Dynamic demand management and online tour planning for same-day delivery

For providers to stay competitive in a context of continued growth in e-retail sales and increasing customer expectations, same-day delivery options have become very important. Typically, with same-day delivery, customers purchase online and expect to receive their ordered goods within a narrow delivery time span. Providers thus experience substantial operational challenges to run profitable tours and generate sufficiently high contribution margins to cover overhead costs. We address these challenges by combining a demand-management approach with an online tour-planning approach for same-day delivery. More precisely, in order to reserve capacity for high-value customer orders and to guide customer choices toward efficient delivery operations, we propose a demand-management approach that explicitly optimizes the combination of delivery spans and prices which are presented to each incoming customer request. The approach includes an anticipatory sample-scenario based value approximation, which incorporates a direct online tour-planning heuristic. It does not require extensive offline learning and is scalable to realistically sized instances with multiple vehicles. In a comprehensive computational study, we show that our anticipatory approach can improve the contribution margin by up to 50% compared to a myopic benchmark approach. We also show that solving an explicit pricing optimization problem is a beneficial component of our approach. More precisely, it outperforms both a pure availability control and a simple pricing rule based on opportunity costs. The latter idea is one used in other approaches for related dynamic pricing problems dealt with in the literature

Assessment of Herd, Calf, and Colostrum Management Practices on Austrian Dairy Farms Using a Scoring System

The objectives of the study were to describe colostrum management on Austrian dairy farms and to explore differences between regions (alpine/flatlands), organic and conventional producing farms, and full-time or part-time operated farms. An online survey (24 questions) on general farm characteristics and herd and calf management was sent to 16,246 farmers. In total, 2328 farmers (response rate 14.3%) answered the questionnaire. To allow an objective comparison, a scoring system was implemented. Farm size is, on average, smaller in the alpine regions than in the foothills/flatlands regions of Austria. Small farms were more often organic-producing farms (81.6%) and operated part-time (93.8%). In foothills/flatland regions, 70.0% of farms have a separate calving area, and in the alpine regions, it is solely 42.8%. Colostrum testing is still mostly done by visual appraisal (63.7%); only a few farmers use a colostrometer (8.8%), brix-refractometer (18.3%), or ColostroCheck® (9.2%, a cone-shaped device to rate the flow velocity of colostrum). The results of the present study using the scoring system showed differences in herd and calf management practices in all sectors. In the future, the findings and especially the scoring system can support Austrian dairy farmers or veterinarians to better assess areas of improvement on farms in order to prevent calves from suffering from Failure of Transfer of Passive Immunity

Immune-stimulating effects of lactic acid bacteria in vivo and in vitro.

The health-promoting effects of lactic acid bacteria (LAB) are well recognised, making them a popular functional food ingredient. Commercially available probiotic products are often promoted as capable of improving immune defences also in healthy subjects. However, while strain-specific differences exist in the effects of LAB, conventional yoghurt bacteria have proved beneficial as well. For comparing the immunological effects of conventional and probiotic LAB, young healthy women received either a commercially available probiotic fermented milk product or a conventional yoghurt for four weeks. Both treatments showed comparable effects resulting in a stronger immunological reaction to stimuli (natural cytotoxicity against cancer cells, mitogen-induced T-lymphocyte activation and stimulated cytokine production). To study the mechanisms behind these effects, conventional (Lactobacillus delbrueckii) and probiotic (Lactobacillus rhamnosus GG), LAB were compared in vitro at the cellular level. Interestingly, L. rhamnosus GG was more potent in inducing maturation of dendritic cells (DC) that play a substantial role in directing the immune response to stimuli. In turn, L. delbrueckii provoked a higher secretion of proinflammatory cytokines as well as IL-10. These effects were, however, observed only after direct incubation of DC and LAB, not when both were separated by a layer of enterocyte-like Caco-2 cells. LAB also induced cytokine secretion in peripheral blood mononuclear cells in a similar manner and this effect was reduced in a Caco-2 cell model, suggesting a modulating influence of gut epithelial cells. While both conventional and probiotic strains modulate the immune response, specific properties may offer therapeutic options in the treatment of certain diseases

