Облачные технологии в художественном предпринимательском образовании

The article explores the issue of active implementation of cloud technology in art education. A methodical designing system of cloud technology application for art entrepreneurship education was formed. The complex filling of cloud services with methodical support was substantiated, which will contribute to the mobility of educational technologies and the improvement of the quality of art entrepreneurship education. The possibilities of using the “flipped” technology of education in art entrepreneurship were determined and the methodological advantages of the “flipped” technology of education over traditional art-based business were substantiated.У статті досліджено питання активного впровадження хмарних технологій у художню освіту. Методична система проектування застосування хмарних технологій для мистецтва формувалася підприємницька освіта. Обґрунтовано комплексне наповнення хмарних сервісів методичною підтримкою, що сприятиме мобільності освітніх технологій та покращенню якості освіти художнього підприємництва. Визначено можливості використання «перевернутої» технології навчання художнього підприємництва та обґрунтовано методологічні переваги «перевернутої» технології освіти перед традиційним мистецьким бізнесом.В статье исследуется проблема активного внедрения облачных технологий в художественном образовании. Методическое проектирование системы применения облачных технологий для искусства предпринимательское образование было сформировано. Обосновано комплексное наполнение облачных сервисов методической поддержкой, что будет способствовать мобильности образовательных технологий и повышению качества обучения художественному предпринимательству. Определены возможности использования «перевернутой» технологии обучения в художественном предпринимательстве и Обоснованы методологические преимущества «перевернутой» технологии обучения над традиционным художественным бизнесом

N-arylsulfonyl-2-aroylamino-1,4-quinone imines and their hydrogenated analogues: prediction of toxicity and prospects for use as diuretics

Sokolova K.V., Podpletnia O.A., Konovalova S.O., Avdieienko A.P., Komarovska-Porokhniavets O.Z., Lubenets V.I., Kovalenko S.I. Continuing our research on compounds that affect urination, we have become interested in N-arylsulfonyl-2-aroylamino-1,4-quinone imines, which combine a quinone matrix with tolylsulfonamide and benzamide fragments with versatile biological activity in their structure, which has a promising value in preventing development of pathological processes in kidneys. Therefore, the search for low-toxic compounds with polyvector activity as a promising approach to the design of drug-like molecules has become an urgent aspect in this regard. The aim of this work was to investigate N-arylsulfonyl-2-aroylamino-1,4-quinone imines and their hydrogenated analogues as promising diuretic agents with antiradical and antibacterial activity using in silico, in vitro and in vivo methodologies. The virtual laboratory of the ProTox-II site is used to predict the toxicity of molecules. The study of compounds affecting the excretory function of the rat kidneys was carried out on 120 white Wistar rats according to the method of E.B. Berkhin under conditions of water stress and spontaneous urination. The interaction of the synthesised compounds with 2,2-diphenyl-1-picrylhydrazyl (DPPH) was used to study their antiradical activity in vitro. The antibacterial activity of the compounds was studied on test cultures of the bacteria Escherichia coli, Staphylococcus aureus, Mycobacterium luteum and the fungi Candida tenuis, Aspergillus niger by the method of serial dilutions in a liquid nutrient medium. Based on the results of the calculation, it was predicted that N-arylsulfonyl-2-aroylamino-1,4-quinone imines (2) and their hydrogenated analogues (3) have hepato-(immuno-, cyto-) toxicity, carcinogenicity (mutagenicity) similar to natural quinones and diuretics (toxicity class IV). This class of compounds has been shown to have both stimulatory and inhibitory effects on diuresis under condi­tions of water stress and spontaneous urination. At the same time, N-(5-methyl-6-oxo-3-(tosylimino)cyclohexa-1,4-dien-1-yl)benzamide (2.3) was revealed to increase daily diuresis by 67.1% compared with the control, exceeding the effect of «Furosemide» (22.2%). It was found that quinone imines (2.1-2.5) inhibited the formation of the DPPH radical by 25.99-40.09%, while their hydrogenated analogues (3.1 and 3.2) – by 61.56% and 68.28%, respectively, and are more effective acceptors of radicals. The microbiological screening revealed a number of promising compounds that inhibited the growth of S. aureus (compound 2.5, MIC 62.5 μg/ml, MBC 125.0 μg/ml), M. luteum (3.1 and 3.2, MIC 31.2 μg/ml, MBC 62.5 μg/ml) and A. niger (2.1, 2.4 and 3.2, MIC 31.2 μg/ml, MPC 62.5 μg/ml). According to the results of biological studies, among N-arylsulfonyl-2-aroylamino-1,4-quinone imines and their hydrogenated analogues, compound 2.3 has been iden­tified, which competes with «Furosemide» in potency and has high antibacterial activity against S. aureus. Other compounds show moderate antiradical activity, high antibacterial activity against M. luteum (2.1, 3.1) and antifungal activity against A. niger (2.1, 2.4, 3.2). The obtained results support the further research for diuretics with polyvector activity within this class of compounds