Serum Uric Acid Levels in Oral Cancer Patients Seen at Tertiary Institution in Nigeria

Introduction: Toxicity by oxygen radicals has been considered as an important cause of cancer. It is proposed that the antioxidant properties of uric acid may act to prevent formation of oxygen radicals and thereby protect against carcinogenesis. This study aims to assess the role of uricacid in the aetiology of oral cancer.Materials and Methods: Thirty one oral cancer patients and thirty normal patients had serum uric acid measured using spectophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS19). Statistical significance was determined at P < 0.05. Results: The mean serum uric acid level in oral cancer patientswas 5.18 mg/dl (SD±1.96) while the mean was 7.09 mg/dl (SD±1.84) for the control group and this difference was statistically significant (p=0.000, t= -3.914, C.I. = - 2.885 to - 0.933). The risk of oral cancer was 3.98 times more in patients who had low serum uric acid.Conclusion: This study showed that serum uric acid was lower in oral cancer patients compared with healthy volunteers and low serum uric acid was associated with increased risk of oral cancer development. However, further prospective cohort studies are suggested to better understand the role of serum uric acid in aetiology of oral cancer

Palatal rugae as a tool for human identification

Objective: This study was conducted to assess the accuracy of palatal rugae as a tool for human identification and to determine factors that may limit accuracy. This will serve as a potential basis for advising national health policy formulation on human identification as forensic rugoscopy is unexplored in sub.Saharan Africa.Materials and Methods: One hundred consenting participants were  recruited; impressions of the upper jaws were taken and cast with dental stone. All the teeth on the models were trimmed off to prevent  identification by tooth morphology and the models were coded. Five uncalibrated dentists independently pair.matched the models based on the pattern of the palatal rugae.Results: The overall accuracy for all 50 paired models ranged from 72 to 96%, while the percentage correct match for each of the 50 paired models range from 40-100%. All the examiners properly matched 60% of the models. Conclusion: Rugoscopy is a useful technique for human identification due to the unique rugae pattern in every individual. However, without the aid of ancillary aids, visual inspection alone can be challenging. Clinical relevance: This study provides useful information on an additional clinical technique relevant for human identification.Key words: Forensic, human, identification, palatal rugae, rugoscopy, Ibadan, Nigeri

Dental anxiety among patients visiting a University Dental Centre

Objective: Fearful individuals often avoid care despite extensive dental needs and anxious patients feel more pain and of longer duration than less anxious patients. This study was designed to determine the prevalence and factors associated with dental anxiety among patients visiting a University Dental Centre in Nigeria. Method: This cross-sectional study was conducted using an anonymous structured questionnaire randomly administered to patients attending the University College Hospital Dental Centre, Ibadan. The questionnaire requested for socio-demographic data, dental visit behaviour, history of traumatic dental treatment and level of apprehension when anticipating a visit to the dentist and physician. The level of dental anxiety was determined using the Modified Dental Anxiety Scale (MDAS). An MDAS score of 19 and above indicated high dental anxiety. Upon examination, DMFT of each patient was determined. Result: A total of 471 respondents of which 262 (55.6%) were females participated in the study. Only 7.43% of the participants had MDAS score ≥19. About 10% of the females had high dental anxiety compared with 4.94% recorded for the males (p=0.01). Dental anxiety was more common among the younger age group, irregular oral health care seekers and among those with history of traumatic dental treatment. The respondents were more relaxed when anticipating a visit to a physician. Only gender could be used to predict high dental anxiety. Female gender significantly displayed high dental anxiety (odd ratio=3.05 and p=0.04) . The mean DMFT score for the patients was 2.48±3.30. Conclusion: The prevalence of dental anxiety among the respondents in this study was 7.43% and only gender could be used to predict dental anxiety

Torus palatinus and torus Mandibularis in a Nigerian population

Objective: The objectives of this study was to determine the prevalence, size, clinical characteristics, and location of torus palatinus (TP) and torus mandibularis (TM) in relation to age, sex and social stratification in a Nigerian population. Methods: One thousand three hundred and ninety two subjects were examined for the presence of both tori at the Out patient clinic of the Department of Oral Medicine and Pathology, School of Dentistry University College Hospital Ibadan, Nigeria. Results: Out of the 1,392 subjects examined, 52 (3.7%) had either Torus Palatinus (TP), Torus Mandibularis (TM) or both. The prevalence of TP and TM in the subjects were 1.8% and 2.5%, respectively. TP was significantly more common in females than in males (1.2% versus 0.6%). TP were frequently found in medium and small sizes and majority were solitary type. The prevalence of TM was higher in females than in males (1.9% versus 0.6%). TM occurred most commonly in small size, bilateral multiple forms, and was often located at the canine to premolar area. Females have both tori occurring concurrently more than male (Ratio 2 to 1). Most subjects with tori fall into class II social stratification, 51.9% compare with 21.1% and 23.0% as seen in Classes I and III respectively, 4.0% of subjects were unclassified. Conclusions: The prevalence of both tori in this Nigerian population was comparable to the Black Americans and other African populations. Key words: Torus mandibularis; torus palatinus; prevalence; social stratificatio

