FORMULATION AND EVALUATION OF IBUPROFEN GASTRO-RETENTIVE FLOATING TABLETS

Objective: The objective of the present study was to formulate the gastro-retentive floating tablets containing Ibuprofen, which would remain in stomach and/or upper part of GIT for prolonged period of time. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. Ibuprofen is an anti inflammatory drug.   Methods: On trial and error basis formulation design was done. Four different batches of floating tablets of Ibuprofen were prepared using HPMC, Xanthan gum, and gas generating agent sodium bicarbonate and citric acid. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and 13 hrs in-vitro drug release studies and the results were within the limits. Results: There was no interaction found in between drug and other ingredients. Maximum release was shown by formulation of batch F4 (47.38%), and minimum by the formulations of batch F2 (34.46%) in the duration of 13 hrs. Conclusion: From the results obtained, it was concluded that the optimized formulation F4 desired drug release properties and floating behavior.      Peer Review History: Received 13 June 2018;   Revised 26 August; Accepted 3 September, Available online 15 September 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 2/10 Average Peer review marks at publication stage: 7/10 Reviewer(s) detail: Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, [email protected] Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected] Similar Articles: DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVERY DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM This article has been cited by: Sachin Sarashetti, Vikas Jain, Gowda D V, Pooja Mallya, & Satish Babu. (2020). Recent developments in orally disintegrating mini tablets. International Journal of Research in Pharmaceutical Sciences, 11(3), 3606-3612. Pubme