Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model

The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic stem cell transplantation. We examined the efficacy of post transplant administration of a specific CXCR4 antagonist (AMD3100) in improving animal survival and in enhancing donor hematopoietic cell engraftment using a congeneic mouse transplantation model. AMD3100 was administered subcutaneously at 5 mg/kg body weight 3 times a week beginning at day +2 post-transplant. Post-transplant administration of AMD3100 significantly improves animal survival. AMD3100 reduces pro-inflammatory cytokine/chemokine production. Furthermore, post transplant administration of AMD3100 selectively enhances donor cell engraftment and promotes recovery of all donor cell lineages (myeloid cells, T and B lymphocytes, erythrocytes and platelets). This enhancement results from a combined effect of increased marrow niche availability and greater cell division induced by AMD3100. Our studies shed new lights into the biological roles of SDF-1/CXCR4 interaction in hematopoietic stem cell engraftment following transplantation and in transplant-related mortality. Our results indicate that AMD3100 provides a novel approach for enhancing hematological recovery following transplantation, and will likely benefit patients undergoing transplantation

Selective oxidation of CO in hydrogen-rich mixtures and kinetics investigation on platinum-gold supported on zinc oxide catalyst

10.1007/s11433-006-2011-1Journal of Power Sources1552440-446JPSO

Gender, politics and sugarcane commercialisation in Tanzania

This article explores relationships between state, corporate capital and local stakeholders in the political economy of sugarcane from a gender perspective. The findings, based on empirical research at the site of Tanzania’s largest sugarcane producer pre- and post-privatisation, provide insights into the degree to which the estate-outgrower model can be regarded as ‘inclusive’ for women and men. Three aspects of commercial sugarcane production are analysed: land tenure, labour and leadership within canegrowers’ associations. We argue that politico-economic changes in the sector post-privatisation have increased gender differentiation in sugarcane production and consolidated power in the hands of local elites