Direct comparison between potential landscape and local density of states in a disordered two-dimensional electron system

The local density of states (LDOS) of the adsorbate induced two-dimensional electron system (2DES) on n-InAs(110) is studied by low-temperature scanning tunneling spectroscopy. The LDOS exhibits irregular structures with fluctuation lengths decreasing with increasing energy. Fourier transformation reveals that the k-values of the unperturbed 2DES dominate the LDOS, but additional lower k-values contribute significantly. To clarify the origin of the additional k-space intensity, we measure the potential landscape of the same 2DES area with the help of the tip induced quantum dot. This allows to calculate the expected LDOS from the single particle Schroedinger equation and to directly compare it with the measured one. Reasonable correspondance between calculated and measured LDOS is found.Comment: 7 pages, 4 figures, submitted to PR

Long-term strategies for flood risk management: scenario definition and strategic alternative design

This report reviews some mainstream existing methods of scenario development and use, as well as experiences with the design and assessment of strategic alternatives for flood risk management. Next, a procedure and methods are proposed and discussed. Thirdly, the procedure and methods are tried on the Schelde Estuary and the Thames Estuary and, finally, conclusions are draw

A Letter of Hendrik G. Klijn and K. Van De Bosch to the Christelijke Afgescheidenen in Nederland

A letter of Hendrik G. Klijn and K. van de Bosch to the Christelijke Afgescheidenen in Nederland shortly after these two Reformed Church in America ministers separated themselves along with their congregations from the Reformed Church in America and leading to the formation of the Christian Reformed Church.https://digitalcommons.hope.edu/vrp_1850s/1371/thumbnail.jp

DBFM(O)contracten in de publieke infrastrcutuur in Nederland en Belgie

Op 22 november 2016 vond er in Antwerpen aan de Universiteit van Antwerpen een internationaal wetenschappelijk congres plaats over publiek-private samenwerking. In haar rol als facilitator en kennisontwikkelaar nam het Kenniscentrum PPS van de Vlaamse overheid (Vlaams Kenniscentrum PPS) haar rol op om samen met de organiserende partners van het congres in de schoot van dit congres een conferentie op te zetten waar PPS-beoefenaars en wetenschappers met elkaar in dialoog konden gaan. Deze dialoog kreeg verder vorm door een samenwerking tussen verschillende universiteiten, en door de ondersteuning van diverse overheden en bedrijven in Vlaanderen en Nederland. In die zin was het zelf ook een vorm van publiek-private samenwerking. In deze publicatie blikken we terug op dit succesvolle seminarie en laten we u proeven van de talrijke interessante reflecties als stof tot nadenken. De organisatoren van het congres en de editors van deze publicatie hopen dat de teksten het debat over PPS kunnen voeden, en dat het werk een bijdrage kan leveren tot een verdere professionalisering en tot innovaties in de PPS-praktijk en het onderzoek van morgen

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data

Background: Most approaches used to find recurrent or differential DNA Copy Number Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of tumour samples depend on the discretization of the aCGH data to gain, loss or no-change states. This causes loss of valuable biological information in tumour samples, which are frequently heterogeneous. We have previously developed an algorithm, KC-SMART, that bases its estimate of the magnitude of the CNA at a given genomic location on kernel convolution (Klijn et al., 2008). This accounts for the intensity of the probe signal, its local genomic environment and the signal distribution across multiple samples. Results: Here we extend the approach to allow comparative analyses of two groups of samples and introduce the R implementation of these two approaches. The comparative module allows for a supervised analysis to be performed, to enable the identification of regions that are differentially aberrated between two user-defined classes. We analyzed data from a series of B- and T-cell lymphomas and were able to retrieve all positive control regions (VDJ regions) in addition to a number of new regions. A t-test employing segmented data, that we implemented, was also able to locate all the positive control regions and a number of new regions but these regions were highly fragmented. Conclusions: KC-SMARTR offers recurrent CNA and class specific CNA detection, at different genomic scales, in a single package without the need for additional segmentation. It is memory efficient and runs on a wide range of machines. Most importantly, it does not rely on data discretization and therefore maximally exploits the biological information in the aCGH data.MediamaticsElectrical Engineering, Mathematics and Computer Scienc

Dietary supplementation with multiple micronutrients: No beneficial effects in pediatric cystic fibrosis patients

AbstractBackgroundCystic fibrosis (CF) patients are subjected to increased oxidative stress due to chronic pulmonary inflammation and recurrent infections. Additionally, these patients have diminished skeletal muscle performance and exercise capacity. We hypothesize that a mixture of multiple micronutrients could have beneficial effects on pulmonary function and muscle performance.MethodsA double-blind, randomized, placebo controlled, cross-over trial with a mixture of multiple micronutrients (ML1) was performed in 22 CF patients (12.9±2.5 yrs) with predominantly mild lung disease. Anthropometric measures, pulmonary function, exercise performance by bicycle ergometry, muscular strength and vitamins A and E were determined.ResultsAnalysis was performed using the paired Student t-test comparing the change in each parameter during ML1 and placebo. Plasma vitamin E and A levels increased during ML1 when compared to placebo. However, no significant difference between the effect of the ML1 or placebo was observed neither for FEV1, FVC, anthropometry, nor for the parameters for muscle performance.ConclusionsThe micronutrient mixture was not superior to placebo with respect to changes in pulmonary function or muscle performance in pediatric CF patients, despite a significant increase in plasma vitamin E concentrations