Radiotherapy and angiogenesis inhibition: From bench to bedside

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Local probing of coupled interfaces between two-dimensional electron and hole gases in oxide heterostructures by variable-temperature scanning tunneling spectroscopy

The electronic structure of an epitaxial oxide heterostructure containing two spatially separated two-dimensional conducting sheets, one electronlike (2DEG) and the other holelike (2DHG), has been investigated using variable temperature scanning tunneling spectroscopy. Heterostructures of LaAlO3/SrTiO3 bilayers on (001)-oriented SrTiO3 (STO) substrates provide the unique possibility to study the coupling between subnanometer spaced conducting interfaces. The band gap increases dramatically at low temperatures due to a blocking of the transition from the conduction band of the STO substrate to the top of the valence band of the STO capping layer. This prevents the replenishment of the depleted electrons in the capping layer from the underlying 2DEG and enables charging of the 2DHG by applying a negative sample bias voltage within the band gap region. At low temperatures the 2DHG can be probed separately with the proposed experimental geometry, although the 2DEG is located less than 1 nm belo

What Box?': behavioral, neuro-imaging, and training studies on the development of creative cognition in adolescence

This thesis focused on the development of creative thinking across adolescence and into adulthood. To this end, a range of creativity tasks, both with and without an fMRI scanner, and before and after training paradigms has been used to ex_amine both age- and experience-related effects on creative thinking performance during functional brain develop_ment. Chapter 1 provides a theoretical background for the research described in chapters 2 to 6. In Chapter 2, developmental trajectories of creative cognition across adolescence and early adulthood were examined using a set of tasks gauging both insight and divergent thinking in the verbal and visual domain. In Chapter 3, behavioral and neural differences for creative problem solving in middle-adolescents and adults were examined. Chapter 4 examined the neural correlates of divergent thinking in adults and adolescents. Chapter 5 focused on the effectiveness of creative ideation training in adolescents and adults. In Chapter 6, the benefits of training creativity in adolescents were examined using fMRI techniques. Finally, Chapter 7 summarizes the main results of the empirical studies presented in this thesis. Here, implications of the results are discussed and suggestions for future research are presented.Pathways through Adolescenc