Особенности реализации острой коронарной недостаточности (ОКН) при оценке полиморфизма гена ITGB3

ITGB3 polymorphism affects some particular features of acute coronary insufficiency (ACI) and initially determines different patients’ condition according to the genotype of comorbidity, characteristics of atherosclerotic process in the coronary arteries, speed of the development of ACI, patient’s response to stress, platelet-vascular hemostasis mechanism, tolerance to drug therapy.Полиморфизм гена ITGB3 оказывает влияние на особенности реализации острой коронарной недостаточности, определяя исходно различный статус пациентов в зависимости от генотипа по сопутствующим заболеваниям, по характеру течения атеросклеротического процесса в коронарных артериях, по скорости реализации острой коронарной недостаточности, реакцию пациентов на стресс, особенности тромбоцитарно-сосудистого механизма гемостаза, толерантность к лекарственной терапии

THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE

14 children with various clinical forms of steroid-resistant nephrotic syndrome have been examined to assess the efficacy of pharmacological blocking of RAAS using inhibitors of angiotensin-converting enzyme and Angiotensin II receptor blockers. While assessing the efficacy of the nephroprotective therapy, the following was found in all the children: a reliably meaningful 1,5 times reduction ((р = 0,013) in the daily proteinuria level in 3 to 6 months, and by the end of the study — a 2,5 times reduction (р = 0,001) and improvement in the renal filtration function metrics in 3 to 6 months (р = 0,001), in 1 year (р = 0,013) and by the end of the study (p = 0,002) in comparison with the metrics prior to the launch of the nephroprotective therapy. Key words: chronic renal disease, proteinuria, RAAS, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers. (Pediatric Pharmacology. – 2010; 7(2):105-109

Analysis of the state of coronary arteries in patients with acute coronary syndrome in dependence on the integrin β-3 gene polymorphism

Aim of this study was to analyze the state of coronary arteries in patients with acute coronary syndrome according to polymorphism of integrin β-3 (ITGB3) gene. All patients were divided into 2 groups: carries and non-carries of PLA2 allele. Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events

Analysis of the State of Coronary Arteries in Patients With Acute Coronary Syndrome in Dependence on the Integrin beta-3 Gene Polymorphism

Aim of this study was to analyze the state of coronary arteries in patients with acute coronary syndrome according to polymorphism of integrin beta-3 (ITGB3) gene. All patients were divided into 2 groups: carries and non-carries of PLA2 allele. Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events

EFFICACY AND SAFETY OF PROLONGED TREATMENT WITH CYCLOSPORINE IN CHILDREN WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS

The article analyzes results of successful prolonged treatment of children with focal segmental glomerulosclerosis (FSGS). Treatment with cyclosporine (median dose 4–5 mg/kg of body weight) combined with prednisolone (1–1.5 mg/kg/48 hours) was performed in 34 patients 1.5–16 years old with FSGS. Pulse-treatment with methylprednisolone (30 mg/kg every other day, 3–6 injections) was performed in 21 patients for the purpose of remission induction. In 6 month of treatment with cyclosporine, total clinical and laboratory remission of corticosteroid-resistant nephrotic syndrome (CRNS) was detected in 12 (35%) patients, partial one — in 9 (26%) patients, remaining CRNS — in 13 (38%) of children. In 12 months of treatment total remission of CRNS was detected in 18 (53%) children, partial one — in 7 (21%) children, unefficient treatment — in 7 (21%) patients. Dose of prednisolone was decreased to minimal supporting level in 68% of children, and in 32% of patients corticosteroids were canceled. Thus, treatment with cyclosporine was effective in most children with SRNS and FSGS. Prolonged administration of cyclosporine up to 2 years and longer can be performed if regular control of kidney function is provided and symptoms of nephrotoxic action of this drug is absent (according to results of repeated biopsy).Key words: children, focal segmental glomerulosclerosis, cyclosporine, methylprednisolone.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):155-159

EFFICACY OF THE IMMUNOSUPPRESSIVE THERAPY AGAINST THE NEPHROTIC SYNDROME AMONG CHILDREN

The researchers evaluated the efficacy of different immunosuppressive medications in case of steroid dependent and steroid resistant variants of the nephrtic syndrome among children: traditional alkylating agents (cyclophosphamide, chlorbutin), cyclosporine and mycophenolate mofetil. Cyclosporine proved to be most efficient in treatment against steroid dependent nephritic syndrome, as the researchers were more often able to cancel the steroids, while the recurrence of the nephritic syndrome developed less often. In the event of the steroid resistant nephritic syndrome, the full/partial remission was achieved among more than 80% patients also treated by cyclosporine. In case of the proliferating forms of the steroid resistant nephritic syndrome, the positive outcome was achieved among all the children under observation, if mycophenolate mofetil and steroids were further applied. Therapy by the conventional alkylating agents (cyclophosphamide, chlorbutin) proved to be less efficient both for the relief from the steroid dependence and persistent remission of the steroid resistant nephritic syndrome.Key words: nephritic syndrome, immunosuppressive therapy, alkylating agents, cyclosporine, mycophenolate mofetil, children