Proceedings from the First Annual Society for NeuroSports Conference

Proceedings from the First Annual Society for NeuroSports Conferenc

Proceedings from the Second Annual Society for NeuroSports Conference

Proceedings from the Second Annual Society for NeuroSports Conferenc

Improving zero-error classical communication with entanglement

Given one or more uses of a classical channel, only a certain number of messages can be transmitted with zero probability of error. The study of this number and its asymptotic behaviour constitutes the field of classical zero-error information theory, the quantum generalisation of which has started to develop recently. We show that, given a single use of certain classical channels, entangled states of a system shared by the sender and receiver can be used to increase the number of (classical) messages which can be sent with no chance of error. In particular, we show how to construct such a channel based on any proof of the Bell-Kochen-Specker theorem. This is a new example of the use of quantum effects to improve the performance of a classical task. We investigate the connection between this phenomenon and that of ``pseudo-telepathy'' games. The use of generalised non-signalling correlations to assist in this task is also considered. In this case, a particularly elegant theory results and, remarkably, it is sometimes possible to transmit information with zero-error using a channel with no unassisted zero-error capacity.Comment: 6 pages, 2 figures. Version 2 is the same as the journal version plus figure 1 and the non-signalling box exampl

Assessing a Novel Adaptation to CCI Devices to Model Human Mild Traumatic Brain Injury

Background: Traumatic Brain Injuries (TBIs) are a health crisis with over a million people suffering injuries each year in the United States. The majority of TBIs are mild injuries which often produce no period of unconsciousness and no gross damage to the brain or skull. A range of TBI animal models exist but many produce injuries too severe to characterize as mild. One TBI induction method commonly used is Controlled Cortical Impact (CCI) devices. New Method: The purpose of this study is to assess a novel adaptation to CCI devices that allows for the induction of mild injuries that mimic human mild TBI (mTBI). In this apparatus, the mouse is placed on an elevated platform which utilizes a sensor to collapse the platform as the impactor hits the head. Results: On the first day of injury, the repetitive dropping platform group had a significantly lower Time to Righting (TTR) than both control and single hit stationary platform groups. Additionally, on the first day of injury the single-hit stationary group had a significantly increased Time to Ambulation (TTA) compared to all other groups. Furthermore, this adaptation produces significantly less GFAP than CCI injuries performed without the falling platform. Comparison with existing models: This model incorporates the high control of the CCI device that may be lost in weight-drop models of mild injury while also producing translational mild injuries. Conclusion: This adaptation can be used in any CCI research lab to translationally study mild injuries. This will facilitate murine research into mTBI

Effects and Propositions

The quantum logical and quantum information-theoretic traditions have exerted an especially powerful influence on Bub's thinking about the conceptual foundations of quantum mechanics. This paper discusses both the quantum logical and information-theoretic traditions from the point of view of their representational frameworks. I argue that it is at this level, at the level of its framework, that the quantum logical tradition has retained its centrality to Bub's thought. It is further argued that there is implicit in the quantum information-theoretic tradition a set of ideas that mark a genuinely new alternative to the framework of quantum logic. These ideas are of considerable interest for the philosophy of quantum mechanics, a claim which I defend with an extended discussion of their application to our understanding of the philosophical significance of the no hidden variable theorem of Kochen and Specker.Comment: Presented to the 2007 conference, New Directions in the Foundations of Physic

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

The dissociation of temporal processing behavior in concussion patients: Stable motor and dynamic perceptual timing.

Temporal processing is an integral aspect of human cognition and perception. Recent studies have suggested that patients suffering from concussion exhibit a deficit in temporal processing, characterized by poor performance on a variety of timing tasks. However, the majority of studies focusing on temporal processing deficits in concussion have focused on visual timing mechanisms. As temporal processing may be dominant for auditory-based processing, and so less susceptible to noise, we investigated patients with TBI and compared them to normal healthy controls on a battery of temporal processing tasks, including paced finger tapping and temporal bisection with sub-second intervals. The results of our investigation found that traumatic brain patients were unimpaired on the paced finger tapping task, suggesting that temporal processing deficits do not extend into motor timing and rhythmicity domain. In the temporal bisection task, TBI patients maintained precision but had a significantly higher bisection point, characterized by a greater propensity to judge stimuli as short and were significantly slower than controls. Analysis with a drift-diffusion model of perceptual decision-making revealed that TBI patients were specifically impaired in evidence accumulation, suggesting a smaller signal to noise ratio. Specifically, it demonstrated that patients had higher decision threshold and slower drift rates for accumulating evidence in order to arrive at a decision. Patients had to surmount higher evidence thresholds to reach a decision and were slower than controls in their rate of evidence accumulation. These results suggest specific deficits in temporal perceptual decision-making may predict the neural temporal pathways that may be compromised or unaffected, paving the way for designing targeted therapies to address these impairments