1,329 research outputs found
Eugenie S. Kleinerman, MD
https://openworks.mdanderson.org/legendsandlegacieschapters/1009/thumbnail.jp
10: Eugenie S. Kleinerman, MD
https://openworks.mdanderson.org/legendsandlegaciesbook/1012/thumbnail.jp
We should see certain things yet, let us hope and believe : Technology, Sex, and Politics in Mark Twain\u27s \u3cem\u3eConnecticut Yankee\u3c/em\u3e
Through his modern Yankee, Mark Twain reveals to his readers the underlying desire to overcome the very material world he seems to want to instantiate. Although the Yankee seems a modern man who simply wants to create the conditions in Arthurian England by which his body will be most comfortable, both his zeal for this project and the trajectory of his soul\u27s course during the book betray an underlying hope to overcome his mortal coil through first technological and then political projects. In charting the impetus and evolution of the Yankee\u27s psychology for us, Twain teaches us much about the nature of the modern project --its underlying hopes and its potential for dangerous, even totalitarian, excesses. As appealing as the starkly contrasting Arthurians might be, given this insight, Twain does not ultimately endorse this position but shows that its explicit claim does not ultimately satisfy our desire for noninstrumental goods
Epigenetic Regulation of Apoptosis and Cell Cycle in Osteosarcoma
The role of genetic mutations in the development of osteosarcoma, such as alterations in p53 and Rb, is well understood. However, the significance of epigenetic mechanisms in the progression of osteosarcoma remains unclear and is increasingly being investigated. Recent evidence suggests that epigenetic alterations such as methylation and histone modifications of genes involved in cell cycle regulation and apoptosis may contribute to the pathogenesis of this tumor. Importantly, understanding the molecular mechanisms of regulation of these pathways may give insight into novel therapeutic strategies for patients with osteosarcoma. This paper serves to summarize the described epigenetic mechanisms in the tumorigenesis of osteosarcoma, specifically those pertaining to apoptosis and cell cycle regulation
Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents
Ewing's sarcoma accounts for a disproportionately high portion of the overall pediatric mortality rate compared to its rare incidence in the pediatric population. Little progress has been made since the introduction of traditional chemotherapies, and understanding the biology of the tumor is critical for developing new therapies. Ewing's sarcomas rely on a functional vascular supply, which is formed by a combination of angiogenesis and vasculogenesis. Recent insights into the molecular regulation of bone marrow (BM) cell participation in vascular development have identified VEGF, SDF-1Îą, and DLL4 as critical players in the vasculogenesis process. Clinical trials using vascular targeting agents, specifically targeting VEGF or DLL4, are underway
Complete intersections and mod p cochains
We give homotopy invariant definitions corresponding to three well known
properties of complete intersections, for the ring, the module theory and the
endomorphisms of the residue field, and we investigate them for the mod p
cochains on a space, showing that suitable versions of the second and third are
equivalent and that the first is stronger. We are particularly interested in
classifying spaces of groups, and we give a number of examples.
This paper follows on from arXiv:0906.4025 which considered the classical
case of a commutative ring and arXiv:0906.3247 which considered the case of
rational homotopy theory.Comment: To appear in AG
- âŚ