467 research outputs found
Disposable Hand-Held Device for Collection of Exhaled Breath Condensate
A breath condensate collection apparatus comprising a central chamber, a breath input assembly, a plunger assembly and a breath condensate collection port. The central chamber has inner and outer side walls with a coolant material sealed in between. The breath input assembly is disposed on the side of the central chamber in fluid communication with the chamber interior. The plunger assembly has a piston, slidably
disposed in the chamber, and a handle extending from a first end of the chamber. The collection port is disposed at the second end of the central chamber in fluid communication with the interior of the chamber. Obstructive structures may be arranged in the chamber interior for increasing the surface area on which condensate may form. The apparatus may also include an outlet assembly that may be removed and replaced with a sampling well into which the condensate may be washed with a buffer solution
Method and System for Diagnosing Post-Surgical Pulmonary Vascular Occlusions
A method of determining the presence of pulmonary embolism is a postoperative patient using the carbox ratio of the patient prior to the surgical procedure and the carbox ratio of
the patient after to the surgical procedure. The characteristics of the breath of the patient are obtained prior to a surgical procedure for a baseline and then afterwards if the patient has difficult breathing. The mean carbox ratios from the baseline and post-surgical data collections are then compared to noninvasively predict the likelihood that the patient has developed pulmonary embolism. A decrease in the carbox ratio of more than twenty-five percent (25%) represents an abnormal test and is consistent with possible pulmonary embolism. No change or an increase in the carbox ratio suggests the absence of pulmonary embolism
NON-INVASIVE DEVICE AND METHOD FOR MEASURING THE CARDIAC OUTPUT OF A PATIENT
A method and system for detecting the presence of restriction to expired airflow in humans or animals by analyzing the expired capnogram and oxygram, as well as the geometric analysis of the real-time plot of the waveform that depicts the instantaneous ratio of CO2 to O2 (the carboxygram ratio). Airway obstructions causes an increase in the Q-angle between the slope of phase 11 and slope of phase III in the expired carboxygram. The diagnostic accuracy of the detection of airways obstruction is further enhanced by measuring the ratio of time spent in exhalation (Te) versus inhalation (Ti). The system uses the combination of an increased carboxygram Q-angle, and a prolonged Te/Ti to detect presence of airways obstruction
NON-INVASIVE DEVICE AND METHOD FOR THE DIAGNOSIS OF PULMONARY VASCULAR OCCLUSIONS
The invention involves a device and method for ascertaining the functioning of the respiratory system and determining whether a pulmonary embolism is present. The device comprises an apparatus containing sensors which measure the amount of a particular gas expired from a patient's lungs, including a non-ambient gas which is previously provided to the patent. From this data, a processor computes the concentration of expired gas as a function of expired volume and displays the results on a screen. By comparing the results to predetermined values from afflicted and healthy patient populations, an accurate determination can be made regarding the presence of a pulmonary embolism
SYSTEM AND METHOD FOR DETERMINING AIRWAY OBSTRUCTION
A method and system for detecting the presence of restriction to expired airflow in humans or animals by analyzing the expired capnogram and oxygram, as well as the geometric analysis of the real-time plot of the waveform that depicts the instantaneous ratio of CO2 to O2 (the carboxygram ratio). Airway obstructions causes an increase in the Q-angle between the slope of phase 11 and slope of phase III in the expired carboxygram. The diagnostic accuracy of the detection of airways obstruction is further enhanced by measuring the ratio of time spent in exhalation (Te) versus inhalation (Ti). The system uses the combination of an increased carboxygram Q-angle, and a prolonged Te/Ti to detect presence of airways obstruction
Device and Method for Collection of Exhaled Alveolar Breath Condensate
A diagnosis method for respiratory disease based on the separation of the expired airway phase in an exhaled breath from the alveolar phase, and a device to accomplish the method. The device includes a cartridge assembly and a disposable condensing chamber carried in a substantially enclosed housing. The cartridge assembly includes a disposable
