17 research outputs found
Topical Application of Activity-based Probes for Visualization of Brain Tumor Tissue
Several investigators have shown the utility of systemically delivered optical imaging probes to image tumors in small animal models of cancer. Here we demonstrate an innovative method for imaging tumors and tumor margins during surgery. Specifically, we show that optical imaging probes topically applied to tumors and surrounding normal tissue rapidly differentiate between tissues. In contrast to systemic delivery of optical imaging probes which label tumors uniformly over time, topical probe application results in rapid and robust probe activation that is detectable as early as 5 minutes following application. Importantly, labeling is primarily associated with peri-tumor spaces. This methodology provides a means for rapid visualization of tumor and potentially infiltrating tumor cells and has potential applications for directed surgical excision of tumor tissues. Furthermore, this technology could find use in surgical resections for any tumors having differential regulation of cysteine cathepsin activity
Couple psychoeducation for new parents: Observed and potential effects on parenting
The transition to parenthood is a substantial challenge for many couples, and the extent to which the partners can support each other and their relationship is strongly related to the sensitivity and responsiveness of their parenting of their infant. This paper critically analyses the links between the couple relationship and parenting of infants and reviews the research evaluating couple psychoeducation (CP) to assist couplesâ parenting of their infant. It is concluded that CP has considerable potential to enhance couplesâ adaptation to parenthood and enhance the sensitivity and responsiveness of parenting of new infants. © Springe
The origin of modern terrestrial life
The study of the origin of life covers many areas of expertise and requires
the input of various scientific communities. In recent years, this research
field has often been viewed as part of a broader agenda under the name of
âexobiologyâ or âastrobiology.â In this review,
we have somewhat narrowed this agenda, focusing on the origin of modern terrestrial
life. The adjective âmodernâ here means that we did not speculate
on different forms of life that could have possibly appeared on our planet,
but instead focus on the existing forms (cells and viruses). We try to briefly
present the state of the art about alternative hypotheses discussing not only
the origin of life per se, but also how life evolved
to produce the modern biosphere through a succession of steps that we would
like to characterize as much as possible