Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids

The series of monomethyne cyanine dyes as possible fluorescent probes for DNA and RNA analysis were synthesized and their optical properties were studied. Two dyes interacted with native DNA and RNA with strong fluorescence enhancement (up to 350 and 1550 times for Cyan 3 and Cyan 6, respectively). The complex of Cyan 4 with nucleic acids had extremely large Stokes shift (154 nm). Methylenoxybenzthiazole residue seems to be perspective structural fragment for the synthesis of new nucleic acid binding cyanine dyes.Досліджено спектральні характеристики семи синтезованих монометинових ціанінів як мож­ливих флюоресцентних зондів, специфічних до нуклеїнових кислот (НК). Два барвники Cyan 3 та Cyan 6 у комплексі з НК значно підвищували власнуфлюоресценцію (у 160 i 800 разів з ДНК та в 350 і 1550 разів з РНК відповідно). Cyan 4 при взаємодії з НК показав аномально великий (154 нм) Стоксів зсув. Метиленоксибензтіазоловий структурний фрагмент виявив перспективні вла­ стивості для конструювання нових НК-специфічних барвників серед досліджених ціанінів.Исследованы спектральные характеристики семи синтезированных монометиновых цианинов как возможных флюоресцентных зондов, специфичных к нуклеиновым кислотам (HК). Два кра­сителя Cyan 3 и Cyan 6 в комплексе с НК значительно повышали собственную флюоресценцию ( в 160 и 800 раз с ДНК и в 350 и 1550 раз с РНК соответственно). Cyan 4 при взаимодействии с НК показал аномально больиіой (154 нм) Стоксов сдвиг. Метиленоксибензтиазоловый структурный фрагмент проявил перспективные свойства для конструирования новых НК-специфических красителей среди исследованных цианинов

High Precision Mass Measurements in Ψ\Psi and Υ\Upsilon Families Revisited

High precision mass measurements in $\Psi$ and $\Upsilon$ families performed in 1980-1984 at the VEPP-4 collider with OLYA and MD-1 detectors are revisited. The corrections for the new value of the electron mass are presented. The effect of the updated radiative corrections has been calculated for the $J/\Psi(1S)$ and $\Psi(2S)$ mass measurements.Comment: 5 pages, 1 table, submitted to Phys. Lett.

(Borel) convergence of the variationally improved mass expansion and the O(N) Gross-Neveu model mass gap

We reconsider in some detail a construction allowing (Borel) convergence of an alternative perturbative expansion, for specific physical quantities of asymptotically free models. The usual perturbative expansions (with an explicit mass dependence) are transmuted into expansions in 1/F, where $F \sim 1/g(m)$ for $m \gg \Lambda$ while $F \sim (m/\Lambda)^\alpha$ for m \lsim \Lambda, $\Lambda$ being the basic scale and $\alpha$ given by renormalization group coefficients. (Borel) convergence holds in a range of $F$ which corresponds to reach unambiguously the strong coupling infrared regime near $m\to 0$, which can define certain "non-perturbative" quantities, such as the mass gap, from a resummation of this alternative expansion. Convergence properties can be further improved, when combined with $\delta$ expansion (variationally improved perturbation) methods. We illustrate these results by re-evaluating, from purely perturbative informations, the O(N) Gross-Neveu model mass gap, known for arbitrary $N$ from exact S matrix results. Comparing different levels of approximations that can be defined within our framework, we find reasonable agreement with the exact result.Comment: 33 pp., RevTeX4, 6 eps figures. Minor typos, notation and wording corrections, 2 references added. To appear in Phys. Rev.

