2,218 research outputs found
Abiotic methane synthesis and serpentinization in olivine-hosted fluid inclusions
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Proceedings of the National Academy of Sciences.of the United States of America 116(36), (2019): 17666-17672. doi:10.1073/pnas.1907871116.The conditions of methane (CH4) formation in olivine-hosted secondary fluid inclusions and their prevalence in peridotite and gabbroic rocks from a wide range of geological settings were assessed using confocal Raman spectroscopy, optical and scanning electron microscopy, electron microprobe analysis, and thermodynamic modeling. Detailed examination of 160 samples from ultraslow- to fast-spreading midocean ridges, subduction zones, and ophiolites revealed that hydrogen (H2) and CH4 formation linked to serpentinization within olivine-hosted secondary fluid inclusions is a widespread process. Fluid inclusion contents are dominated by serpentine, brucite, and magnetite, as well as CH4(g) and H2(g) in varying proportions, consistent with serpentinization under strongly reducing, closed-system conditions. Thermodynamic constraints indicate that aqueous fluids entering the upper mantle or lower oceanic crust are trapped in olivine as secondary fluid inclusions at temperatures higher than ∼400 °C. When temperatures decrease below ∼340 °C, serpentinization of olivine lining the walls of the fluid inclusions leads to a near-quantitative consumption of trapped liquid H2O. The generation of molecular H2 through precipitation of Fe(III)-rich daughter minerals results in conditions that are conducive to the reduction of inorganic carbon and the formation of CH4. Once formed, CH4(g) and H2(g) can be stored over geological timescales until extracted by dissolution or fracturing of the olivine host. Fluid inclusions represent a widespread and significant source of abiotic CH4 and H2 in submarine and subaerial vent systems on Earth, and possibly elsewhere in the solar system.We are indebted to J. Eckert for his support with FE-EMPA; to K. Aquinho and E. Codillo for providing samples from Zambales; to K. Aquinho for Raman analysis of some of the samples from Zambales and Mt. Dent; to H. Dick for providing access to his thin section collection; to the curators of the IODP core repositories for providing access to Ocean Drilling Program (ODP) and Integrated Ocean Drilling Program (IODP) samples; and to the captains and crews of the many cruises without whom the collection of these samples would not have been possible. Reviews by Peter Kelemen and an anonymous referee greatly improved this manuscript. This study is supported with funds provided by the National Science Foundation (NSF-OCE Award 1634032 to F.K. and J.S.S.).2020-02-1
Quantum mechanics is about quantum information
I argue that quantum mechanics is fundamentally a theory about the
representation and manipulation of information, not a theory about the
mechanics of nonclassical waves or particles. The notion of quantum information
is to be understood as a new physical primitive -- just as, following
Einstein's special theory of relativity, a field is no longer regarded as the
physical manifestation of vibrations in a mechanical medium, but recognized as
a new physical primitive in its own right.Comment: 17 pages, forthcoming in Foundations of Physics Festschrift issue for
James Cushing. Revised version: some paragraphs have been added to the final
section clarifying the argument, and various minor clarifying remarks have
been added throughout the tex
Bacterial Vaginosis and the Natural History of Human Papillomavirus
Objective. To evaluate associations between common vaginal infections and human papillomavirus (HPV). Study Design. Data from up to 15 visits on 756 HIV-infected women and 380 high-risk HIV-uninfected women enrolled in the HIV Epidemiology Research Study (HERS) were evaluated for associations of bacterial vaginosis, trichomoniasis, and vaginal Candida colonization with prevalent HPV, incident HPV, and clearance of HPV in multivariate analysis. Results. Bacterial vaginosis (BV) was associated with increased odds for prevalent (aOR = 1.14, 95% CI: 1.04, 1.26) and incident (aOR = 1.24, 95% CI: 1.04, 1.47) HPV and with delayed clearance of infection (aHR = 0.84, 95% CI: 0.72, 0.97). Whereas BV at the preceding or current visit was associated with incident HPV, in an alternate model for the outcome of incident BV, HPV at the current, but not preceding, visit was associated with incident BV. Conclusion. These findings underscore the importance of prevention and successful treatment of bacterial vaginosis
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
BACKGROUND: Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse elimination within the hippocampus. Moreover, CNS-resident memory T (T
METHODS: Here, we examined immune cells within the murine WNV-recovered forebrain using single-cell RNA sequencing to identify putative ligand-receptor pairs involved in intercellular communication between T cells and microglia. Clustering and differential gene analyses were followed by protein validation and genetic and antibody-based approaches utilizing an established murine model of WNV recovery in which microglia and complement promote ongoing hippocampal synaptic loss.
RESULTS: Profiling of host transcriptome immune cells at 25 days post-infection in mice revealed a shift in forebrain homeostatic microglia to activated subpopulations with transcriptional signatures that have previously been observed in studies of neurodegenerative diseases. Importantly, CXCL16/CXCR6, a chemokine signaling pathway involved in T
CONCLUSIONS: We provide a comprehensive assessment of the role of CXCL16/CXCR6 as an interaction link between microglia and CD
A mouse model for HIV-1 entry
Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody’s ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions
Evidence for an FU Orionis-like Outburst from a Classical T Tauri Star
We present pre- and post-outburst observations of the new FU Orionis-like
young stellar object PTF 10qpf (also known as LkHa 188-G4 and HBC 722). Prior
to this outburst, LkHa 188-G4 was classified as a classical T Tauri star on the
basis of its optical emission-line spectrum superposed on a K8-type
photosphere, and its photometric variability. The mid-infrared spectral index
of LkHa 188-G4 indicates a Class II-type object. LkHa 188-G4 exhibited a steady
rise by ~1 mag over ~11 months starting in Aug. 2009, before a subsequent more
abrupt rise of > 3 mag on a time scale of ~2 months. Observations taken during
the eruption exhibit the defining characteristics of FU Orionis variables: (i)
an increase in brightness by > 4 mag, (ii) a bright optical/near-infrared
reflection nebula appeared, (iii) optical spectra are consistent with a G
supergiant and dominated by absorption lines, the only exception being Halpha
which is characterized by a P Cygni profile, (iv) near-infrared spectra
resemble those of late K--M giants/supergiants with enhanced absorption seen in
the molecular bands of CO and H_2O, and (v) outflow signatures in H and He are
seen in the form of blueshifted absorption profiles. LkHa 188-G4 is the first
member of the FU Orionis-like class with a well-sampled optical to mid-infrared
spectral energy distribution in the pre-outburst phase. The association of the
PTF 10qpf outburst with the previously identified classical T Tauri star LkHa
188-G4 (HBC 722) provides strong evidence that FU Orionis-like eruptions
represent periods of enhanced disk accretion and outflow, likely triggered by
instabilities in the disk. The early identification of PTF 10qpf as an FU
Orionis-like variable will enable detailed photometric and spectroscopic
observations during its post-outburst evolution for comparison with other known
outbursting objects.Comment: 14 pages, 11 figures, ApJ accepte
On the Quantum Invariant for the Spherical Seifert Manifold
We study the Witten--Reshetikhin--Turaev SU(2) invariant for the Seifert
manifold where is a finite subgroup of SU(2). We show
that the WRT invariants can be written in terms of the Eichler integral of the
modular forms with half-integral weight, and we give an exact asymptotic
expansion of the invariants by use of the nearly modular property of the
Eichler integral. We further discuss that those modular forms have a direct
connection with the polyhedral group by showing that the invariant polynomials
of modular forms satisfy the polyhedral equations associated to .Comment: 36 page
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