Characteristics of study participants at baseline in the EPIC-Potsdam subsample.

<p>SD = Standard deviation.</p

Associations of the MSR-selected SNP combinations with obesity-related traits in 2,122 European middle-aged men and women (random population sample).

<p>Association results are based on models adjusted for sex, age, education, occupational activity, sports activity, smoking, and alcohol, energy, fat, fruit and vegetable intake. SE = standard error.</p>a<p>Permutation test based on 200 permutations.</p>b<p>SNP ID numbers according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068941#pone-0068941-t002" target="_blank">Table 2</a>.</p>c<p>The major allele was coded as 1 and the minor one as 2.</p

SNP characteristics and associations of SNP alleles with obesity-related traits in 2,122 European middle-aged men and women (random population sample).

<p>ID = identification number, WC = waist circumference, MAF = minor allele frequency, HWE = Hardy Weinberg equilibrium, SE = Standard error, N = Number of individuals.</p>a<p>p-value of exact HWE test.</p>b<p>Results of multiple linear regression analyses adjusted for sex, age, education, occupational activity, smoking, and alcohol, energy, fat, fruit and vegetable intake. SNPs were included in the models coded as 0, 1, 2 for minor allele count.</p

Results of the transmission disequilibrium test.

<p>Results of the transmission disequilibrium test.</p

Comparison of the MCG and Imprinting models with the full model.

<p>Comparison of the MCG and Imprinting models with the full model.</p

Parent-of-origin analysis of the combined <i>FLG</i> mutations.

<p>Parent-of-origin analysis of the combined <i>FLG</i> mutations.</p

Study populations.

<p>Study populations.</p

Frequency of FLG mutations in fathers, mothers, individuals with atopic dermatitis and controls.

<p>Allele and genotype frequencies of the combined <i>FLG</i>-mutations in fathers and mothers were calculated using all available parents. AD refers to the frequency in the AD-affected children including the families and the unrelated AD-cases (available only in the Central European study). Frequency in controls corresponds to population-based individuals with unknown disease status. Results of the Central and Northern European populations are shown in panels A and B, respectively.</p

Parent-of-origin-analysis analysis stratified by maternal specific sensitization.

<p>Parent-of-origin-analysis analysis stratified by maternal specific sensitization.</p