372 research outputs found
Cyclin D1 integrates G9a-mediated histone methylation.
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle progression and mitochondrial metabolism. Herein, we show that cyclin D1 enhanced H3K9 dimethylation though direct association with G9a. Endogenous cyclin D1 was required for the recruitment of G9a to target genes in chromatin, for G9a-induced H3K9me2 of histones, and for NL-LAD interaction. The finding that cyclin D1 is required for recruitment of G9a to target genes in chromatin and for H3K9 dimethylation, identifies a novel mechanism coordinating protein methylation
Probing BFKL Dynamics in the Dijet Cross Section at Large Rapidity Intervals in ppbar Collisions at sqrt{s}=1800 and 630 GeV
Inclusive dijet production at large pseudorapidity intervals (delta_eta)
between the two jets has been suggested as a regime for observing BFKL
dynamics. We have measured the dijet cross section for large delta_eta in ppbar
collisions at sqrt{s}=1800 and 630 GeV using the DO detector. The partonic
cross section increases strongly with the size of delta_eta. The observed
growth is even stronger than expected on the basis of BFKL resummation in the
leading logarithmic approximation. The growth of the partonic cross section can
be accommodated with an effective BFKL intercept of
a_{BFKL}(20GeV)=1.65+/-0.07.Comment: Published in Physical Review Letter
Search for Electroweak Production of Single Top Quarks in ppbar Collisions
We present a search for electroweak production of single top quarks in the
electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of
data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with
the DZero detector between 1992 and 1995. We use events that include a tagging
muon, implying the presence of a b jet, to set an upper limit at the 95%
confidence level on the cross section for the s-channel process ppbar->tb+X of
39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb.Comment: 11 pages, 2 figures. This is the published versio
Search for bottom squarks in pbarp collisions at sqrt(s)=1.8 TeV
We report on a search for bottom squarks produced in pbarp collisions at
sqrt(s) = 1.8 TeV using the D0 detector at Fermilab. Bottom squarks are assumed
to be produced in pairs and to decay to the lightest supersymmetric particle
(LSP) and a b quark with branching fraction of 100%. The LSP is assumed to be
the lightest neutralino and stable. We set limits on the production cross
section as a function of bottom squark mass and LSP mass.Comment: 5 pages, Latex. submitted 3-12-1999 to PRD - Rapid Communicatio
Search for Squarks and Gluinos in Events Containing Jets and a Large Imbalance in Transverse Energy
Using data corresponding to an integrated luminosity of 79 pb-1, D0 has
searched for events containing multiple jets and large missing transverse
energy in pbar-p collisions at sqrt(s)=1.8 TeV at the Fermilab Tevatron
collider. Observing no significant excess beyond what is expected from the
standard model, we set limits on the masses of squarks and gluinos and on the
model parameters m_0 and m_1/2, in the framework of the minimal low-energy
supergravity models of supersymmetry. For tan(beta) = 2 and A_0 = 0, with mu <
0, we exclude all models with m_squark < 250 GeV/c^2. For models with equal
squark and gluino masses, we exclude m < 260 GeV/c^2.Comment: 10 pages, 3 figures, Submitted to PRL, Fixed typo on page bottom of
p. 6 (QCD multijet background is 35.4 events
Search for Second Generation Leptoquark Pairs in pbar-p Collisions at sqrt(s) = 1.8 TeV
We have searched for second generation leptoquark (LQ) pairs in the
\mu\mu+jets channel using 94+-5 pb^{-1} of pbar-p collider data collected by
the D0 experiment at the Fermilab Tevatron during 1993-1996. No evidence for a
signal is observed. These results are combined with those from the \mu\nu+jets
and \nu\nu+jets channels to obtain 95% confidence level (C.L.) upper limits on
the LQ pair production cross section as a function of mass and $beta, the
branching fraction of a LQ decay into a charged lepton and a quark. Lower
limits of 200(180) GeV/c^2 for \beta=1(1/2) are set at the 95% C.L. on the mass
of scalar LQ. Mass limits are also set on vector leptoquarks as a function of
\beta.Comment: 6 pages, 4 figures. Submitted to Phys. Rev. Let
Differential Production Cross Section of Z Bosons as a Function of Transverse Momentum at sqrt{s}=1.8 TeV
We present a measurement of the transverse momentum distribution of Z bosons
produced in ppbar collisions at sqrt{s}=1.8 TeV using data collected by the D0
experiment at the Fermilab Tevatron Collider during 1994--1996. We find good
agreement between our data and a current resummation calculation. We also use
our data to extract values of the non-perturbative parameters for a particular
version of the resummation formalism, obtaining significantly more precise
values than previous determinations.Comment: 10 pages, 2 figures, submitted to Phys. Rev. Letters v2 has margin
error correcte
Spin Correlation in tt-bar Production from pp-bar Collisions at sqrt(s)=1.8 TeV
The D0 collaboration has performed a study of spin correlation in tt-bar
production for the process tt-bar to bb-bar W^+W^-, where the W bosons decay to
e-nu or mu-nu. A sample of six events was collected during an exposure of the
D0 detector to an integrated luminosity of approximately 125 pb^-1 of
sqrt{s}=1.8 TeV pp-bar collisions. The standard model (SM) predicts that the
short lifetime of the top quark ensures the transmission of any spin
information at production to the tt-bar decay products.
The degree of spin correlation is characterized by a correlation coefficient
k. We find that k>-0.25 at the 68% confidence level, in agreement with the SM
prediction of k=0.88.Comment: Submitted to PRL, Added references, minor changes to tex
Search for Large Extra Dimensions in Dielectron and Diphoton Production
We report a search for effects of large extra spatial dimensions in ppbar
collisions at a center-of-mass energy of 1.8 TeV with the DZero detector, using
events containing a pair of electrons or photons. The data are in good
agreement with the expected background and do not exhibit evidence for large
extra dimensions. We set the most restrictive lower limits to date, at the 95%
confidence level, on the effective Planck scale between 1.0 TeV and 1.4 TeV for
several formalisms and numbers of extra dimensions.Comment: 6 pages, 2 figures, submitted to Phys. Rev. Let
Search for Charged Higgs Bosons in Decays of Top Quark Pairs
We present a search for charged Higgs bosons in decays of pair-produced top
quarks using 109.2 +- 5.8 pb^-1 of data recorded from ppbar collisions at
sqrt{s} = 1.8 TeV by the D0 detector during 1992-96 at the Fermilab Tevatron.
No evidence is found for charged Higgs production, and most parts of the
[m(H+),tan(beta)] parameter space where the decay t -> bH+ has a branching
fraction close to or larger than that for t -> bW+ are excluded at 95%
confidence level. Assuming m(t) = 175 GeV and sigma(ppbar -> ttbar) = 5.5 pb,
for m(H+) = 60 GeV, we exclude tan(beta) 40.9.Comment: 11 pages, 3 figures, submitted to PR
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