DA ESCUTA À ESCRITA: o fazer policial na construção de sujeitos e crimes em inquéritos policiais de violência contra a mulher

Through the analysis of police inquiries of domestic violence and through the participant observation of a Women's Defense Police Station, I sought to investigate how the discourse and moralities that are present in the police station dispute the categories of victim, perpetrator and violence, informing the framing of facts in legal narratives and leaving marks in the criminal process.A través del análisis de investigaciones policiales de violencia doméstica y de la observación participante de una Comisaría de Defensa de la Mujer, se buscó investigar cómo discursividades y moralidades en el espacio policial disputan las categorías de víctima, autor y violencia, informando el encuadramiento de hechos en narrativas legales y dejando marcas en el proceso penal.Através da análise de inquéritos policiais de violência doméstica e da observação participante de uma Delegacia de Defesa da Mulher, buscou-se investigar como as discursividades e moralidades presentes no espaço policial disputam as categorias de vítima, autor e violência, informando o enquadramento de fatos e narrativas legais e deixando marcas no processo penal

Incarcerating at any cost: drug trafficking and imprisonment in Brazilian court reasoning

Brazil has the third largest prison population worldwide—over 700,000 people. At least 28% of them are in prison for drug trafficking. Given that situation, this paper explores the conflicts among the law; the Supremo Tribunal Federal, or Brazilian Federal Supreme Court (STF) and lower court precedents. Based on a qualitative and quantitative study of Tribunal de Justiça de São Paulo, or São Paulo State Supreme Court (TJSP) and Superior Tribunal de Justiça, or Brazilian Superior Court of Justice (STJ) decisions between 2017 and 2018, this paper focuses on the arguments put forward by those courts to prevent the imposition of non-custodial sanctions on people convicted of drug trafficking even though they may be first-time offenders with no criminal record. Our research shows the main arguments used are related to the amount, type and variety of seized drugs; the convict’s criminal history; the person’s employment status at the time of arrest and the insufficiency of non-custodial sentences in cases of drug trafficking. Our conclusion is that the reasoning behind convictions for drug trafficking favors imprisonment even in situations in which the law and the STF precedents would allow non-custodial sentences

Design and characterization of an antiproton deceleration beamline for the PUMA experiment

We report on the design and characterization of an antiproton deceleration beamline, based on a pulsed drift tube, for the PUMA experiment at the Antimatter Factory at CERN. The design has been tailored to high-voltage (100kV) and ultra-high vacuum (below 10−10mbar) conditions. A first operation achieved decelerating antiprotons from an initial energy of 100keV down to (3898±3)eV, marking the initial stage in trapping antiprotons for the PUMA experiment. Employing a high-voltage ramping scheme, the pressure remains below 2×10−10mbar upstream of the pulsed drift tube for 75% of the cycle time. The beamline reached a transmission of (55±3)% for antiprotons decelerated to 4keV. The beam is focused on a position sensitive detector to a spot with horizontal and vertical standard deviations of σhoriz=(3.0±0.1)mm and σvert=(3.8±0.2)mm, respectively. This spot size is within the acceptance of the PUMA Penning trap.We report on the design and characterization of an antiproton deceleration beamline, based on a pulsed drift tube, for the PUMA experiment at the Antimatter Factory at CERN. The design has been tailored to high-voltage (100 kV) and ultra-high vacuum (below $10^{-10}$ mbar) conditions. A first operation achieved decelerating antiprotons from an initial energy of 100 keV down to ($3898\pm 3$) eV, marking the initial stage in trapping antiprotons for the PUMA experiment. Employing a high-voltage ramping scheme, the pressure remains below $2\cdot 10^{-10}$ mbar upstream of the pulsed drift tube for 75% of the cycle time. The beamline reached a transmission of ($55 \pm 3$)% for antiprotons decelerated to 4 keV. The beam is focused on a position sensitive detector to a spot with horizontal and vertical standard deviations of ${\sigma}_\mathrm{horiz}$ = ($3.0 \pm 0.1$) mm and ${\sigma}_\mathrm{vert}$ = ($3.8 \pm 0.2$) mm, respectively. This spot size is within the acceptance of the PUMA Penning trap

Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

Abstract Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics data set for 32 patients across 25 tumor types for proteogenomic-based discovery of neoantigens. By using an optimized computational approach, we discover a large number of tumor-specific and tumor-associated antigens. To create a pipeline for the identification of neoantigens in our cohort, we combine DNA and RNA sequencing with MS-based immunopeptidomics of tumor specimens, followed by the assessment of their immunogenicity and an in-depth validation process. We detect a broad variety of non-canonical HLA-binding peptides in the majority of patients demonstrating partially immunogenicity. Our validation process allows for the selection of 32 potential neoantigen candidates. The majority of neoantigen candidates originates from variants identified in the RNA data set, illustrating the relevance of RNA as a still understudied source of cancer antigens. This study underlines the importance of RNA-centered variant detection for the identification of shared biomarkers and potentially relevant neoantigen candidates