出土文字資料よりみた秦の徭役

早大学位記番号:新8001早稲田大

Study of the effect of mechanical impact parameters on an impact-mode piezoelectric ceramic power generator

This paper presents an analytical and experimental study on the effect of mechanical impact parameters on impact-mode piezoelectric ceramic power generators. The parameters are the velocity and mass. The method of analysis is based on a weight drop experiment. The results show that the peak of the instantaneous output voltage is proportional to the impact velocity, and for the output power, it is in a straight line relationship with the same parameter. For the same velocity of impact, the advantage of using heavy objects is clear because its momentum and the impact force are higher. However, an adjustment in the velocity of impact is found to be more effective for higher instantaneous output power than the mass. This finding is supported by the output power that is generated by a 4-g steel ball with a momentum of 4.34 gm/s, which is almost 300% higher than that of an 8-g steel ball for the same momentum. The frequency responses of a vibration-based impact-mode piezoelectric ceramic power generator also support the same conclusion

The Effect of the Parameters of a Vibration-Based Impact Mode Piezoelectric Power Generator

This study reports the effects of the parameters of a vibration-based impactmode piezoelectric power generator. First, an evaluation of the effects of the impact parameters, the mass, and the impact velocity is presented. It is found that the output voltage of the piezoelectric device in impactmode is directly proportional to the velocity,whereas the output power is equal to a quadratic function of the same variable. For the same impact momentum, the effect of the velocity in generating a higher peak output is dominant compared with the mass. Second, the vibration-based impact mode piezoelectric power generator is discussed. The experimental results show that a wider operating frequency bandwidth of the output power can be achieved with the preloading configuration. However, regardingmagnitude, due to the high velocity of impact, the configurationwith a gap between the tip and the piezoelectric device produces a higher output

Festchrift: A Collection of Essays on Architectural History

A collection of essays on architectural history prepared by the Northern Pacific Coast Chapter Society of Architectural Historians dedicated to Professor Marion Dean Ross, chapter founder, on the occasion of his 65th birthday

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge. We aimed to identify pathogenic or likely pathogenic variants in CCSD patients by using WES and 2015 American College of Medical Genetics and Genomics (ACMG) standards and guidelines as well as evaluating the usefulness of functional studies for determining them. Methods and Results We performed WES of 23 probands diagnosed with early-onset (<65 years) CCSD and analyzed 117 genes linked to arrhythmogenic diseases or cardiomyopathies. We focused on rare variants (minor allele frequency < 0.1%) that were absent from population databases. Five probands had protein truncating variants in EMD and LMNA which were classified as “pathogenic” by 2015 ACMG standards and guidelines. To evaluate the functional changes brought about by these variants, we generated a knock-out zebrafish with CRISPR-mediated insertions or deletions of the EMD or LMNA homologs in zebrafish. The mean heart rate and conduction velocities in the CRISPR/Cas9-injected embryos and F2 generation embryos with homozygous deletions were significantly decreased. Twenty-one variants of uncertain significance were identified in 11 probands. Cellular electrophysiological study and in vivo zebrafish cardiac assay showed that 2 variants in KCNH2 and SCN5A, 4 variants in SCN10A, and 1 variant in MYH6 damaged each gene, which resulted in the change of the clinical significance of them from “Uncertain significance” to “Likely pathogenic” in 6 probands. Conclusions Of 23 CCSD probands, we successfully identified pathogenic or likely pathogenic variants in 11 probands (48%). Functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants in patients with CCSD. SCN10A may be one of the major genes responsible for CCSD. Translational Perspective Whole-exome sequencing (WES) may be helpful in determining the causes of cardiac conduction system disease (CCSD), however, the identification of pathogenic variants remains a challenge. We performed WES of 23 probands diagnosed with early-onset CCSD, and identified 12 pathogenic or likely pathogenic variants in 11 of these probands (48%) according to the 2015 ACMG standards and guidelines. In this context, functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants, and SCN10A may be one of the major development factors in CCSD

岳麓書院蔵秦簡「秦律令(壹)」徭律訳注(二)

departmental bulletin pape

岳麓書院蔵秦簡「秦律令(壹)」徭律訳注(一)

departmental bulletin pape