Fire prevention in Ottoman and Habsburg building codes for Bosnia and their application in Travnik

The city of Travnik, located in central Bosnia, served as an administrative center of the Ottoman province between 1699 and 1851, with only short interruptions. In 1878, the Congress of Berlin awarded the Austro‐Hungarian Monarchy rights of occupation for this Ottoman province. The following year, the new administration already faced its first big fire, which wiped out a major part of downtown Sarajevo. A new building code, which tried to minimize future hazard risks and was soon valid for all of Bosnia, was established in 1880. In September 1903, two major fires hit Travnik. The Ottoman administrative building used by the new officials was already fire‐improved, so it survived the fires without sustaining any serious damage. The same cannot be said for the traditional residential neighborhoods at the foot of Travnik castle, which burnt down to their foundations. The mosques in Travnik that were constructed mostly of wood were damaged severely. Austro‐Hungarian administration officials identified the traditional way of building as a serious risk for all of Bosnia and tried to counterbalance by implementing the new regulations rigidly in their post‐fire reconstruction program. They seem to have developed a more secure ‘mosque building model type’, which they implemented in the re‐erection of the Lončarica, Zulići, Kahvica and Šumećka mosques. While rebuilding the Varoška and Lukačka mosques, the distinct ‘official’ style of Habsburg‐Bosnia, a blend of various architectural elements associated with ‘the Orient’ that the literature tends to name ‘pseudo‐Moorish’, was used

Decreased expression of endogenous feline leukemia virus in cat lymphomas: a case control study

Background: Cats infected with exogenous feline leukemia virus (exFeLV) have a higher chance of lymphoma development than uninfected cats. Furthermore, an increased exFeLV transcription has been detected in lymphomas compared to non-malignant tissues. The possible mechanisms of lymphoma development by exFeLV are insertional mutagenesis or persistent stimulation of host immune cells by viral antigens, bringing them at risk for malignant transformation. Vaccination of cats against exFeLV has in recent years decreased the overall infection rate in most countries. Nevertheless, an increasing number of lymphomas have been diagnosed among exFeLV-negative cats. Endogenous feline leukemia virus (enFeLV) is another retrovirus for which transcription has been observed in cat lymphomas. EnFeLV provirus elements are present in the germline of various cat species and share a high sequence similarity with exFeLV but, due to mutations, are incapable of producing infectious viral particles. However, recombination between exFeLV and enFeLV could produce infectious particles. Results: We examined the FeLV expression in cats that have developed malignant lymphomas and discussed the possible mechanisms that could have induced malignant transformation. For expression analysis we used next-generation RNA-sequencing (RNA-Seq) and for validation reverse transcription quantitative PCR (RT-qPCR). First, we showed that there was no expression of exFeLV in all samples, which eliminates the possibility of recombination between exFeLV and enFeLV. Next, we analyzed the difference in expression of three enFeLV genes between control and lymphoma samples. Our analysis showed an average of 3.40-fold decreased viral expression for the three genes in lymphoma compared to control samples. The results were confirmed by RT-qPCR. Conclusions: There is a decreased expression of enFeLV genes in lymphomas versus control samples, which contradicts previous observations for the exFeLV. Our results suggest that a persistent stimulation of host immune cells is not an appropriate mechanism responsible for malignant transformation caused by feline endogenous retroviruses

Asymptotic arbitrage in fractional mixed markets

We consider a family of mixed processes given as the sum of a fractional Brownian motion with Hurst parameter H∈(3/4,1) and a multiple of an independent standard Brownian motion, the family being indexed by the scaling factor in front of the Brownian motion. We analyze the underlying markets with methods from large financial markets. More precisely, we show the existence of a strong asymptotic arbitrage (defined as in Kabanov and Kramkov [Finance Stoch. 2(2), 143–172 (1998)]) when the scaling factor converges to zero. We apply a result of Kabanov and Kramkov [Finance Stoch. 2(2), 143–172 (1998)] that characterizes the notion of strong asymptotic arbitrage in terms of the entire asymptotic separation of two sequences of probability measures. The main part of the paper consists of proving the entire separation and is based on a dichotomy result for sequences of Gaussian measures and the concept of relative entropy.© 2018 The Author(s