Association between vitamin D hypovitaminosis and severe forms of COVID-19

Objective: Hypovitaminosis D may be associated with an increased susceptibility to infection, more severe COVID-19 forms, and a higher risk of death. The objective of this study was to investigate any possible connections between vitamin D status [as measured by serum 25-hydroxyvitamin D (25(OH)D) levels] and COVID-19 severity. Patients and methods: In 2021, a cross-sectional study of consecutive adult COVID-19 patients was conducted. Anthropometric data, comorbidities, hospital setting, length of stay, respiratory support, outcome data, and vitamin D status were all evaluated. Results: The length of hospitalization among participants (n = 74; mean age 57.64 ± 17.83 years, 55.4% male) was 18.58 ± 10 days, the majority of the hospital setting was a medical ward (67.6%), and the respiratory support in the form of mechanical ventilation was represented by 12.2%. Hypertension (54.1%), obesity (64.9%), and overweight (64.9%) were the most common cardiometabolic risk factors. In the study group, 44.6% of participants had severe vitamin D deficiency (< 30 nmol/l), while 8.1% had vitamin D insufficiency (50 - 74.9 nmol/l). Furthermore, patients with severe COVID-19 (semi-intensive care unit, intensive care unit) had significantly lower serum 25(OH)D levels (32.9 vs. 20.5 nmol/l; p = 0.007). Participants with severe vitamin D deficiency were older and had more prevalent hypertension, requiring mechanical ventilation; 24.2% experienced a fatal outcome. Conclusions: Severe vitamin D deficiency may contribute significantly to the influence of other cardiometabolic risk factors in COVID-19

Response of the Earth’s Lower Ionosphere to Solar Flares and Lightning-Induced Electron Precipitation Events by Analysis of VLF Signals: Similarities and Differences

The lower ionosphere influences the propagation of electromagnetic (EM) waves, satellite and also terrestrial (anthropic) signals at the time of intense perturbations and disturbances. Therefore, data and modelling of the perturbed lower ionosphere are crucial in various technological areas. An analysis of the lower ionospheric response induced by sudden events during daytime-solar flares and during night-time-lightning-induced electron precipitation was carried out. A case study of the solar flare event recorded on 7 September 2017 and lightning-induced electron precipitation event recorded on 16 November 2004 were used in this work. Sudden events induced changes in the ionosphere and, consequently, the electron density height profile. All data are recorded by Belgrade (BEL) radio station system and the model computation is used to obtain the ionospheric parameters induced by these sudden events. According to perturbed conditions, variation of estimated parameters, sharpness and reflection height differ for analysed cases. Data and results are useful for Earth observation, telecommunication and other applications in modern society

Response of the Earth&rsquo;s Lower Ionosphere to Solar Flares and Lightning-Induced Electron Precipitation Events by Analysis of VLF Signals: Similarities and Differences

The lower ionosphere influences the propagation of electromagnetic (EM) waves, satellite and also terrestrial (anthropic) signals at the time of intense perturbations and disturbances. Therefore, data and modelling of the perturbed lower ionosphere are crucial in various technological areas. An analysis of the lower ionospheric response induced by sudden events during daytime-solar flares and during night-time-lightning-induced electron precipitation was carried out. A case study of the solar flare event recorded on 7 September 2017 and lightning-induced electron precipitation event recorded on 16 November 2004 were used in this work. Sudden events induced changes in the ionosphere and, consequently, the electron density height profile. All data are recorded by Belgrade (BEL) radio station system and the model computation is used to obtain the ionospheric parameters induced by these sudden events. According to perturbed conditions, variation of estimated parameters, sharpness and reflection height differ for analysed cases. Data and results are useful for Earth observation, telecommunication and other applications in modern society

Orthogonal Control of Neuronal Circuits and Behavior Using Photopharmacology

Over the last decades, photopharmacology has gone far beyond its proof-of-concept stage to become a bona fide approach to study neural systems in vivo. Indeed, photopharmacological control has expanded over a wide range of endogenous targets, such as receptors, ion channels, transporters, kinases, lipids, and DNA transcription processes. In this review, we provide an overview of the recent progresses in the in vivo photopharmacological control of neuronal circuits and behavior. In particular, the use of small aquatic animals for the in vivo screening of photopharmacological compounds, the recent advances in optical modulation of complex behaviors in mice, and the development of adjacent techniques for light and drug delivery in vivo are described

Data for Photodissociation of Some Small Molecular Ions Relevant for Astrochemistry and Laboratory Investigation

The calculated photodissociation data of some small molecular ions have been reported. The cross-sections and spectral rate coefficients data have been studied using a quantum mechanical method. The plasma parameters, i.e., conditions, cover temperatures from 1000 to 20,000 K and wavelengths in the EUV and UV region. The influence of temperature and wavelength on the spectral coefficients data of all of the investigated species have been discussed. Data could also be useful for plasma diagnostics in laboratory, astrophysics, and industrial plasmas for their modelling

