975 research outputs found

    -Makes a Girl Healthy

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    If you could stand on the Knoll some morning when the chimes are playing, and watch the girls hurrying from the halls and houses; or, if you could stand on the top steps of Central building some noon and see them rush by in every direction; or, again, if you would come out to the playground at 4 o\u27clock in the afternoon and watch them playing baskets to hit the bull\u27s eye four times out of five

    Girls; Why Are You Going to College?

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    Girls - all of you girls who are attending Iowa State College-what are you going to college for? Have you a purpose or aim in mind~ Have you a goal set? Or are you merely going to college because your friends are going - or because it is easier than holding a job, or because you haven\u27t thought of anything better to do? Do you have a good reason for going to college? If you haven\u27t - get one right away

    Gas and Electric Short Course

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    Twenty-one million women of the United States are engaged in largest and most important industry in the world, that of homemaking. And yet, it is this· industry which has been slower than others in accepting the modern equipment provided for it. Realizing this, Iowa State College offered a Home Economics Short Course in Gas and Electrical Equipment from March 19 to 24 to people interested in these equipment problems of the homemaker

    Reconciliation and Justification

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    Only he can understand the concept reconciliation who has experienced the implications of the separation between God and man and between man and God. He who ignores this mysterium iniquitatis and refuses to see the wide chasm between the holy God and the guilty creature cannot comprehend the glory of the concept atonement, but on the contrary will in a rebellious spirit be offended at it

    Tort Law - Uniform Contribution among Tortfeasors Act - Comparative Negligence Act

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    The Pennsylvania Supreme Court has held that the Comparative Negligence Act has modified the Uniform Contribution Among Tortfeasors Act to require a non-settling tortfeasor to pay his full pro rata share of damages, notwithstanding the fact that the consideration paid by the settling tortfeasor for a release from the plaintiff exceeds the settling tortfeasor\u27s jury determined pro rata share of damages. Charles v. Giant Eagle Markets, 513 Pa. 474, 522 A.2d 1 (1987)

    Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.

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    Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral constituent from Helichrysum italicum. We have now investigated the activity of arzanol on the biosynthesis of pro-inflammatory eicosanoids, evaluating its anti-inflammatory efficacy in vitro and in vivo. Arzanol inhibited 5-lipoxygenase (EC 7.13.11.34) activity and related leukotriene formation in neutrophils, as well as the activity of cyclooxygenase (COX)-1 (EC 1.14.99.1) and the formation of COX-2-derived prostaglandin (PG)E(2)in vitro (IC(50)=2.3-9μM). Detailed studies revealed that arzanol primarily inhibits microsomal PGE(2) synthase (mPGES)-1 (EC 5.3.99.3, IC(50)=0.4μM) rather than COX-2. In fact, arzanol could block COX-2/mPGES-1-mediated PGE(2) biosynthesis in lipopolysaccharide-stimulated human monocytes and human whole blood, but not the concomitant COX-2-derived biosynthesis of thromboxane B(2) or of 6-keto PGF(1α), and the expression of COX-2 or mPGES-1 protein was not affected. Arzanol potently suppressed the inflammatory response of the carrageenan-induced pleurisy in rats (3.6mg/kg, i.p.), with significantly reduced levels of PGE(2) in the pleural exudates. Taken together, our data show that arzanol potently inhibits the biosynthesis of pro-inflammatory lipid mediators like PGE(2)in vitro and in vivo, providing a mechanistic rationale for the anti-inflammatory activity of H. italicum, and a rationale for further pre-clinical evaluation of this novel anti-inflammatory lead

    Otolith shape and microchemistry revealing life history traits of introduced Chinook Salmon in Patagonia

