Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study

Electrophysiological studies of the human heart face the fundamental challenge that experimental data can be acquired only from patients with underlying heart disease. Regarding human atria, there exist sizable gaps in the understanding of the functional role of cellular Ca2+ dynamics, which differ crucially from that of ventricular cells, in the modulation of excitation-contraction coupling. Accordingly, the objective of this study was to develop a mathematical model of the human atrial myocyte that, in addition to the sarcolemmal (SL) ion currents, accounts for the heterogeneity of intracellular Ca2+ dynamics emerging from a structurally detailed sarcoplasmic reticulum (SR). Based on the simulation results, our model convincingly reproduces the principal characteristics of Ca2+ dynamics: 1) the biphasic increment during the upstroke of the Ca2+ transient resulting from the delay between the peripheral and central SR Ca2+ release, and 2) the relative contribution of SL Ca2+ current and SR Ca2+ release to the Ca2+ transient. In line with experimental findings, the model also replicates the strong impact of intracellular Ca2+ dynamics on the shape of the action potential. The simulation results suggest that the peripheral SR Ca2+ release sites define the interface between Ca2+ and AP, whereas the central release sites are important for the fire-diffuse-fire propagation of Ca2+ diffusion. Furthermore, our analysis predicts that the modulation of the action potential duration due to increasing heart rate is largely mediated by changes in the intracellular Na+ concentration. Finally, the results indicate that the SR Ca2+ release is a strong modulator of AP duration and, consequently, myocyte refractoriness/excitability. We conclude that the developed model is robust and reproduces many fundamental aspects of the tight coupling between SL ion currents and intracellular Ca2+ signaling. Thus, the model provides a useful framework for future studies of excitation-contraction coupling in human atrial myocytes

On the feasibility of out-of-band spatial channel information for millimeter-wave beam search

Abstract Prolonged beam alignment is the main source of overhead in mobile wireless communications at millimeter-wave (mm-wave) frequencies due to narrow beams following the requirement of high antenna gains. Out-of-band spatial information may be used in initial beam search when lower frequency band radios are operating in conjunction with mm-wave radios. The feasibility of using low-band channel information for coarse estimation of high-band beam directions strongly depends on the spatial congruence between the two frequency bands. In this work, we try to answer two related questions. First, how similar is the power angular spectrum (PAS) of propagation channels between two widely separated frequency bands? Then, what is the impact of practical antenna configurations on spatial channel similarity? We propose a beam directions based metric to assess the power loss and number of false directions if out-of-band spatial information is used instead of in-band information. This metric is more practical and useful than comparing the PASs directly. Point cloud ray tracing and propagation measurement results across multiple frequency bands and environments are used to show that the degree of spatial similarity of beamformed channels is related to antenna beam widths, frequency gap, and radio link conditions

Out-of-band information aided mmWave/THz beam search:a spatial channel similarity perspective

Abstract The transition to higher frequency bands, e.g., millimeter-wave (mmWave) and terahertz (THz), will be capitalized on the long term for future wireless communications. One of challenges relates to rapid establishment of mmWave/THz links with low beam training overhead due to highly directional transmission. A promising solution is to take advantage of the coexistence of sub-6 GHz, mmWave, and THz wireless networks and to use out-of-band spatial information for enabling fast beam search. The success depends on the spatial similarity of radio channels across different frequency bands. In this article we promote a feasibility study of low-frequency spatial channel information assisted high-frequency beam search from a radio channel point of view. We develop multi-band channel similarity measure of desired beam directions extracted from radio channels, which are obtained via filtering propagation paths by different beampatterns at different frequencies. Measurementand ray-tracing-based evaluations across multiple frequencies and environments are performed, which prove the usability of out-of-band information aided beam search strategy in line-ofsight (LOS) dominated scenario and even in non-LOS scenario. Finally, we discuss the challenges associated with exploiting spatial channel similarity