Augmented Reality and Intraoperative Navigation in Sinonasal Malignancies: A Preclinical Study

Objective: To report the first use of a novel projected augmented reality (AR) system in open sinonasal tumor resections in preclinical models and to compare the AR approach with an advanced intraoperative navigation (IN) system. Methods: Four tumor models were created. Five head and neck surgeons participated in the study performing virtual osteotomies. Unguided, AR, IN, and AR + IN simulations were performed. Statistical comparisons between approaches were obtained. Intratumoral cut rate was the main outcome. The groups were also compared in terms of percentage of intratumoral, close, adequate, and excessive distances from the tumor. Information on a wearable gaze tracker headset and NASA Task Load Index questionnaire results were analyzed as well. Results: A total of 335 cuts were simulated. Intratumoral cuts were observed in 20.7%, 9.4%, 1.2,% and 0% of the unguided, AR, IN, and AR + IN simulations, respectively (p < 0.0001). The AR was superior than the unguided approach in univariate and multivariate models. The percentage of time looking at the screen during the procedures was 55.5% for the unguided approaches and 0%, 78.5%, and 61.8% in AR, IN, and AR + IN, respectively (p < 0.001). The combined approach significantly reduced the screen time compared with the IN procedure alone. Conclusion: We reported the use of a novel AR system for oncological resections in open sinonasal approaches, with improved margin delineation compared with unguided techniques. AR improved the gaze-toggling drawback of IN. Further refinements of the AR system are needed before translating our experience to clinical practice

Projected cutting guides using an augmented reality system to improve surgical margins in maxillectomies: A preclinical study

Background: Positive margins have been reported up to 80% in advanced maxillary cancers. Intraoperative navigation (IN) aims to improve margins, but provides a two-dimensional view of a registered instrument without anticipating any cutting directions, and the information is displayed in monitors outside surgical field. Augmented Reality (AR) can delineate margins while addressing the gaze-toggling drawback of IN. In a preclinical setting, we implemented preoperative-planned osteotomies needed for maxillectomies and projected this information on the surgical field using AR. We aimed to improve negative margin rates while retaining the benefits of AR. Methods: Five maxillary tumor models were built. Five fellowship-trained surgeons completed virtual unguided and AR-guided maxillectomies. Comparisons in terms of intratumoral cuts, close, adequate, and excessive distances from the tumor were performed. Differences between “ideal” cutting-plan and the AR-guided virtual osteotomies was obtained. Workload questionnaires to evaluate the technology were completed. Results: 115 virtual osteotomies were analyzed. Intra-tumoral and “close” margins were lower for the AR-assisted osteotomies (0.0% vs 1.9% p < 0.0001 and 0.8% vs 7.9% p < 0.0001). Proportion of “adequate” margins were higher in the AR simulations (25.3% vs 18.6%, p = 0.018). The AR osteotomies had high similarity with the pre-planned with interclass correlation index close to 1 in “adequate” margins 0.893 (95% CI: 0.804–0.949). Workload scores were better for AR-guided simulations for the domains of mental demand, performance, effort and frustration. Conclusion: The projector-based AR method improved margin delineation, and preoperative planning was accurately translated to the simulations. Clinical translation will aim to consolidate our preclinical findings to improve outcomes

Out‐of‐pocket costs associated with head and neck cancer treatment

Abstract Background Out‐of‐pocket costs (OOPC) associated with treatment have significant implications on quality of life and survival in cancer patients. Head and neck cancer patients face unique treatment‐related challenges, but to date OOPC have been understudied in this population. Aims This study aims to identify and measure OOPC for patients with head and neck cancer (HNC) in Ontario. Methods HNC patients between 2015 and 2018 at Princess Margaret Cancer Centre in Toronto were recruited. Participants completed OOPC questionnaires and lost income questions during radiation, post‐surgery, and 3, 6, 12, and 24 months after completion of treatment. Associations between OOPC and treatment modality and disease site were tested with multivariable hurdle regression. Results A total of 1545 questionnaires were completed by 657 patients. Median estimated OOPC for the total duration of treatment for participants undergoing chemoradiation was $1452 [$0–14 616], for surgery with adjuvant radiation or chemoradiation (C/RT) was $1626, for radiation therapy alone was$635, and for surgery alone was $360. The major expenses for participants at the mid‐treatment time‐point was travel (mean$424, standard error of the mean [SEM] $34) and meals, parking, and accommodations (mean$617, SEM $67). In multivariable analysis, chemoradiation, surgery with C/RT, and radiation were associated with significantly higher OOPC than surgery alone during treatment (791% higher, p < .001; 539% higher, p < .001; 370% higher, p < .001 respectively) among patients with non‐zero OOPC. Participants with non‐zero OOPC in the laryngeal cancer group paid 49% lower OOPC than those with oropharyngeal cancers in adjusted analysis (p = .025). Conclusions Patients undergoing treatment for HNC pay significant OOPC. These costs are highest during treatment and gradually decrease over time. OOPC vary by patient demographics, clinical factors, and, in particular, treatment modality