101 research outputs found
Reactivity of CA19-9 and CA125 in Histological Subtypes of Epithelial Ovarian Tumors and Ovarian Endometriosis
Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility
<Abstract of published report>Effects of a Newly Synthesized Leukotriene Antagonist, NZ-107,on Immediate-Type Hypersensitivity Reaction in Rats and Guinea-Pigs.
<Abstract of published report>Effect of a Newly Synthesized Leukotriene Antagonist, (E)-2,2-Diethyl-3\u27-2-2-(4-Isopropyl)Thiazolyl Ethenyl Succinanilic Acid (MCI-826), on Immunological Liver Injury and Nephritis in Mice.
<Abstract of annual report>Inhibitory effect of β-adrenergic stimulants on increased vascular permeability caused by passive cutaneous anaphylaxis, allergic mediators, and mediator releasers in rats.
<Abstract of published report>Leukotriene Receptors in the Skin of Rats differ from those of Mouse Skin or Rat Stomach Strip.
<Abstract of published report>Effect of CV-3988,a specific antagonist against platelet activating factor, on homologous passive cutaneous anaphylaxis in the mouse ear.
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