Non-metastatic patient distribution per radiographic evaluation.

<p>Non-metastatic patient distribution per radiographic evaluation.</p

Radiographic Evaluation for Response and Surgical R0 resection rate.

<p>Radiographic Evaluation for Response and Surgical R0 resection rate.</p

Dose volume histogram for the treatment plan with SIB.

<p>Dose volume histogram for the plan with SIB are showing here. The differential dose at the same large areas of CTV illustrated here. The higher dose in the area close to major vessel through SIB without increased the dose to the normal structures. The differential doses at the same areas of clinical tumor volume are illustrated. The mean doses (cGy) are: Gross Tumor Volume 5670; Clinical Tumor Volume 5100; Bowel 2020; Liver 1563; Cord 1380; Lt Kidney 1518; Rt Kidney 1453.</p

Published experience with neoadjuvant approach and R0 resection for localized pancreatic cancer.

<p>Published experience with neoadjuvant approach and R0 resection for localized pancreatic cancer.</p

Characteristics of 25 Patients.

<p>Characteristics of 25 Patients.</p

Axial and coronal images of representative IMRT-SIB.

<p>Treatment plan of using IMRT with SIB for pancreatic cancer summarized in the reprehensive images from treatment. Axial and coronal images of representative IMRT-SIB plans depicting dose wash of 5040 to CTV (pink) and dose escalation of 56 Gy to GTV (red).</p

nab-paclitaxel/carboplatin induction in squamous NSCLC: longitudinal quality of life while on chemotherapy

Background: Longitudinal data on the impact of treatment on quality of life (QoL) in advanced non-small cell lung cancer (NSCLC) are limited. In this palliative setting, treatment that does not deteriorate QoL is key. Here we report longitudinal QoL in patients with squamous NSCLC, receiving ≤4 cycles of Methods: Patients received Results: Two-hundred and six lesion-response-evaluable patients completed baseline + ≥1 postbaseline QoL assessment and were QoL evaluable. LCSS average total score and symptom burden index improved from baseline throughout four cycles. In the LCSS pulmonary symptoms score, 46% of patients reported clinically meaningful improvement (≥10 mm visual analog scale) from baseline. Individual EQ-5D-5L dimensions remained stable/improved in ≥83% of patients; ≈33% reported complete resolution of baseline problems at least once during four cycles. Generally, responders (unconfirmed complete/partial response) had higher scores vs nonresponders. Conclusion: In patients with squamous NSCLC, four cycles o

Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848.

PURPOSE: NRG/Radiation Therapy Oncology Group 0848 is a 2-step randomized trial to evaluate the benefit of the addition of concurrent fluoropyrimidine and radiation therapy (RT) after adjuvant chemotherapy (second step) for patients with resected pancreatic head adenocarcinoma. Real-time quality assurance (QA) was performed on each patient who underwent RT. This analysis aims to evaluate adherence to protocol-specified contouring and treatment planning and to report the types and frequencies of deviations requiring revisions. METHODS AND MATERIALS: In addition to a web-based contouring atlas, the protocol outlined step-by-step instructions for generating the clinical treatment volume through the creation of specific regions of interest. The planning target volume was a uniform 0.5 cm clinical treatment volume expansion. One of 2 radiation oncology study chairs independently reviewed each plan. Plans with unacceptable deviations were returned for revision and resubmitted until approved. Treatment started after final approval of the RT plan. RESULTS: From 2014 to 2018, 354 patients were enrolled in the second randomization. Of these, 160 patients received RT and were included in the QA analysis. Resubmissions were more common for patients planned with 3-dimensional conformal RT (43%) than with intensity modulated RT (31%). In total, at least 1 resubmission of the treatment plan was required for 33% of patients. Among patients requiring resubmission, most only needed 1 resubmission (87%). The most common reasons for resubmission were unacceptable deviations with respect to the preoperative gross target volume (60.7%) and the pancreaticojejunostomy (47.5%). CONCLUSION: One-third of patients required resubmission to meet protocol compliance criteria, demonstrating the continued need for expending resources on real-time, pretreatment QA in trials evaluating the use of RT, particularly for pancreas cancer. Rigorous QA is critically important for clinical trials involving RT to ensure that the true effect of RT is assessed. Moreover, RT QA serves as an educational process through providing feedback from specialists to practicing radiation oncologists on best practices