cartridge and a reusable control system that monitors a characteristic of gas passing through the cartridge to determine when to divert the exhaled breath to an exhaust outlet and when to divert the exhaled breath to the condensing chamber. The characteristic is selected as being representative of the transition from the expired airway phase to the alveolar phase. Also included are a refrigeration system, an auxiliary monitoring system for determining when a sufficient volume of gas has been produced, and a built-in analyzer
SYSTEM AND METHOD FOR DETERMINING THE DEGREE OF ABNORMALITY OF A PATIENT'S VITAL SIGNS
A system and method for determining the degree of abnormality of a vital sign of a patient by obtaining the clinical profile of said patient and determining the statistical difference between the vital sign of the patient and the vital signs of previously evaluated patients having similar clinical profiles. The vital signs of previously evaluated patients having similar clinical profiles are determined based on matching the attributes of the patent's clinical profile to the clinical profiles of previously evaluated patients. The statistical difference, and the patent's clinical profile may be exported to an electronic medical record system or printed in hard copy for inclusion in the patient's medial file
Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome
BACKGROUND: Pulmonary thromboembolism (PTE) is a common diagnosis and a leading cause of cardiovascular morbidity and mortality. A growing literature has associated PE with systemic inflammation, and global hyper-coagulability, which contribute to lung remodeling and clot recurrence. The source and mechanism of inflammation remains unstudied. In humans, inhibition of cholesterol synthesis with statins decreases biomarkers of inflammation. We test the differential effect of pulmonary vascular occlusion during mild and severe pulmonary embolism on the lung transcriptome.
METHODS: Experimental PE was induced in adult male rats by injection of 25 micron polystyrene microspheres into the jugular vein. The effect of Mild PE, (2-h right ventricular systolic pressure [RVSP] normal, 18-h RVSP 44 mmHg) and Severe PE (2-h RVSPβ>β50 mmHg; 18-h RVSP 44 mmHg) on lungs was assessed by measuring transcriptome-wide changes in gene expression by DNA microarrays.
RESULTS: Severe PE was associated with a large change in lung gene expression and in the expression of KEGG pathways and other gene functional annotation groups. Mild PE was also associated with a large number of significant changes in gene expression and in the expression of KEGG pathways and gene functional annotation groups, even after only 2 h of PE. Up-regulated pathways included increased adipocytokine, chemokine and cytokine signaling as well as cholesterol synthesis.
CONCLUSIONS: Mild PE without acute pulmonary hypertension (PH) increased lung gene expression of inflammatory pathways, including increased cholesterol synthesis. These data indicate that even mild persistent pulmonary vascular occlusion is capable of inciting an inflammatory response from the lung. These data imply the detrimental effect of unresolved pulmonary obstruction from PE
USE OF FREE HEMOGLOBIN AND ITS SURROGATE MARKERS TO DETECT AND MONITOR PULMONARY HYPERTENSION
A method for diagnosing and monitoring pulmonary hypertension using free hemoglobin, as well as surrogates for free hemoglobin, as markers for pulmonary hypertension. Bodily fluids, such as blood, serum, plasma, urine and/or breathe condensate may be collected and analyzed to determine the concentration of free hemoglobin or surrogates of free hemoglobin. The concentration indicates the presence or absence of pulmonary hypertension
Method of Using Carbonic Anhydrase to Detect Hemolysis
A method and a test for using carbonic anhydrase (CA), particularly CA-I or CA-II, as a biomarker ofhemolysis. The method and test detect hemolysis by determining a percentage erythrocyte hemolysis in a specimen or sample of blood based upon quantification of carbonic anhydrase present in the extracellular portion of the blood. The method and test serve to optimize therapeutic efficacy for treatments of hemolysis. Plasma carbonic anhydrase is used to determine the percentage hemolysis in plasma. Furthermore, CA is quantified with specificity to the isozyme present in the plasma
- β¦