Adult Attention-Deficit Hyperactivity Disorder

Attention-Deficit Hyperactivity Disorder (ADHD) in adults is a valid and impairing disorder for which psychopharmacological and psychosocial treatments are recommended. Self-report ratings scales for adult ADHD can serve several functions in clinical work with this population including screening, providing information, in a comprehensive assessment, and tracking treatment-related change. The use of two symptom-based ratings scales for screening and tracking treatment progress- the Current Symptoms Scale (CSS) [5] and the Adult ADHD Self-Report Scale (ASRS) [6] - is outlined for the practicing clinician. Key issues in the assessment of adult ADHD are briefly discussed, highlighting the role of rating scales within a comprehensive assessment

Psychosocial Treatment of Adults With Attention Deficit Hyperactivity Disorder

In this chapter, we first review the rationale for psychosocial treatment of adults with ADHD. We then focus on treatment programs that have received support in the research literature, highlighting the role of comprehensive assessment. Drawing upon existing interventions, as well as clinical guidelines and our clinical experiences in the Cognitive-Behavioral Therapy Program for Adult ADHD at Massachusetts General Hospital, we present recommendations for psychosocial treatment planning with this population. We conclude with a brief discussion of psychosocial management of comorbid disorders

Psychosocial Treatment for Adult ADHD

Many adults with ADHD are likely to benefit from psychosocial interventions that teach compensatory skills to manage symptoms and address functional impairment. Based on the research literature and the authors’ experience developing and implementing interventions, this chapter provides a practice-friendly overview of skills-based treatment selection and implementation, emphasizing cognitive-behavioral techniques. Principles are illustrated using case examples and adjunctive treatment options are discussed

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

Whole-chromosome copy number alterations, also known as aneuploidy, are associated with adverse consequences in most cells and organisms. However, high frequencies of aneuploidy have been reported to occur naturally in the mammalian liver and brain, fueling speculation that aneuploidy provides a selective advantage in these organs. To explore this paradox, we used single cell sequencing to obtain a genome-wide, high-resolution assessment of chromosome copy number alterations in mouse and human tissues. We find that aneuploidy occurs much less frequently in the liver and brain than previously reported and is no more prevalent in these tissues than in skin. Our results highlight the rarity of chromosome copy number alterations across mammalian tissues and argue against a positive role for aneuploidy in organ function. Cancer is therefore the only known example, in mammals, of altering karyotype for functional adaptation.National Institutes of Health (U.S.). Physical Sciences Oncology Center (Grant 5-U54-CA143874)Ellison Medical Foundation (Senior Scholar Award)National Cancer Institute (U.S.) (Koch Institute. Grant P30-CA14051)Howard Hughes Medical InstituteKathy and Curt Marble Cancer Research Fun

Enantiodivergent Formation of C−P Bonds: Synthesis of P‑Chiral Phosphines and Methylphosphonate Oligonucleotides

Phosphorus Incorporation (PI, abbreviated Π) reagents for the modular, scalable, and stereospecific synthesis of chiral phosphines and methylphosphonate nucleotides are reported. Synthesized from translimonene oxide, this reagent class displays an unexpected reactivity profile and enables access to chemical space distinct from that of the Phosphorus−Sulfur Incorporation reagents previously disclosed. Here, the adaptable phosphorus(V) scaffold enables sequential addition of carbon nucleophiles to produce a variety of enantiopure C−P building blocks. Addition of three carbon nucleophiles to Π, followed by stereospecific reduction, affords useful P-chiral phosphines; introduction instead of a single methyl group reveals the first stereospecific synthesis of methylphosphonate oligonucleotide precursors. While both Π enantiomers are available, only one isomer is requiredthe order of nucleophile addition controls the absolute stereochemistry of the final product through a unique enantiodivergent design