Efficacy of Early Inpatient Rehabilitation of Post-COVID-19 Survivors: Single-Center Retrospective Analysis

OBJECTIVE: The aim of this study was to understand the demographic, clinical characteristics, and effectiveness of early inpatient rehabilitation of post-COVID survivors. DESIGN: A single-center retrospective chart review analysis of 100 patients admitted to a newly created acute COVID rehabilitation unit (CORE+) from April to December 2020 was conducted. RESULTS: The demographic and clinical characteristics and complications of 100 post-COVID patients were reviewed. Functional outcomes of GG Self-care and Mobility Activities Items (Section GG0130 and GG0170) of the Centers for Medicare & Medicaid Services of the Inpatient Rehabilitation Facility Patient Assessment Instrument (Version 3.0) at admission and discharge, prevalence of oxygen requirement, the need for cognitive and neuropsychology support by discharge, and dispositions after completion of inpatient rehabilitation facility stay were analyzed. The functional outcomes of 59 primary pulmonary manifestations of COVID patients were further analyzed based on the presence of intensive care unit stay before transfer to the COVID rehabilitation unit. Most patients demonstrated significant functional gains after completion of inpatient rehabilitation facility stay; however, a considerable number of patients continued to require cognitive support by discharge. CONCLUSION: The data suggested the benefit of early rehabilitation for hospitalized post-COVID patients. Services need to be geared to include patients\u27 cognitive deficits

Information Mechanisms in Vanadium Selenite Oxalates

Ten organically templated vanadium selenite oxalates were synthesized under mild hydrothermal conditions and were characterized by single crystal X-ray diffraction. Nine of\ud these compounds (1-8b) exhibited one of two distinct 2-dimensional layer topologies with\ud identical [(VO)2(C2O4)(SeO3)2]n 2n- compositions. The compounds containing 1,4-\ud dimethylpiperizine (1), 2,5-dimethylpiperizine (2), N,N′-dimethylethylenediamine (3), N,N,N'-\ud trimethylethylenediamine (4), and N,N-Dimethyl-N′-ethylethylenediamine (5) exhibit [(VO)2(C2O4)(SeO3)2]n 2n- layers in which the dimers adopt a rectangular tessellation. In contrast, the compounds that contain 1-methylpiperizine (6), racemic 2-methylpiperizine (7), (R)-2-\ud methylpiperizine (8a), and (S)-2-methylpiperizine (8b) contain [(VO)2(C2O4)(SeO3)2]n 2n- layers\ud with herringbone-type patterns of dimers. The size of the amine-footprint dictates the layer type. In order to minimize the inter-layer void space, the smaller amines pack more closely together, forcing the formation of the denser herringbone-type layers so that charge neutrality is maintained. The larger amines are able to accommodate the less dense rectangular layers. An additional compound with a 1-dimensional chained structure was synthesized with\ud triethylenetetramine (9). Compound 9 is the only known vanadium selenite oxalate to exhibit a\ud 1-dimensional structure

Formation Principles for Templated Vanadium Selenite Oxalates

A set of formation principles governing organically templated vanadium selenite oxalates are described in the context of nine new compounds. The compositions of the reaction mixture dictate the form of the secondary building units from which [(VO)₂­(C₂O₄)­(SeO₃)₂]_<i>n</i>^2<i>n</i>– layers are constructed. The strength of hydrogen-bonding interactions is maximized in these compounds, directly affecting the orientations of the organic ammonium cations and enabling amine packing efficiency to affect layer tessellation. The orientations of selenite stereoactive lone pairs are driven by the minimization of internal void space. Compound symmetry can be directed to chiral space groups through the use of chiral components, with the use of either (<i>R</i>)-2-methylpiperazine or (<i>S</i>)-2-methylpiperazine, resulting in noncentrosymmetric, polar, chiral structures that crystallize in the space group <i>P</i>2₁ (No. 4)

Formation Principles for Templated Vanadium Selenite Oxalates

A set of formation principles governing organically templated vanadium selenite oxalates are described in the context of nine new compounds. The compositions of the reaction mixture dictate the form of the secondary building units from which [(VO)₂­(C₂O₄)­(SeO₃)₂]_<i>n</i>^2<i>n</i>– layers are constructed. The strength of hydrogen-bonding interactions is maximized in these compounds, directly affecting the orientations of the organic ammonium cations and enabling amine packing efficiency to affect layer tessellation. The orientations of selenite stereoactive lone pairs are driven by the minimization of internal void space. Compound symmetry can be directed to chiral space groups through the use of chiral components, with the use of either (<i>R</i>)-2-methylpiperazine or (<i>S</i>)-2-methylpiperazine, resulting in noncentrosymmetric, polar, chiral structures that crystallize in the space group <i>P</i>2₁ (No. 4)