Introducing Older Persons to Benefits of Technology - Report Series # 2

Social isolation is an often-cited deterrent to a high quality of life for older persons. This qualitative study, conducted in the fall of 2003, attempted to link generations and decrease social isolation by providing seniors with instruction on computer and Internet use. Eight participants aged 65-73 met weekly to participate in computer classes facilitated by a teacher and a peer. Evaluation methods included self-evaluation, questionnaires, and research field notes. Barriers to computer use identified by older adults in this study included: lack of access, intimidation, lack of training, and lack of time. All participants rated themselves as somewhat skillful following the training provided and all identified computer skills as being indispensable to older adults. Participants rated the training provided in this pilot as useful and identified hopes that further training would be provided at the Sheridan Elder Research Centre (SERC). The pilot successfully demonstrated the areas that require further research in the area of technology applications for older adults while providing hands-on training to a small sample of interested seniors

Sign Comprehension in Young Adults, the Healthy Elderly, and Older People with Varying Levels of Cognitive Impairment - Report Series # 5

This study, conducted in the fall of 2004 and the winter of 2005, sought to determine whether sign comprehension suffers in healthy aging and in the presence of cognitive impairment. Sign comprehension is critical for effective driving, response to warnings and way-finding. If signs are poorly comprehended by older people including those with cognitive impairment, accident risk will be increased and independence may be compromised. Groups of young adults, healthy older adults and older adults with varying levels of cognitive impairment were asked the meaning of 65 signs used for driving, warning and way-finding. Healthy older adults were generally good at sign comprehension, but had some difficulty with way-finding signs. Older adults with cognitive impairments had poorer sign comprehension overall and were particularly poor with way-finding signage. Testing of sign comprehension needs to involve a more heterogeneous sampling of older adults. As well, signs that include text would be beneficial to those with cognitive impairment

Unpuzzling COVID-19:Tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses - the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - discovered in December 2019 in the city of Wuhan (Hubei Province, China). Remarkably, COVID-19 has rapidly spread across all continents and turned into a public health emergency, which was ultimately declared as a pandemic by the World Health Organization (WHO) in early 2020. SARS-CoV-2 presents similar aspects to other members of the coronavirus family, mainly regarding its genome, protein structure and intracellular mechanisms, that may translate into mild (or even asymptomatic) to severe infectious conditions. Although the mechanistic features underlying the COVID-19 progression have not been fully clarified, current evidence have suggested that SARS-CoV-2 may primarily behave as other β-coronavirus members. To better understand the development and transmission of COVID-19, unveiling the signaling pathways that may be impacted by SARS-CoV-2 infection, at the molecular and cellular levels, is of crucial importance. In this review, we present the main aspects related to the origin, classification, etiology and clinical impact of SARS-CoV-2. Specifically, here we describe the potential mechanisms of cellular interaction and signaling pathways, elicited by functional receptors, in major targeted tissues/organs from the respiratory, gastrointestinal (GI), cardiovascular, renal, and nervous systems. Furthermore, the potential involvement of these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these organ systems are presently discussed. A brief description of future perspectives related to potential COVID-19 treatments is also highlighted

Dynamics of mother-pup interactions: tradeoff between environment and physiology

The emergence and maintenance of maternal behavior are under the influence of environmental cues such as light and dark periods. This article discusses the characteristic neurobiology of the behavioral patterns of lactating rats. Specifically, the hormonal basis and neurocircuits that determine whether mother rats show typical sequential patterns of behavioral responses are discussed. During lactation, rats express a sequential pattern of behavioral parameters that may be determined by hormonal variations. Sensorial signals emitted by pups, as well as environmental cues, are suggested to serve as conditioned stimuli for these animals. Finally, the expression of maternal behavior is discussed under neuroeconomic and evolutionary perspectives

Adolescent Medicine at the Crossroads: A Review of Fellowship Training and Recommendations for Reform

This report examines the current state of adolescent medicine fellowship programs -- including the supply and recruitment of fellows; the nature and content of clinical, research, and leadership training; and the institutional and financial challenges facing training programs today -- and offers recommendations for building the field. The report is based on findings from the first comprehensive national survey of adolescent medicine fellowship program directors, conducted in the spring of 2007 by Incenter Strategies. The document also presents selected findings from two other Incenter Strategies’ surveys conducted in 2007: one of pediatric residency program directors and the other of adolescent medicine faculty responsible for the one-month pediatric residency rotation. In addition, the report presents findings from key informant interviews and an extensive literature review

Low grade mosaic for a complex supernumerary ring chromosome 18 in an adult patient with multiple congenital anomalies

Background. Several cases have been reported of patients with a ring chromosome 18 replacing one of the normal chromosomes 18. Less common are patients with a supernumerary ring chromosomes 18. High resolution whole genome examination in patients with multiple congenital abnormalities might reveal cytogenetic abnormalities of an unexpected complexity. Results. We report a 24 years old male patient with lower spinal anomalies, hypospadia, bifid scrotum, cryptorchism, anal atresia, kidney stones, urethra anomalies, radial dysplasia, and a hypoplastic thumb. Some of the anomalies overlap with the VACTERL association. Chromosome analysis of cultured peripheral blood lymphocytes revealed an additional ring chromosome in 13% of the metaphases. Both parents had a normal karyotype, demonstrating the de novo origin of this ring chromosome. FISH analysis using whole chromosome paints showed that the additional chromosomal material was derived from chromosome 18. Chromosome analysis of cultured fibroblasts revealed only one cell with the supernumerary ring chromosome in the 400 analyzed. To characterize the ring chromosome in more detail peripheral blood derived DNA was analyzed using SNP-arrays. The array results indicated a 5 Mb gain of the pericentromeric region of chromosome 18q10-q11.2. FISH analysis using BAC-probes located in the region indicated the presence of 6 signals on the r(18) chromosome. In addition, microsatellite analysis demonstrated that the unique supernumerary ring chromosome was paternally derived and both normal copies showed biparental disomy. Conclusions. We report on an adult patient with multiple congenital abnormalities who had in 13% of his cells a unique supernumerary ring chromosome 18 that was composed of 6 copies of the 5 Mb gene rich region of 18q11