A Proposal for a Comprehensive Restructuring of the Public Information System

After more than ten years of legislative, judicial and bureaucratic tinkering, the public information system created by the Freedom of Information Act (FOIA) is still far from satisfactory. The present public information system has not been successful because its drafters lacked imagination and failed to do the basic work necessary to create a sound foundation for such a comprehensive program. They failed to analyze the realistic goals of a public information system; they ignored the ultimate goals of improved government performance; they misrepresented the system\u27s costs, both in monetary expense to taxpayers and in diminished government performance. They considered neither alternative techniques nor the problem of designing the public information system as an integral part of the total governmental structure. Actual open government for the benefit of the general populace will be possible only if the basic weaknesses of the present system are explored in depth. This Article is an appeal to Congress to undertake the careful analysis necessary to construct a workable, useful public information system

A Detection of Gas Associated with the M 31 Stellar Stream

Detailed studies of stellar populations in the halos of the Milky Way and the Andromeda (M 31) galaxies have shown increasing numbers of tidal streams and dwarf galaxies, attesting to a complicated and on-going process of hierarchical structure formation. The most prominent feature in the halo of M 31 is the Giant Stellar Stream, a structure ~4.5 degrees in extent along the sky, which is close to, but not coincident with the galaxy's minor axis. The stars that make up this stream are kinematically and chemically distinct from the other stars in the halo. Here, we present HST/COS high-resolution ultraviolet absorption spectra of three Active Galactic Nuclei sight lines which probe the M 31 halo, including one that samples gas in the main southwestern portion of the Giant Stream. We see two clear absorption components in many metal species at velocities typical of the M 31 halo and a third, blue-shifted component which arises in the stream. Photoionization modeling of the column density ratios in the different components shows gas in an ionization state typical of that seen in other galaxy halo environments and suggests solar to slightly super-solar metallicity, consistent with previous findings from stellar spectroscopy.Comment: 10 pages, 5 figures, accepted for publication in the Astrophysical Journa

Wood for Structural and Architectural Purposes

This paper reports the findings and conclusions of Panel II on Structural Purposes, Committee on Renewable Resources for Industrial Materials (CORRIM), National Academy of Sciences/National Research Council. The Panel examined the use of wood for structural purposes and its conversion from standing trees to primary structural commodities as of 1970, and from this base year developed projections of use to the years 1985 and 2000. Concerns of the Panel included the availability of the renewable resource, the demand for wood products, and particularly the costs in terms of manpower, energy, and capital depreciation involved in production and transportation to the point of use. Comparable data from source to end commodity were compiled for other structural materials including steel, aluminum, concrete, brick, and petrochemical derivatives.Wood products were found, with few exceptions, to be more homogeneous than nonwood-based commodities in man-hour and capital requirements. However, the most notable differences between wood-based and nonwood-based commodities are in their energy requirements. Commodities based on nonrenewable resources are appreciably more energy intensive per ton of product than are their wood-based counterparts. In part, this is the result of energy self-sufficiency in the manufacturing process attained through the use of wood residues as fuel

Phenotype to genotype using forward-genetic Mu-seq for identification and functional classification of maize mutants

In pursuing our long-term goals of identifying causal genes for mutant phenotypes in maize, we have developed a new, phenotype-to-genotype approach for transposon-based resources, and used this to identify candidate genes that co-segregate with visible kernel mutants. The strategy incorporates a redesigned Mu-seq protocol (sequence-based, transposon mapping) for high-throughput identification of individual plants carrying Mu insertions. Forward-genetic Mu-seq also involves a genetic pipeline for generating families that segregate for mutants of interest, and grid designs for concurrent analysis of genotypes in multiple families. Critically, this approach not only eliminates gene-specific PCR genotyping, but also profiles all Mu-insertions in hundreds of individuals simultaneously. Here, we employ this scalable approach to study 12 families that showed Mendelian segregation of visible seed mutants. These families were analyzed in parallel, and 7 showed clear co-segregation between the selected phenotype and a Mu insertion in a specific gene. Results were confirmed by PCR. Mutant genes that associated with kernel phenotypes include those encoding: a new allele of Whirly1 (a transcription factor with high affinity for organellar and single-stranded DNA), a predicted splicing factor with a KH domain, a small protein with unknown function, a putative mitochondrial transcription-termination factor, and three proteins with pentatricopeptide repeat domains (predicted mitochondrial). Identification of such associations allows mutants to be prioritized for subsequent research based on their functional annotations. Forward-genetic Mu-seq also allows a systematic dissection of mutant classes with similar phenotypes. In the present work, a high proportion of kernel phenotypes were associated with mutations affecting organellar gene transcription and processing, highlighting the importance and non-redundance of genes controlling these aspects of seed development

