Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer: two case reports

INTRODUCTION: A hamartomatous polyp without associated mucocutaneous pigmentation or a family history of Peutz-Jeghers Syndrome is diagnosed as a solitary Peutz-Jeghers type hamartomatous polyp. As compared with Peutz-Jeghers Syndrome, Peutz-Jeghers type hamartomatous polyps are diagnosed with a lower risk of cancer and are regarded as a different disorder. CASE PRESENTATION: In case one, we describe an 84-year-old Japanese man with a 14 mm duodenal polyp. Endoscopic mucosal resection was performed and histological examination showed findings suggestive of a hamartomatous polyp with a focus of well-differentiated adenocarcinoma. In case two, we describe a 76-year-old Japanese man who had been treated for prostate, rectal and lung cancer. Upper gastrointestinal endoscopy revealed a duodenal polyp measuring 15 mm in diameter. Endoscopic mucosal resection was performed, and histological examination showed findings suggestive of a hamartomatous polyp. Liver and thyroid cancers were found after the endoscopic treatment. CONCLUSION: Although duodenal solitary hamartomatous polyps are associated with a lower risk of cancer, four patients, including our cases, have been diagnosed with cancerous polyps. Patients with duodenal solitary hamartomatous polyps should be treated by endoscopic or surgical resection and need whole-body screening

Nursing Practicum Based on the Philosophy of Seirei Held at Seirei-related Welfare Facilities in the Spring Semester of the First Year at Seirei Christopher University

P(論文)聖隷看護基盤実習は、入学直後の1 年次生春セメスターに聖隷ゆかりの福祉施設などに赴き、看護を学ぶ上で基盤となる対人援助職としてのあり方を、建学の精神や聖隷の理念を礎に、学生自身の体験を振り返りながら学ぶ実習である。聖隷ゆかりの施設における臨地実習では、創設期からの歴史的な変遷や活動を知り、キリスト教精神を基盤とした建学の精神や聖隷の理念について考え、施設での出会いや語りから、対人援助職としてのあり方を、聖隷の理念と関連させて意味づけていく。 　本報告では、聖隷クリストファー大学看護基礎教育における2022 年度の聖隷看護基盤実習の創設について、①聖隷看護基盤実習の構築（看護学部学位授与方針、カリキュラムポリシー）、②単位、セメスター履修者数、③科目概要、④実習目標、⑤実習展開、⑥学内委員会・授業との連携、⑦実習記録の構成をふまえ報告する。紀要委員会企画Special Articlesdepartmental bulletin pape

Measurement of Oral Moisture on Oral Dryness Patients

Many elderly patients have oral dryness; thus, it is necessary to evaluate the oral moisture in a clinical setting. The aim of this study was to clarify the importance of controlling the measuring pressure of the oral moisture-checking device. The influence of the measuring pressure of the oral moisture-checking device was examined using agar under 10 measuring pressure conditions (Kruskal–Wallis test). Fifty-five oral dryness patients were examined the lingual moisture using the device with and without a tongue depressor. The tongue depressor was placed underneath the tongue to support it during the measurement. The mean value and the coefficient of variation of five measurements was evaluated (paired t-test or Wilcoxon signed-ranks test). The agar moisture values changed according to the measuring pressure (p < 0.05). The lingual moisture value with the tongue depressor was higher than that without the tongue depressor (p < 0.05). The coefficient of variation with the tongue depressor was smaller than that without the tongue depressor (p < 0.01). The results of this study indicated that the measuring pressure of oral moisture-checking device influenced the measurement value, and it is necessary to support the tongue for the measurement of lingual mucosal moisture in a uniform manner

オンダン シツジュン キコウ コウショク ヒリツ チイキ オ タイショウ ト シタ ドジョウ スイリ トクセイ ノ スイテイ ト チシツ コウガクテキ オウヨウ ニ カンスル チショクブツガクテキ リモートセンシング ケンキュウ

本研究では、低コストで社会環境上の制約が少なく、広域を均一な精度で、かつ短期間で調査可能なリモートセンシング技術に着目し、地質構造の分布とその水利特性の把握に関するリモートセンシング技術の適用可能性について検討した

Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

Oral dryness as a side effect of certain drugs is increasing. The aim of this study was to examine the change of the protein ingredient in saliva of oral dryness patients caused by calcium blocker. Six patients taking calcium blocker and six healthy elderly were enrolled. Unstimulated salivary flow rate, protein concentration, and flow rate of protein were measured and compared between the patients taking calcium blocker and healthy elderly. iTRAQ (Isobaric Tag for Relative and Absolute Quantitation) proteomic analysis was performed to extract the salivary protein changed in patient taking calcium blocker, and the intensities of Western blotting products were quantified (unpaired t-test). Unstimulated salivary flow rate was significantly lower on patients taking calcium blocker (p < 0.01). Protein concentration tended to be higher and the flow rate of protein tended to be lower on patients. As the result of iTRAQ proteomic analysis, calmodulin-like protein 3, glutathione S-transferase P, and keratin type I cytoskeletal 13 increased characteristically in patient taking calcium blocker, and the expression in calmodulin-like protein 3 was significantly larger (p < 0.01). The results of this study indicated that calmodulin-like protein 3 increased in patients taking calcium blocker and could be a salivary biomarker for oral dryness caused by calcium blocker