Crystal structure of 3-(4-bromophenyl)-5-methyl-1 H -pyrazole, C 10 H 9 BrN 2

C10H9BrN2, orthorhombic, P212121 (no. 19), a = 5.9070(3) Å, b = 9.2731(7) Å, c = 17.5641(14) Å, V = 962.09(12) Å3 , Z = 4, Rgt(F) = 0.0504, wRref(F2 ) = 0.0947, T = 293(2) K

Crystal structure of 4-bromo-3-nitro-1H-pyrazole-5-carboxylic acid monohydrate, C4H2N3BrO4·H2O

C4H2N3BrO4·H2O, monoclinic, P21/c (no. 14), a = 7.177(2) Å, b = 10.999(3) Å, c = 10.414(3) Å, β = 100.145 (11) °, V = 809.3(4) Å3, Z = 4, Rgt (F) = 0.0379, wRref (F2) = 0.0714, T = 200K © 2023 the author(s), published by De Gruyter, Berlin/Boston

Powder bed fusion–laser beam (PBF-LB) three-dimensional (3D) printing: Influence of laser hatching distance on the properties of zolpidem tartrate tablets

Laser sintering, known as powder bed fusion–laser beam (PBF-LB), offers promising potential for the fabrication of patient-specific drugs. The aim of this study was to provide an insight into the PBF-LB process with regard to the process parameters, in particular the laser hatching distance, and its influence on the properties of zolpidem tartrate (ZT) tablets. PHARMACOAT® 603 was used as the polymer, while Candurin® Gold Sheen and AEROSIL® 200 were added to facilitate 3D printing. The particle size distribution of the powder blend showed that the layer height should be set to 100 µm, while the laser hatching distance was varied in five different steps (50, 100, 150, 200 and 250 µm), keeping the temperature and laser scanning speed constant. Increasing the laser hatching distance and decreasing the laser energy input led to a decrease in the colour intensity, mass, density and hardness of the ZT tablets, while the disintegration and dissolution rate were faster due to the more fragile bonds between the particles. The laser hatching distance also influenced the ZT dosage, indicating the importance of this process parameter in the production of presonalized drugs. The absence of drug-polymer interactions and the amorphization of the ZT were confirmed

Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets

Three-dimensional printing (3DP) is an innovative additive manufacturing technology in the field of pharmaceuticals that has the potential to provide small batches of patient-tailored medicines (Wang et al., 2021). One of the newest and most advanced 3DP techniques is selective laser sintering (SLS), a one-step manufacturing process that uses a laser to selectively sinter powder particles into layers and create a 3D structure of a solid dosage form. Depending on the 3D design of the object, the laser is focused to draw specific patterns on the surface of the powder. Once the first layer is sintered, a fresh layer of powder is sprinkled on top so that a new layer can be sintered (Allahham et al., 2020). The aim of this study was to formulate and investigate the influence of the model design on the properties of zolpidem tartrate (ZT) tablets produced by the SLS 3DP process.14th Central European Symposium on Pharmaceutical Technology, 28th - 30th September, Ohrid, N. Macedonia, 202

Crystal structure of 4-bromo-3-nitro-1H-pyrazole-5-carboxylic acid monohydrate, C4H2N3BrO4·H2O

C4H2N3BrO4·H2O, monoclinic, P21/c (no. 14), a = 7.177(2) Å, b = 10.999(3) Å, c = 10.414(3) Å, β = 100.145(11)∘$100.145{(11)}^{\circ }$, V = 809.3(4) Å3, Z = 4, Rgt${R}_{\mathrm{g}\mathrm{t}}$(F) = 0.0379, wRref$w{R}_{\mathrm{r}\mathrm{e}\mathrm{f}}$(F2) = 0.0714, T = 200 

Formulacija i karakterizacija oralno-disperzibilnih tableta desloratadina dobijenih 3D tehnikom selektivnog laserskog sinterovanja

Trodimenzionalna (3D) štampa predstavlja inovativnu tehnologiju u oblasti farmacije, koja ima potencijal da obezbedi proizvodnju malih serija lekova prilagođenih individualnim potrebama pacijenata. Intenzivno istraživanje u oblasti 3D štampe rezultovalo je razvojem velikog broj različitih tehnika, a čija osnovna, zajednička karakteristika jeste štampanje u slojevima. ...Three-dimensional (3D) printing is an innovative technology in the field of pharmacy with potential to provide manufacturing of small batches of patient-taiIored medicines. Intensive research in the field of 3D printing has resulted in development of numerous different techniques whose common feature is printing in layers The aim of this study was to formulate and comparatively characterize orodispersible tablets (ODTs) of desloratadine (DSL) obtained by 3D selective laser sintering (SLS) technique with commercially available ODTs. ...Book of abstracts - The pover of pharmacy the strength of our healt

Crystal structure of 3-(4-bromophenyl)-5-methyl-1H-pyrazole, C10H9BrN2

C10H9BrN2, orthorhombic, P212121 (no. 19), a = 5.9070(3) Å, b = 9.2731(7) Å, c = 17.5641(14) Å, V = 962.09(12) Å3, Z = 4, Rgt(F) = 0.0504, wRref(F2) = 0.0947, T = 293(2) K

Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique

The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers