1,044 research outputs found
Structure factor of thin films near continuous phase transitions
The two-point correlation function in thin films is studied near the critical
point of the corresponding bulk system. Based on fieldtheoretic renormalization
group theory the dependences of this correlation function on the lateral
momentum, the two distances normal to the free surfaces, temperature, and film
thickness are determined. The corresponding scattering cross section of X-rays
and neutrons under grazing incidence is calculated. It reveals the various
singularities of the two-point correlation function.Comment: 61 pages, 14 figures, submitted to PR
Local functional models of critical correlations in thin-films
Recent work on local functional theories of critical inhomogeneous fluids and
Ising-like magnets has shown them to be a potentially exact, or near exact,
description of universal finite-size effects associated with the excess
free-energy and scaling of one-point functions in critical thin films. This
approach is extended to predict the two-point correlation function G in
critical thin-films with symmetric surface fields in arbitrary dimension d. In
d=2 we show there is exact agreement with the predictions of conformal
invariance for the complete spectrum of correlation lengths as well as the
detailed position dependence of the asymptotic decay of G. In d=3 and d>=4 we
present new numerical predictions for the universal finite-size correlation
length and scaling functions determining the structure of G across the
thin-film. Highly accurate analytical closed form expressions for these
universal properties are derived in arbitrary dimension.Comment: 4 pages, 1 postscript figure. Submitted to Phys Rev Let
Polymer depletion interaction between two parallel repulsive walls
The depletion interaction between two parallel repulsive walls confining a
dilute solution of long and flexible polymer chains is studied by
field-theoretic methods. Special attention is paid to self-avoidance between
chain monomers relevant for polymers in a good solvent. Our direct approach
avoids the mapping of the actual polymer chains on effective hard or soft
spheres. We compare our results with recent Monte Carlo simulations [A. Milchev
and K. Binder, Eur. Phys. J. B 3, 477 (1998)] and with experimental results for
the depletion interaction between a spherical colloidal particle and a planar
wall in a dilute solution of nonionic polymers [D. Rudhardt, C. Bechinger, and
P. Leiderer, Phys. Rev. Lett. 81, 1330 (1998)].Comment: 17 pages, 3 figures. Final version as publishe
Adaptive Radiation within Marine Anisakid Nematodes: A Zoogeographical Modeling of Cosmopolitan, Zoonotic Parasites
Parasites of the nematode genus Anisakis are associated with aquatic organisms. They can be found in a variety of marine hosts including whales, crustaceans, fish and cephalopods and are known to be the cause of the zoonotic disease anisakiasis, a painful inflammation of the gastro-intestinal tract caused by the accidental consumptions of infectious larvae raw or semi-raw fishery products. Since the demand on fish as dietary protein source and the export rates of seafood products in general is rapidly increasing worldwide, the knowledge about the distribution of potential foodborne human pathogens in seafood is of major significance for human health. Studies have provided evidence that a few Anisakis species can cause clinical symptoms in humans. The aim of our study was to interpolate the species range for every described Anisakis species on the basis of the existing occurrence data. We used sequence data of 373 Anisakis larvae from 30 different hosts worldwide and previously published molecular data (n = 584) from 53 field-specific publications to model the species range of Anisakis spp., using a interpolation method that combines aspects of the alpha hull interpolation algorithm as well as the conditional interpolation approach. The results of our approach strongly indicate the existence of species-specific distribution patterns of Anisakis spp. within different climate zones and oceans that are in principle congruent with those of their respective final hosts. Our results support preceding studies that propose anisakid nematodes as useful biological indicators for their final host distribution and abundance as they closely follow the trophic relationships among their successive hosts. The modeling might although be helpful for predicting the likelihood of infection in order to reduce the risk of anisakiasis cases in a given area
Quantum Quenches in Extended Systems
We study in general the time-evolution of correlation functions in a extended
quantum system after the quench of a parameter in the hamiltonian. We show that
correlation functions in d dimensions can be extracted using methods of
boundary critical phenomena in d+1 dimensions. For d=1 this allows to use the
powerful tools of conformal field theory in the case of critical evolution.
Several results are obtained in generic dimension in the gaussian (mean-field)
approximation. These predictions are checked against the real-time evolution of
some solvable models that allows also to understand which features are valid
beyond the critical evolution.
All our findings may be explained in terms of a picture generally valid,
whereby quasiparticles, entangled over regions of the order of the correlation
length in the initial state, then propagate with a finite speed through the
system. Furthermore we show that the long-time results can be interpreted in
terms of a generalized Gibbs ensemble. We discuss some open questions and
possible future developments.Comment: 24 Pages, 4 figure
Comparative Antimicrobial Activity of Granulysin against Bacterial Biothreat Agents
Granulysin is a cationic protein produced by human T cells and natural killer cells that can kill bacterial pathogens through disruption of microbial membrane integrity. Herein we demonstrate antimicrobial activity of the granulysin peptide derived from the active site against Bacillus anthracis, Yersinia pestis, Francisella tularensis, and Burkholderia mallei, and show pathogen-specific differences in granulysin peptide effects. The susceptibility of Y. pestis to granulysin is temperature dependent, being less susceptible when grown at the flea arthropod vector temperature (26°C) than when grown at human body temperature. These studies suggest that augmentation of granulysin expression by cytotoxic lymphocytes, or therapeutic application of granulysin peptides, could constitute important strategies for protection against select agent bacterial pathogens. Investigations of the microbial surface molecules that determine susceptibility to granulysin may identify important mechanisms that contribute to pathogenesis
Critical dynamics in thin films
Critical dynamics in film geometry is analyzed within the field-theoretical
approach. In particular we consider the case of purely relaxational dynamics
(Model A) and Dirichlet boundary conditions, corresponding to the so-called
ordinary surface universality class on both confining boundaries. The general
scaling properties for the linear response and correlation functions and for
dynamic Casimir forces are discussed. Within the Gaussian approximation we
determine the analytic expressions for the associated universal scaling
functions and study quantitatively in detail their qualitative features as well
as their various limiting behaviors close to the bulk critical point. In
addition we consider the effects of time-dependent fields on the
fluctuation-induced dynamic Casimir force and determine analytically the
corresponding universal scaling functions and their asymptotic behaviors for
two specific instances of instantaneous perturbations. The universal aspects of
nonlinear relaxation from an initially ordered state are also discussed
emphasizing the different crossovers that occur during this evolution. The
model considered is relevant to the critical dynamics of actual uniaxial
ferromagnetic films with symmetry-preserving conditions at the confining
surfaces and for Monte Carlo simulations of spin system with Glauber dynamics
and free boundary conditions.Comment: 64 pages, 21 figure
Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis
Successful treatment of inhalation anthrax, pneumonic plague and tularemia can be achieved with fluoroquinolone antibiotics, such as ciprofloxacin and levofloxacin, and initiation of treatment is most effective when administered as soon as possible following exposure. Bacillus anthracis Ames, Yersinia pestis CO92, and Francisella tularensis SCHU S4 have equivalent susceptibility in vitro to ciprofloxacin and levofloxacin (minimal inhibitory concentration is 0.03 μg/ml); however, limited information is available regarding in vivo susceptibility of these infectious agents to the fluoroquinolone antibiotics in small animal models. Mice, guinea pig, and rabbit models have been developed to evaluate the protective efficacy of antibiotic therapy against these life-threatening infections. Our results indicated that doses of ciprofloxacin and levofloxacin required to protect mice against inhalation anthrax were approximately 18-fold higher than the doses of levofloxacin required to protect against pneumonic plague and tularemia. Further, the critical period following aerosol exposure of mice to either B. anthracis spores or Y. pestis was 24 h, while mice challenged with F. tularensis could be effectively protected when treatment was delayed for as long as 72 h postchallenge. In addition, it was apparent that prolonged antibiotic treatment was important in the effective treatment of inhalation anthrax in mice, but short-term treatment of mice with pneumonic plague or tularemia infections were usually successful. These results provide effective antibiotic dosages in mice, guinea pigs, and rabbits and lay the foundation for the development and evaluation of combinational treatment modalities
Development of a cell-based fluorescence resonance energy transfer reporter for Bacillus anthracis lethal factor protease
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