Advancing the Development of the Magneto-Active Slosh Control (MaSC) System for Spacecraft and Launch Vehicles

The Magneto-Active Propellant Management Device (MAPMD) system is designed to address safety hazards in liquid-propellant spaceflight caused by sloshing. This innovative system of Magneto-Active Slosh Control surpasses traditional passive slosh baffles by reducing mass, improving surface wave suppression, and minimizing volumetric intrusion (Santhanam 2012). In prior fight experiments conducted in collaboration between Embry-Riddle Aeronautical University and Carthage College, remnant slosh suppression was observed, however the effective slosh damping did not meet our expectations due to inadequate control forces. We are redesigning the magnetic membrane with multiple layers of ultrahigh-permeability metallic glass film and are developing an optimized configuration of current-carrying coils to increase magnetic force and field performance. These advancements are expected to elevate the MAPMD system\u27s Technology Readiness Level (TRL) from 3 to 4 in order to pave the way for microgravity flight testing. The MAPMD system promises to enhance the safety and performance of liquid-propellant spaceflight by actively managing slosh dynamics

A potential function for MicroRNA-124 in normal and pathological bone conditions

Cells produce short single-stranded non-coding RNAs (ncRNAs) called microRNAs (miRNAs), which actively regulate gene expression at the posttranscriptional level. Several miRNAs have been observed to exert significant impacts on bone health and bone-related disorders. One of these, miR-124, is observed in bone microenvironments and is conserved across species. It affects bone cell growth and differentiation by activating different transcription factors and signaling pathways. In-depth functional analyses of miR-124 have revealed several physiological and pathological roles exerted through interactions with other ncRNAs. Deciphering these RNA-mediated signaling networks and pathways is essential for understanding the potential impacts of dysregulated miRNA functions on bone biology. In this review, we aim to provide a comprehensive analysis of miR-124's involvement in bone physiology and pathology. We highlight the importance of miR-124 in controlling transcription factors and signaling pathways that promote bone growth. This review reveals therapeutic implications for the treatment of bone-related diseases