Rationalization of mass consuming

Современное российское общество стало обществом потребления, а основным критерием деления на социальные слои выступает уровень потребления, главным образом материального.The modern Russian society has become a consumer society, and the main criterion for separating social groups is the level of consumer mainly material

THE CONTENT OF STEROID HORMONES IN PATIENTS WITH CHOLELITHIASIS, DEPENDING ON THE DISEASE

Here, in this work, the peculiarities of secretion of steroid hormones have been researched in patients with gallstone disease depending on the course of the disease. It is suggested, that the lack of use of cholesterol for steroidogenesis leads to its precipitation in the composition of gallstones, increased cortisol is a limiting factor in inflammatory processes in the gall bladder. The increasing of testosterone synthesis may be considered as an antagonistic component of glucocorticoid regulation of lipid and protein metabolism

The changes of the tubular epithelium phenotype in the contralateral kidney nephrons while developing unilateral ureteral obstruction: an experimental study

Introduction. The high prevalence of renal diseases caused by urinary tract obstruction led to the need for experimental research of compensatory and pathological processes with kidney injury. It is also of relevance to study key mechanisms providing a compensatory function of the contralateral kidney for early diagnosis, treatment, and prognosis of obstructive renal diseases.Purpose of the study. To examine epithelial nephron cells phenotype dynamics changes in contralateral kidney using unilateral ureteral obstruction experimental model.Materials and methods. Model of unilateral ureteral obstruction was established using adult rabbits. The studies were carried out on days 7, 14 and 21 of complete obstruction of the left ureter. Immunophenotyping was performed on contralateral kidney tissue samples using epithelial (cytokeratin 7, E-cadherin) and mesenchymal (vimentin, α-smooth muscle actin) markers.Results. The contralateral kidney under additional load can maintain the morphological and functional characteristics of the nephron for a long time. The first transmogrify signs in the nephron epithelium phenotype were detected by day 21 as the diffuse appearance of mesenchymal marker vimentin with unaltered visualization of epithelial phenotype markers.Conclusion. The results obtained allow us to assume that the compensatory reserve of the contralateral kidney is gradually decreasing when the duration of the obstruction increases. Thus, the likelihood of developing negative disorders increases

Внедрение элементов учебного исследования с использованием математического пакета Mathcad

The variant of implementation of elements of research activity in the process of mastering by the first-year students of the technical directions of training in the discipline "Informatics" is considered. The proposed example is based on the application of mathematical packages for analyzing and processing experimental data, obtained in the course of physical experiment.Рассматривается вариант внедрения элементов исследовательской деятельности в процесс освоения студентами первого курса технических направлений подготовки учебной дисциплины «Информатика». Предлагаемый пример основывается на применении математических пакетов для анализа и обработки экспериментальных данных, получаемых в ходе физического эксперимента

Nanоbiocomposite based on dihydroquercetin and arabinogalactan in the form of a gel for external use as a means for the treatment of chronic venous insufficiency in an experiment

Background. Due to the high prevalence of chronic venous insufficiency among the population, with a decrease in the quality of life of patients and their early disability, there is a need to develop modern effective and safe means for the prevention and treatment of this pathology. We have developed the optimal composition and technology of a gel for external use based on a nanobiocomposite of dihydroquercetin and arabinogalactan, which has a venoprotective effect. The article presents data on the results of a preclinical study of the safety and specific activity of the gel.The aim. To study the specific activity (decongestant, antitranssudative action) and safety of a gel for external use based on nanobiocomposite of dihydroquercetin and arabinogalactan used for the treatment of chronic venous insufficiency in the framework of preclinical studies.Materials and methods. The object of the study was a gel for external use based on dihydroquercetin and arabinogalactan nanobiocomposite. The study was conducted on 32 white male rats of the same age, for 15 days. The study of the pharmacological activity of a gel based on a nanobiocomposite of dihydroquercetin and arabinogalactan, was carried out on a model of acute venous stagnation in the tail of a rat (edema of non-inflammatory genesis), the dynamics of tail volume growth in the experimental and control group of animals was evaluated. The irritant effect of the gel on the skin of animals was also determined, the permeability of the capillaries of the skin was determined.Results. When studying the pharmacological activity of the gel on a model of acute venous stagnation in the tail, it was shown that a soft dosage form for external use developed on the basis of nanobiocomposite of dihydroquercetin and arabinogalactan has decongestant and antitranssudative activity. The presence of a locally irritating effect in the gel under study has not been established in the framework of the experiment.Conclusion. In the course of preclinical study of the gel of the nanobiocomposite dihydroquercetin and arabinogalactan on laboratory animals, its antitranssudative activity and safety have been proven

The implementation elements of the rating assessment system

The variant of implementation of elements rating system for students of correspondence courses.Рассматривается вариант внедрения рейтинговой системы оценивания для студентов заочной формы обучения

The role of color in the terminology of childhood deseases

In this article we review Latin medical terms of childhood deseases which have colors in their concept. We also suggest the classification which considers the presence of color in the titles of Russian Federationn and Latin terms.В статье рассмотрены латинские медицинские термины детских болезней, в основе которых присутствует концепт «цвет», а также предложена их классификация с учетом наличия цвета в названиях русских и латинских терминов

The peculiarity of poisoning with various alcohols

The article contains necessary information for doctors about the poisoning of rare alcohols with clinical symptoms and pathogeny as well as comparative characteristics of known alcohols, such as ethanol.В статье приводится необходимая информация для медицинских сотрудников об отравлении редкими спиртами, их особенностях в клинике и патогенезе, а также сравнительная характеристика с отравлениями известных спиртов, таких как этано

Clinical course SARS-CoV-2 and pregnancy

The article discusses the modern aspects of the clinical manifestations of the coronavirus disease COVID-19 in pregnant women at various stages.В статье рассмотрены современные аспекты клинических проявлений новой коронавирусной инфекции COVID-19 у беременных на различных сроках гестации

Dynamics of hematological blood parameters of experimental animals with unilateral urinary tract obstruction

The aim of the study – to investigate the dynamics of hematological blood parameters in case of OMI in the experiment.Цель исследования – изучение динамики гематологических показателей крови при ОНМ в эксперименте