Effect of haloperidol on the development of the solid Ehrlich tumor in mice

We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol (s.c) on the development of the Ehrlich solid carcinoma, after inoculation of 1.5 x 10(6) Ehrlich ascites tumor cells into the left footpad of mice. the footpad thickness of haloperidol treated animals was significantly smaller than control from day two after tumor inoculation, to the end of the experiment. Histopathological examination showed that haloperidol treated mice apparently presented less necrotic areas within the tumor mass as well as less invasion of subepithelial connective tissue and other adjacent structures. in particular, in comparison with the control group, no nerve bundles were invaded by neoplastic cells in experimental mice. the possible mechanism underlying these results is discussed in light of the specific pharmacological properties of this neuroleptics drug.USP,FAC MED VET & ZOOTECN,DEPT PATOL,BR-05508900 São Paulo,BRAZILUNIFESP,ESCOLA PAULISTA MED,DEPT PHARMACOL,São Paulo,BRAZILUNIFESP,ESCOLA PAULISTA MED,DEPT PHARMACOL,São Paulo,BRAZILWeb of Scienc

Haloperidol increases spreading and nitric oxide production in macrophages from tumor-bearing mice: a possible mechanism for its antitumoral effect

Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase both the percent of macrophage spreading and nitric oxide (NO) release in peritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10(6) Ehrlich ascites cells. This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma. (C) 1999 International Society for Immunopharmacology, Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniv São Paulo, Fac Med Vet & Zootecnia, Dept Patol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilWeb of Scienc