Functional relationships between brain and cerebellar cortex during absence and clonic seizures

Item does not contain fulltextThe relationships between frontal, temporal, and occipital zones of cortex of both hemispheres and paleocerebellar cortex in Wistar and WAG/Rij rats were investigated with an application of multiple linear regression analyses. Taking into consideration the dependence of epileptiform manifestations on sleep-wakefulness cycle, passive wakefulness state was used for data collection. The process of transition from absence to clonic seizure activity, which was provoked through the administration of sodium benzilpenicillin salt in WAG/Rij rats, was characterized as follows: 1) a preservation of high levels of interaction between brain structures in alpha band; 2) a pronounced decrease of interaction in delta and high-frequency rhythm bands; 3) moderate reduction of interaction between brain structures in the theta range. The increase of the number of connections of cerebellar cortex was marked in the course of transition from absence to clonic seizure activity, which might be in favor for the involvement of the cerebellum in the control of excitability of the brain.14 p