Organocatalytic C–H/C–H′ Cross-Biaryl Coupling: C‑Selective Arylation of Sulfonanilides with Aromatic Hydrocarbons

The hypervalent iodine-mediated C–C selective coupling of <i>N</i>-methanesulfonyl anilides with aromatic hydrocarbons has been developed. The first organocatalytic oxidative cross-biaryl-coupling was achieved by the catalyst control in defining specific 2,2′-diiodobiphenyls for the direct C–C bond formations

Comparison of SUVmax levels after combination of tumor size and geminin levels.

<p>SUVmax levels for groups with tumor size ≤2cm and geminin-low (G-L), ≤2cm and geminin-high (G-H), >2cm and geminin-low (G-L) and >2cm and geminin-high (G-H). Boxes represent median values and upper and lower quartiles.</p

Univariable and multivariable analyses of clinical and immunohistochemical factors for SUVmax levels.

<p>Univariable and multivariable analyses of clinical and immunohistochemical factors for SUVmax levels.</p

Receiver operating characteristics curves of pS6, pMAPK, TP53, geminin and Ki67 for SUVmax.

<p>The cutoff values were determined as 10% for pS6 (A), 20% for pMAPK (B), 20% for TP53 (C), 4% for geminin (D) and 21.5% for Ki67 (E).</p

SUVmax levels according to tumor size and geminin expression levels.

<p>SUVmax levels according to tumor size and geminin expression levels.</p

Representative positive immunostaining for pS6 (A), pMAPK (B), TP53 (C) and geminin (D).

<p>Staining of cytoplasm (pS6), cytoplasm and nuclei (pMAPK) and nuclei (TP53 and geminin) was evaluated.</p

Correlations between SUVmax levels and pS6 (A), pMAPK (B), TP53 (C), geminin (D) or Ki67 (E) labeling indices and tumor size (F).

<p>Correlations between SUVmax levels and pS6 (A), pMAPK (B), TP53 (C), geminin (D) or Ki67 (E) labeling indices and tumor size (F).</p