A Study on “Subject Contents Organization (SCO)” for Teacher Training Program in the Faculty of Education, Okayama University : Practice and Assessment of SCO in Elementary School and Junior High School Teacher Training Curriculum

　岡山大学教育学部・教師教育開発センターは，平成23 ～ 27年度「教員の資質向上に寄与する『大学と学校・教育委員会の協働』の実現−学校教育改善との連動で教員養成教育を進化させる−(先進的教員養成プロジェクト)」に取り組んだ。その中の教科構成学開発事業では，本学部で独自に構築・実施しているコア・カリキュラムの中での教科内容構成のあり方について，２つのプロセスから研究を行った。本稿では，平成26年度に学部教育全体で取り組んだ「教科内容構成要素に関するシラバス記述」と，部会員が平成26・27年度に授業を実践した小・中学校の教職および教科に関する科目（数学・理科・家庭科・国語科）の受講生に対して実施した「教科内容構成力」に関するアンケート調査の分析から，本学部の教科内容構成研究の特徴と課題について検討した

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy.Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure–activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy

A Study on “Subject Contents Organization (SCO)” for Teacher Training Program in the Faculty of Education, Okayama University : Practice and Assessment of SCO in Elementary School and Junior High School Teacher Training Curriculum

　岡山大学教育学部・教師教育開発センターは，平成23 ～ 27年度「教員の資質向上に寄与する『大学と学校・教育委員会の協働』の実現−学校教育改善との連動で教員養成教育を進化させる−(先進的教員養成プロジェクト)」に取り組んだ。その中の教科構成学開発事業では，本学部で独自に構築・実施しているコア・カリキュラムの中での教科内容構成のあり方について，２つのプロセスから研究を行った。本稿では，平成26年度に学部教育全体で取り組んだ「教科内容構成要素に関するシラバス記述」と，部会員が平成26・27年度に授業を実践した小・中学校の教職および教科に関する科目（数学・理科・家庭科・国語科）の受講生に対して実施した「教科内容構成力」に関するアンケート調査の分析から，本学部の教科内容構成研究の特徴と課題について検討した

DIP2A Functions as a FSTL1 Receptor*

FSTL1 is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. We identified DIP2A as a novel FSTL1-binding partner from the membrane fraction of endothelial cells. Co-immunoprecipitation assays revealed a direct physical interaction between FSTL1 and DIP2A. DIP2A was present on the cell surface of endothelial cells, and knockdown of DIP2A by small interfering RNA reduced the binding of FSTL1 to cells. In cultured endothelial cells, knockdown of DIP2A by small interfering RNA diminished FSTL1-stimulated survival, migration, and differentiation into network structures and inhibited FSTL1-induced Akt phosphorylation. In cultured cardiac myocytes, ablation of DIP2A reduced the protective actions of FSTL1 on hypoxia/reoxygenation-induced apoptosis and suppressed FSTL1-induced Akt phosphorylation. These data indicate that DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1