Design and Implementation of Storage System Using Byte-index Chunking Scheme

In this paper, we present an enhanced storage system that supports Byte-index chunking algorithm. The storage system aims to provide efficient data deduplication with high performance and to be performed in rapid time. We describe the overall procedure of Byteindex chunking based storage system including read/write procedure and how the system works. The key idea of Byte-index chunking is to adapt fixed-size block chunk scheme which are distributed to “Index-table ” by chunk’s both side boundary values. We have found that Byte-index chunking in storage system provides high performance compared with other chunking schemes. Experiments result shows that the storage system with Byte-index chunking compresses overall data with high deduplication capability and reduce the speed of file processing

Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm

Abdominal aortic aneurysm: Potential enzyme biomarker identified An enzyme with antioxidant properties may provide a biomarker and therapeutic agent to help treat abdominal aortic aneurysm (AAA). AAA involves the structural deterioration of the aorta through chronic inflammation and oxidative stress, and can trigger life-threatening artery rupture. An antioxidant enzyme called peroxiredoxin 2 (PRDX2) is increased in patients with ruptures, but whether its role in AAA is beneficial or detrimental is unclear. Goo Taeg Oh at the Ewha Womans University in Seoul, Jong-Gil Park at the Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea, and co-workers examined the effect of PRDX2 on AAA progression. PRDX2 suppressed structural damage in mice, limiting artery dilation and protein degradation. Loss of PRDX2 accelerated AAA development. Measuring levels of PRDX2 may indicate AAA severity in patients, while boosting the enzyme could repair aortic damage

Mapping rice area and yield in northeastern asia by incorporating a crop model with dense vegetation index profiles from a geostationary satellite

Acquiring accurate and timely information on the spatial distribution of paddy rice fields and the corresponding yield is an important first step in meeting the regional and global food security needs. In this study, using dense vegetation index profiles and meteorological parameters from the Communication, Ocean, and Meteorological Satellite (COMS) geostationary satellite, we estimated paddy areas and applied a novel approach based on a remote sensing-integrated crop model (RSCM) to simulate spatiotemporal variations in rice yield in Northeastern Asia. Estimated seasonal vegetation profiles of plant canopy from the Geostationary Ocean Color Imager (GOCI) were constructed to classify paddy fields as well as their productivity based on a bidirectional reflectance distribution function model (BRDF) and adjusted normalized difference vegetation indices (VIs). In the case of classification, the overall accuracy for detected paddy fields was 78.8% and the spatial distribution of the paddy area was well represented for each selected county based on synthetic applications of dense-time GOCI vegetation index and MODIS water index. For most of the Northeast Asian administrative districts investigated between 2011 and 2017, simulated rice mean yields for each study site agreed with the measured rice yields, with a root-mean-square error of 0.674 t ha−1, a coefficient of determination of 0.823, a Nash-Sutcliffe efficiency of 0.524, and without significant differences (p-value = 0.235) according to a sample t-test (α = 0.05) for the entire study period. A well-calibrated RSCM, driven by GOCI images, can facilitate the development of novel approaches for the monitoring and management of crop productivity over classified paddy areas, thereby enhancing agricultural decision support systems

Monitoring paddy productivity in North Korea employing geostationary satellite images integrated with GRAMI-rice model

To meet the growing demands of staple crops with a strategy to develop amicable strategic measures that support efficient North Korean relief policies, it is a desirable task to accurately simulate the yield of paddy (Oryza sativa), an important Asian food commodity. We aim to address this with a gridbased crop simulation model integrated with satellite imagery that enables us to monitor the crop productivity of North Korea. Vegetation Indices (VIs), solar insolation, and air temperature data are thus obtained from the Communication Ocean and Meteorological Satellite (COMS), including the reanalysis data of the Korea Local Analysis and Prediction System (KLAPS). Paddy productivities for North Korea are projected based on the bidirectional reflectance distribution function-adjusted VIs and the solar insolation using the grid GRAMI-rice model. The model is calibrated on a 500-m grid paddy field in Cheorwon, and the model simulation performance accuracy is verified for Cheorwon and Paju, located at the borders of North Korea using four years of data from 2011 to 2014. Our results show that the paddy yields are reproduced reasonably accurately within a statistically significant range of accuracy, in comparison with observation data in Cheorwon (p = 0.183), Paju (p = 0.075), and NK (p = 0.101) according to a statistical t-test procedure. We advocate that incorporating a crop model with satellite images for crop yield simulations can be utilised as a reliable estimation technique for the monitoring of crop productivity, particularly in unapproachable, data-sparse regions not only in North Korea, but globally, where estimations of paddy productivity can assist in planning of agricultural activities that support regionally amicable food security strategies

The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition

Backgroundβ-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility has been suggested that sulfonylurea, currently being used as one of the main oral hypoglycemic agents of type 2 diabetes, increases ER stress, which could lead to sulfonylurea failure. The authors of the present study examined ER stress of β-cells in a glucolipotoxic condition using glyburide (GB) in an environment mimicking type 2 diabetes.MethodsApoptosis was induced by adding various concentrations of GB (0.001 to 200 µM) to a glucolipotoxic condition using 33 mM glucose, and the effects of varied concentrations of palmitate were evaluated via annexin V staining. The markers of ER stress and pro-apoptotic markers were assessed by Western blotting and semi-quantitative reverse transcription-polymerase chain reaction. Additionally, the anti-apoptotic markers were evaluated.ResultsAddition of any concentration of GB in 150 µM palmitate and 33 mM glucose did not increase apoptosis. The expression of phosphorylated eukaryotic initiation factor (eIF-2α) was increased and cleaved caspase 3 was decreased by adding GB to a glucolipotoxic condition. However, other ER stress-associated markers such as Bip-1, X-box binding protein-1, ATF-4 and C/EBP-homologous protein transcription factor and anti-apoptotic markers phosphor-p85 phosphatidylinositol 3-kinase and phosphorylation of Akt did not change significantly.ConclusionGB did not show further deleterious effects on the degree of apoptosis or ER stress of INS-1 cells in a glucolipotoxic condition. Increased phosphorylation of eIF-2α may attenuate ER stress for adaptation to increased ER protein load

Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study

Hyeonggaeyeongyo-tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short-term and long-term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 weeks and had follow-up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events. This improvement lasted during a follow-up period of 8 weeks. Total IgE and eosinophil levels showed no significant difference after treatment in the allergic rhinitis group. HYT improved nasal symptoms and quality of life in patients with allergic rhinitis and nonallergic rhinitis. This is the first clinical study to evaluate the use of HYT to treat patients with rhinitis. This trial has been registered with the ClinicalTrials.gov Identifier NCT02477293