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    Biological invasions can drastically alter aquatic ecosystems and the societies that depend on them. Human activities propagate non-native species both intentionally and accidentally, which in some cases eliminate native species, while in other cases they may coexist or the invasive may never succeed. This begs the question, why are some species successful invaders while others are not? In southern Chile and Argentina (Patagonia) introduced salmon and trout support commercial and recreational industries and attract anglers from around the world. Introduced Chinook Salmon (Oncorhynchus tshawytscha) in particular are genetically diverse due to multiple propagations and hybridization, and have high variation in population structure, size, and behavioral traits. Yet, few studies have documented specific life history traits contributing to the success of Chinook Salmon in Patagonia. Here, we will use the otolith morphology of Chinook Salmon to contrast among introduced populations in South America, and hatchery origin fish and wild populations in Oregon. Because these two regions have similar environmental conditions, physiography, and latitudes, we can compare across different origin Chinook Salmon. In addition, otolith microchemistry will identify life history strategies (e.g., ocean versus stream type) among multiple introduced populations along a latitudinal gradient in Patagonia. Determining specific life history characteristics of Chinook Salmon in novel systems like Patagonia will help to better understand conservation strategies for wild and hatchery fish in their native range in the Pacific Northwest. Sampling efforts will involve a network of local collaborators of scientists, volunteers, and anglers in Chile and Argentina as well as collaboration with Oregon Department of Fish and Wildlife for otolith samples in Oregon. This research has implications for future scenarios as Patagonia may face climate change and competition among native and non-native species, and will develop management tools for salmonid populations in South America and elsewhere.Fil: Koeberle, Alex. State University of Oregon; Estados UnidosFil: Arismendi, Iván. State University of Oregon; Estados UnidosFil: Di Prinzio, Cecilia Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigación Esquel de Montaña y Estepa Patagónica; ArgentinaOregon Chapter 54th Annual Meeting: Research and Management in a Changing ClimateOregonEstados UnidosAmerican Fisheries Society. Oregon Chapte

    Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo.

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    Myrtucommulone a nonprenylated acylphloroglucinol contained in the leaves of myrtle (Myrtus communis), has been reported to suppress the biosynthesis of eicosanoids by inhibition of 5-lipoxygenase and cyclooxygenase-1 in vitro and to inhibit the release of elastase and the formation of reactive oxygen species in activated polymorphonuclear leukocytes. Here, in view of the ability of MC to suppress typical proinflammatory cellular responses in vitro, we have investigated the effects of MC in in vivo models of inflammation. MC was administered to mice intraperitoneally, and paw edema and pleurisy were induced by the subplantar and intrapleural injection of carrageenan, respectively. MC (0.5, 1.5, and 4.5 mg/kg i.p.) reduced the development of mouse carrageenan-induced paw edema in a dose-dependent manner. Moreover, MC (4.5 mg/kg i.p. 30 min before and after carrageenan) exerted anti-inflammatory effects in the pleurisy model. In particular, 4 h after carrageenan injection in the pleurisy model, MC reduced: 1) the exudate volume and leukocyte numbers; 2) lung injury (histological analysis) and neutrophil infiltration (myeloperoxidase activity); 3) the lung intercellular adhesion molecule-1 and P-selectin immunohistochemical localization; 4) the cytokine levels (tumor necrosis factor-α and interleukin-1 β in the pleural exudate and their immunohistochemical localization in the lung; 5) the leukotriene B 4, but not prostaglandin E2, levels in the pleural exudates; and 6) lung peroxidation (thiobarbituric acid-reactant substance) and nitrotyrosine and poly (ADP-ribose) immunostaining. In conclusion, our results demonstrate that MC exerts potent anti-inflammatory effects in vivo and offer a novel therapeutic approach for the management of acute inflammation. Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics

    Exceptional Points for Nonlinear Schroedinger Equations Describing Bose-Einstein Condensates of Ultracold Atomic Gases

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    The coalescence of two eigenfunctions with the same energy eigenvalue is not possible in Hermitian Hamiltonians. It is, however, a phenomenon well known from non-hermitian quantum mechanics. It can appear, e.g., for resonances in open systems, with complex energy eigenvalues. If two eigenvalues of a quantum mechanical system which depends on two or more parameters pass through such a branch point singularity at a critical set of parameters, the point in the parameter space is called an exceptional point. We will demonstrate that exceptional points occur not only for non-hermitean Hamiltonians but also in the nonlinear Schroedinger equations which describe Bose-Einstein condensates, i.e., the Gross-Pitaevskii equation for condensates with a short-range contact interaction, and with additional long-range interactions. Typically, in these condensates the exceptional points are also found to be bifurcation points in parameter space. For condensates with a gravity-like interaction between the atoms, these findings can be confirmed in an analytical way
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