26 research outputs found
Quality of Life Following Repair of Large Hiatal Hernia is Improved but not Influenced by Use of Mesh: Results From a Randomized Controlled Trial
Author version made available following 12 month embargo from date of publication (5 Feb 2015) in accordance with Publisher copyright policy.Introduction
Laparoscopic surgery is the treatment of choice for repair of large hiatus hernia, but can be
followed by recurrence. Repair with prosthetic mesh has been recommended to prevent
recurrence, although complications following mesh repair have generated disagreement about
whether or not mesh should be used. The early objective and clinical results of a randomized
trial of repair with mesh vs. sutures have been reported, and revealed few differences. In the
current study we evaluated quality of life outcomes within this trial at follow-up to 2 years.
Methods
In a multicenter prospective double-blind randomized trial three methods for repair of large
hiatus hernia were compared: sutures vs. repair with absorbable mesh (Surgisis) vs. nonabsorbable
(Timesh). Quality of life assessment using the Short-Form 36 (SF-36)
questionnaire was undertaken at 3, 6, 12 and 24 months after surgery. SF-36 outcomes (8
individual scales and 2 composite scales) were determined for each group, and compared
between groups, and across different follow-up points.
Results
126 patients were enrolled - 43 sutures, 41 absorbable mesh and 42 non-absorbable mesh. 115
(91.3%) completed a preoperative questionnaire, and 113 (89.7%) completed the postoperative
questionnaire at 3 months, 116 (92.1%) at 6 months, 114 (90.5%) at 12 months, and
91 (72.2%) at 24 months. The SF-36 Physical and Mental Component scores (PCS & MCS)
improved significantly following surgery, and this improvement was sustained across 24
months follow-up (p<0.001 for PCS and MCS at each follow-up point). There were no
significant differences between the groups for the component scores or the eight SF-36
subscale scores at each follow-up time. 29 individuals had a recurrence at 6 months follow-up,
of which 9 were symptomatic. The PCS were higher in patients with recurrence vs. without
(p<0.01), and in patients with a symptomatic recurrence vs. asymptomatic recurrence vs. no
recurrence (p=0.001).
Conclusion
SF-36 measured quality of life improved significantly after repair of large hiatal hernia at up
to 2 years follow-up, and there were no differences in outcome for the different repair techniques. The use of mesh vs. no mesh in repair of large hiatal hernia did not influence
quality of life
Structural Basis of Response Regulator Dephosphorylation by Rap Phosphatases
Crystallographic, biochemical, and genetic studies reveal the mechanism of Rap protein phosphatase activity within the phosphorelay pathway leading to sporulation in Bacillus species
Evaluation of atrial fibrillation induced during anesthesia with fentanyl and pentobarbital in German Shepherd Dogs with inherited arrhythmias
abstract: Objective: Animals: Procedures: Results: Conclusions and Clinical Relevance: To determine the type of atrial fibrillation induced by use of 2 pacing protocols during fentanyl and pentobarbital anesthesia before and after administration of atropine and to determine the organization of electrical activity in the left and right atria during atrial fibrillation in German Shepherd Dogs.7 German Shepherd Dogs.Extrastimulus and pacedown protocols were performed before and after atropine administration. Monophasic action potential spectral entropy and mean dominant frequency were calculated during atrial fibrillation.Atrial fibrillation occurred spontaneously in 6 of 7 dogs. All 7 dogs had atrial fibrillation induced. Sustained atrial fibrillation occurred in 13 of 25 (52%) episodes induced by the extrastimulus protocol and in 2 of 12 episodes of atrial fibrillation induced by pacedown. After atropine administration, sustained atrial fibrillation did not occur, and the duration of the nonsustained atrial fibrillation (6 episodes in 2 dogs of 1 to 26 seconds) was significantly shorter than before atropine administration (25 episodes in 7 dogs of 1 to 474 seconds). The left atrium (3.67 +/- 0.08) had lower spectral entropy than the right atrium (3.81 +/- 0.03), indicating more electrical organization in the left atrium. The mean dominant frequency was higher in the left atrium in 3 dogs.Atrial fibrillation developed spontaneously and was induced in German Shepherd Dogs under fentanyl and pentobarbital anesthesia. Electrical activity was more organized in the left atrium than in the right atrium as judged by use of spectral entropy