2 research outputs found
Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents
This letter describes the preparation of quinoline derivatives and their cytotoxic potentials toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2-quinolinecarbaldehyde (3) showed the best in vitro cytotoxicity against the human cancer cell lines, including MDA231, T-47D, Hs578t, SaoS2, K562, SKHep1 (with a MTS50 range of 12.5–25 μg/mL) and Hep3B (with a MTS50 range of 6.25±0.034 μg/mL). The in vivo antitumor activity of compound 3 on subcutenaous Hep3B hepatocellular carcinoma xenograft in athymic nude mice was then studied. The results showed that the dose of 10 mg/kg/day of compound 3 with intraperitoneal injection for 9 days totally abolished the growth of the xenograft tumor of Hep3B with no histological damage on vital organs as compared with the control. The experimental results suggested that compound 3 has a good potential as an antitumor agent
Synthesis of 8‑Hydroxyquinoline Derivatives as Novel Antitumor Agents
This letter describes the preparation of quinoline derivatives
and their cytotoxic potentials toward human carcinoma cell lines.
Among the selected compounds, 8-hydroxy-2-quinolinecarbaldehyde (<b>3</b>) showed the best <i>in vitro</i> cytotoxicity
against the human cancer cell lines, including MDA231, T-47D, Hs578t,
SaoS2, K562, SKHep1 (with a MTS<sub>50</sub> range of 12.5–25
μg/mL) and Hep3B (with a MTS<sub>50</sub> range of 6.25±0.034
μg/mL). The <i>in vivo</i> antitumor activity of compound <b>3</b> on subcutenaous Hep3B hepatocellular carcinoma xenograft
in athymic nude mice was then studied. The results showed that the
dose of 10 mg/kg/day of compound <b>3</b> with intraperitoneal
injection for 9 days totally abolished the growth of the xenograft
tumor of Hep3B with no histological damage on vital organs as compared
with the control. The experimental results suggested that compound <b>3</b> has a good potential as an antitumor agent