Modelling quasicrystals at positive temperature

We consider a two-dimensional lattice model of equilibrium statistical mechanics, using nearest neighbor interactions based on the matching conditions for an aperiodic set of 16 Wang tiles. This model has uncountably many ground state configurations, all of which are nonperiodic. The question addressed in this paper is whether nonperiodicity persists at low but positive temperature. We present arguments, mostly numerical, that this is indeed the case. In particular, we define an appropriate order parameter, prove that it is identically zero at high temperatures, and show by Monte Carlo simulation that it is nonzero at low temperatures

Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity

Selection on running capacity has created rat phenotypes of high‐capacity runners (HCRs) that have enhanced cardiac function and low‐capacity runners (LCRs) that exhibit risk factors of metabolic syndrome. We analysed hearts of HCRs and LCRs from generation 22 of selection using DIGE and identified proteins from MS database searches. The running capacity of HCRs was six‐fold greater than LCRs. DIGE resolved 957 spots and proteins were unambiguously identified in 369 spots. Protein expression profiling detected 67 statistically significant ( p <0.05; false discovery rate <10%, calculated using q ‐values) differences between HCRs and LCRs. Hearts of HCR rats exhibited robust increases in the abundance of each enzyme of the β‐oxidation pathway. In contrast, LCR hearts were characterised by the modulation of enzymes associated with ketone body or amino acid metabolism. LCRs also exhibited enhanced expression of antioxidant enzymes such as catalase and greater phosphorylation of α B‐crystallin at serine 59, which is a common point of convergence in cardiac stress signalling. Thus, proteomic analysis revealed selection on low running capacity is associated with perturbations in cardiac energy metabolism and provided the first evidence that the LCR cardiac proteome is exposed to greater oxidative stress.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86916/1/3369_ftp.pd

Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation

SummaryMaximal exercise-associated oxidative capacity is strongly correlated with health and longevity in humans. Rats selectively bred for high running capacity (HCR) have improved metabolic health and are longer-lived than their low-capacity counterparts (LCR). Using metabolomic and proteomic profiling, we show that HCR efficiently oxidize fatty acids (FAs) and branched-chain amino acids (BCAAs), sparing glycogen and reducing accumulation of short- and medium-chain acylcarnitines. HCR mitochondria have reduced acetylation of mitochondrial proteins within oxidative pathways at rest, and there is rapid protein deacetylation with exercise, which is greater in HCR than LCR. Fluxomic analysis of valine degradation with exercise demonstrates a functional role of differential protein acetylation in HCR and LCR. Our data suggest that efficient FA and BCAA utilization contribute to high intrinsic exercise capacity and the health and longevity benefits associated with enhanced fitness

Direct-Current Induced Dynamics in Co90Fe10/Ni80Fe20 Point Contacts

We have directly measured coherent high-frequency magnetization dynamics in ferromagnet films induced by a spin-polarized DC current. The precession frequency can be tuned over a range of several gigahertz, by varying the applied current. The frequencies of excitation also vary with applied field, resulting in a microwave oscillator that can be tuned from below 5 GHz to above 40 GHz. This novel method of inducing high-frequency dynamics yields oscillations having quality factors from 200 to 800. We compare our results with those from single-domain simulations of current-induced dynamics

Description of a new deep-water dogfish shark from Hawaii, with comments on the Squalus mitsukurii species complex in the West Pacific

Dogfish sharks of the genus Squalus are small, deep-water sharks with a slow rate of molecular evolution that has led to their designation as a series of species complexes, with low between-species diversity relative to other taxa. The largest of these complexes is named for the Shortspine spurdog (Squalus mitsukurii Jordan &amp;amp; Snyder), a medium-sized dogfish shark common to warm upper slope and seamount habitats, with a putative circumglobal distribution that has come under investigation recently due to geographic variation in morphology and genetic diversity. The Hawaiian population of Squalus mitsukurii was examined using both morphological and molecular analyses, putting this group in an evolutionary context with animals from the type population in Japan and closely-related congeners. External morphology differs significantly between the Hawaiian and Japanese S. mitsukurii, especially in dorsal fin size and relative interdorsal length, and molecular analysis of 1,311 base pairs of the mitochondrial genes ND2 and COI show significant, species-level divergence on par with other taxonomic studies of this genus. The dogfish shark in Hawaii represents a new species in the genus, and the name Squalus hawaiiensis, the Hawaiian spurdog, is designated after the type location