration in some forms of Parkinson's disease