The “Moscow as the third Rome” concept: Its Nature and Interpretations since the 19th to Early 21st Centuries

The authors seek to identify the main specific features of the “Moscow as the Third Rome” concept (Philotheus) and its later interpretations, geopolitical as well, in modern Russia. The historical and interdisciplinary research conducted based on the source made it possible to propose a new vision of possible grounds for Russian foreign policy strategy. The “Third Rome” notion, from the perspective of its impact on Russian foreign policy and its geopolitical dimension, has been addressed in the works of many authors. It conveys both a historiosophic phenomenon, a national idea and the vision of a fair state. The concept, being in tune with the mood of Russian society, has had an impact on both the inner structure of the state and its foreign policy, which allows us to suggest that the concept of Moscow as the Third Rome may be considered Russia’s informal geopolitical doctrine. © 2018 Universidad Complutense de Madrid. All rights reserved

Modern requirements to the formation of professional competence of neonatologists in residency

The article deals with the problems of training physicians in pediatrics, namely neonatology, in terms of reforms according to the Law of Ukraine “On Higher Education” entered into force in 2014, and the introduction of the new form of specialists’ training — residency

Selenium in ischemic stroke

Selenium plays a significant role in brain physiology, whereas data on the role of selenium in stroke pathophysiology are inconsistent. The objective of this chapter is to review current findings on the role of selenium in ischemic stroke. The existing human data demonstrate that stroke is associated with significantly reduced Se levels as well as glutathione peroxidase activity. Oppositely, we have revealed significantly higher serum Se levels in stroke, being inversely associated with brain damage markers. However, Se supplementation trials in stroke patients provided inconsistent results. Experimental studies provided a significant contribution to potential neuroprotective effects in stroke. Se supplementation was shown to increase antioxidant enzyme activity, thus reducing reactive oxygen species (ROS) production and macromolecule oxidative damage. Se-induced prevention of mitochondrial dysfunction may also significantly contribute to reduced ROS production and restoration of ATP levels. Se exposure was also shown to prevent NF-kB and AP-1 activation, thus reducing proinflammatory cytokine production and leukocyte infiltration. Reduce caspase 3 activation and apoptosis, as well as decreased autophagy, were observed under ischemic conditions in Se-treated animals. Se may also reduce adhesion molecule expression, as well as glutamate excitotoxicity, although these effects were not demonstrated in stroke models. The existing data demonstrate the neuroprotective potential of selenium in ischemic stroke. However, the majority of indications of the neuroprotective effect of selenium arise from experimental studies, whereas human data remain insufficient. Further clinical studies and especially placebo-controlled trials are strongly required to highlight the potential effects of selenium supplements in ischemic stroke management. © Springer International Publishing AG, part of Springer Nature 2018

Control and management placing of objects

В статье рассмотрены вопросы реализации и применения новой технологии Adobe AIR в организации учета и отображения автомашин на стоянке. Использование механизма Flash, который встроен в среду AIR, дает возможность создавать удобные, информативные и гибкие интерфейсы для приложений, что было бы затруднительно при написании таких приложений на языке C++. Программный интерфейс реализован в виде однооконной прикладной программы, которая содержит элементы управления для выполнения непосредственных команд управления и размещением.У статті розглянуті питання реалізації і застосування нової технології Adobe AIR в організації обліку і відображення автомашин на стоянці. Використання механізму Flash, який вбудований в середу AIR, дає можливість створювати зручні, інформативні і гнучкі інтерфейси для додатків, що було б важко при написанні таких додатків на мові C++. Програмний інтерфейс реалізований у вигляді одновіконної прикладної програми, яка містить елементи управління для виконання безпосередніх команд управління і розміщенням.In the article the questions of realization and application of new technology of Adobe AIR are considered in organization of account and reflection of cars on a stand. The use of mechanism of Flash, which is built-in on Wednesday AIR, enables to create comfortable, informing and flexible interfaces for appendixes, that would be difficult at writing of such appendixes in language of C++. A programmatic interface is realized as a one-window application program which contains custom for implementation of direct commands of management controls and placing

Cardiac Arrhythmia: Atrial Flutter in a Newborn. Case Study

The article gives case report of rare in neonatal period cardiac arrhythmia — atrial flutter. The disease is one of the manifestations of life-threatening heart rhythm disorders, has no characteristic clinical picture, is diagnosed only by means of an electrocardiogram