385 research outputs found
Design aesthetics recommender system based on customer profile and wanted affect
Product recommendation systems have been instrumental in online commerce
since the early days. Their development is expanded further with the help of
big data and advanced deep learning methods, where consumer profiling is
central. The interest of the consumer can now be predicted based on the
personal past choices and the choices of similar consumers. However, what is
currently defined as a choice is based on quantifiable data, like product
features, cost, and type. This paper investigates the possibility of profiling
customers based on the preferred product design and wanted affects. We
considered the case of vase design, where we study individual Kansei of each
design. The personal aspects of the consumer considered in this study were
decided based on our literature review conclusions on the consumer response to
product design. We build a representative consumer model that constitutes the
recommendation system's core using deep learning. It asks the new consumers to
provide what affect they are looking for, through Kansei adjectives, and
recommend; as a result, the aesthetic design that will most likely cause that
affect.Comment: 11 pages, 10 figures, peer-reviewed at the KEER 2022 conferenc
Simultaneous flood risk analysis and its future change among all the 109 class-A river basins in Japan using a large ensemble climate simulation database d4PDF
This study investigated simultaneous flood risk among all the 109 class-A river basins over Japan using the big data of (over 1000 years) annual maximum hourly flow simulated from a large ensemble climate simulation database for policy decision making for future climate change, and proposed a novel approach in its geospatial analysis by applying two informatics techniques: the association rule analysis and graph theory. Frequency analysis of the number of rivers with the annual maximum flow over the flow capacity in the same year (defined as simultaneous flooding here) indicated that simultaneous flood risk will increase in the future climate under 4-degree rise scenarios in Japan, whose increment is larger than the variation of sea surface temperature projections. As the result, the return period of simultaneous flooding in eight river basins (the same number as in a severe storm in western Japan, 2018, causing the second worst economic damage since 1962) is estimated at 400 years in the historical experiment, 25 years in the 4-degree rise experiment. The association rule and graph theory analyses for the big data of annual maximum flows in the future climate scenarios indicated that simultaneous flood occurrence is dominated by spatial distance at a national scale as well as by the spatial relation between mountainous ridges and typhoon courses at a regional scale. Large ensemble climate simulation data combined with the informatics technology is a powerful approach to simultaneous flood risk analysis
Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 cases of thyroid MALT lymphoma using paraffin-embedded, formalin-fixed tissue specimens. In all cases of thyroid MALT lymphoma, human Tg was detected immunohistochemically in the follicular epithelial cells and follicular dendritic cells (FDCs). These FDCs were positive by double immunostaining for anti-human Tg rabbit polyclonal antibody (Ab) and for CD35. Results showed that the Tg, a thyroid autoantigen, had immunostained the germinal center of the thyroid MALT lymphoma. The Tg was present in the FDCs, as revealed by the staining pattern of the germinal center;this fact was confirmed by double immunostaining of anti-human Tg mouse monoclonal Ab and anti-CD35 mouse monoclonal Ab. The results of our study suggest that Tg is an autoantigen that is recognized by thyroid MALT lymphoma cells.</p
Oral healthcare systems for an ageing population: concepts and challenges
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138847/1/idj12343_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138847/2/idj12343.pd
Antibody and Cytokine Responses in Helicobacter pylori-Infected Various Mouse Strains
Helicobacter pylori (H. pylori) infection in the stomach is etiologically closely associated with chronic active gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. In this study, we examined the antibody responses and cytokine profiles of three strains of mice (BALB/c, C3H/He, and C57BL/6) infected with H. pylori. Following this, correlations between host-immune reactions and intensity of inflammation were analyzed. H. pylori (ATCC43504) was intragastrically administered once a week to the mice from 4 weeks of age, and they were sacrificed at the ages of 4 and 7 months. In these mice, we examined the histology of the stomach, antibody titers against H. pylori, and serum levels of cytokines (IL-4, IL-10, TNF-alpha, IL-2 and Interferon-gamma). In BALB/c mice, inflammation of the stomach was minimal. Inflammation was observed in 63.6% of C57BL/6 mice and 33.3% of C3h/He mice. In C57BL/6 and C3H/He mice, all the cytokines tended to increase. In contrast, BALB/c mice were inactive in cytokine production except for IL-2. Two C3H/He mice developed severe inflammation with lymph follicles; one showed a response largely typical of Th-1, and the other showed a response largely typical of Th-2. Although a definite correlation was not shown between Th-1/Th-2 response evaluated by cytokine production and intensity of inflammation, it appears that in H. pylori-induced inflammation both cell-mediated (Th-1) and humoral (Th-2) immunity play a role in pathogenesis.</p
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