The role of forensic dentist following mass disaster

This review article focuses on mass disaster situations that may arise from natural or manmade circumstances and the significant role of forensic dental personnel in human identification following such occurrences. The various forensic dental modalities of identification that include matching techniques, postmortem profiling, genetic fingerprinting, dental fossil assessment and dental biometrics with digital subtraction were considered. The varying extent of use of forensic dental techniques and the resulting positive impact on human identification were considered. The importance of preparation by way of special training for forensic dental personnel, mock disaster rehearsal, and use of modern day technology was stressed. The need for international standardization of identification through the use of Interpol Disaster Victim Identification (DVI) for ms was further emphasized. Recommendations for improved human identification in Nigerian situation include reform of the National Emergency Management Association (NEMA), incorporation of dental care in primary health care to facilitate proper ante mortem database of the populace and commencement of identification at site of disaster

Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

Objectives: Tobacco and alcohol are major risk factors of oral cancer, but nutritional deficiency may also contribute to development of oral cancer. This study compared serum antioxidant vitamin levels in oral cancer patients and controls in order to validate the role of vitamin deficiencies in the etiology of oral cancer. Materials and Methods: Serum vitamin A, C, and E levels of 33 oral cancer patients and 30 controls at University College Hospital, Ibadan, Nigeria, were determined using standard methods. The data obtained were analyzed using the Student t‑test, odds ratio, and logistic regression. Results: Mean vitamin A, C, and E levels were significantly lower in oral cancer patients (P=0.022, P=0.000, and P=0.013 respectively). Risk of oral cancer was 10.89, 11.35, and 5.6 times more in patients with low serum vitamins A, C, and E, respectively. However, on logistic regression analysis, only low serum vitamin E independently predicted occurrence of oral cancer. Conclusions: The lower serum vitamin A, C, and E levels in oral cancer patients could be either a cause or an effect of the oral cancer. Further studies using a larger sample size and cohort studies with long‑term follow‑up of subjects are desirable.Keywords: Antioxidant vitamins, Nigeria, oral cancer riskNigerian Journal of Clinical Practice •Jan-Mar 2012 • Vol 15 • Issue

Abdominal Pain in Adult Sickle Cell Disease Patients: A Nigerian Experience

Background: Abdominal pain is a relatively frequent occurrence in sickle cell disease. The aetiology of abdominal pain in sickle cell disease is often difficult to diagnose clinically. Despite the frequent occurrence, diagnostic dilemma, and the need for an accurate, early diagnosis, abdominal pain insickle cell disease has not been rigorously studied.Objective: We therefore sought to describe the different presentations and patterns of abdominal pain in persons with sickle cell disease.Methods: A prospective case series of 20 patients was done in which data was collected on demographic characteristics, hemoglobin electrophoresis patterns, a description of the abdominal pain including sites, severity, and type of pain, packed cell volume and the provisional and final diagnosis.Results: Haemoglobin S patients were 17 in number constituting eightyfive percent (85%) of our study population whilst the rest 3 were Hb S+C. Most patients (70%) had one site of abdominal pain. The pain was mainly colicky or tightening, moderate to severe in nature and, in some cases, associated with vomiting. We did not find any significant difference between the steady state PCV and the PCV during the acute abdominal pain episodes. The final diagnosis showed that only 38.8% of the patientshad vasoocclusive crises and the reliability index between the provisional diagnosis and the final diagnosis was 67%.Conclusion: Abdominal pain in sickle cell disease may present in different ways and it is important to recognize that the possible diagnoses are numerous. Not all cases are due to vasoocclusive crises. Early diagnosisand prompt treatment can be life saving.Keywords - Abdominal Pain, Sickle Cell Disease, Anaemi

Actinomycotic gingival fibromatosis: report of a case and literature review

No abstract Nigerian Quarterly Journal of Hospital Medicine Vol. 13(1-2): 14-1

Molecular genetics of head and neck squamous cell carcinoma: A review

No Abstract

Psychosomatic Halitosis: The Need for a Cross Speciality Consultation

No Abstract Available African Journal for the Psychological Study of Social Issues Vol.6(2) 2001: 53-5