Additional file 1 of Impact of a complex health services intervention in long-term care nursing homes on 3-year overall survival: results from the CoCare study

Supplementary material

Additional file 2: Table S2. of Two-year post-discharge costs of care among patients treated with transcatheter or surgical aortic valve replacement in Germany

Two year monthly cost estimates of patients treated for aortic valve stenosis (including also patients receiving drug-based therapy). Separate two-part models, with one (only time: month 1 vs. month 2–24, or month 1–12 vs month 13–24) or two (time and sex or procedure or ...) categorical covariates are conducted with a logistic regression analysis for part one and a generalised linear model with the log link and gamma distribution for the second part. Marginal effects for the combined models are shown on the raw scale (€ per month). 95% confidence intervals in brackets. All estimates reflect cost estimates in Euro (basis year 2011) from a societal perspective. (DOCX 25 kb

Additional file 1: Table S1. of Two-year post-discharge costs of care among patients treated with transcatheter or surgical aortic valve replacement in Germany

Marginal effects for the two parts of the two-part model separately. Marginal effects are shown for the two parts of the two-part model separately. As shown in Table 2, two-part models with one (time: month 1 vs. month 2–24, or month 1–12 vs month 13–24) or two (time and sex or procedure or ...) categorical covariates are conducted with a logistic regression analysis for part one and a generalised linear model with the log link and gamma distribution for the second part. Marginal effects for the combined models are shown on the raw scale (€ per month). 95% confidence intervals in brackets. All estimated prices reflect cost estimates in Euro (basis year 2011) from a societal perspective. (DOCX 38 kb

Is serum level of CC chemokine ligand 18 a biomarker for the prediction of radiation induced lung toxicity (RILT)?

<div><p>The CC chemokine ligand 18 (CCL18) is produced by alveolar macrophages in patients with fibrosing lung disease and its concentration is increased in various fibrotic lung diseases. Furthermore CCL18 is elevated in several malignancies as it is produced by tumor associated macrophages. In this study we aimed to analyze the role of CCL18 as a prognostic biomarker for the development of early radiation induced lung toxicity (RILT), i.e. radiation pneumonitis after thoracic irradiation and its significance in the course of the disease. Sixty seven patients were enrolled prospectively in the study. Patients were treated with irradiation for several thoracic malignancies (lung cancer, esophageal cancer, thymoma), either with conventionally fractionated or hypo-fractionated radiotherapy. The CCL18 serum levels were quantified with ELISA (enzyme-linked immunosorbent assay) at predefined time points: before, during and at the end of treatment as well as in the first and second follow-up. Treatment parameters and functional tests were also correlated with the development of RILT.Fifty three patients were evaluable for this study. Twenty one patients (39%) developed radiologic signs of RILT Grade >1 but only three of them (5.6%) developed clinical symptoms (Grade 2). We could not find any association between the different CCL18 concentrations and a higher incidence of RILT. Statistical significant factors were the planning target volume (odds ratio OR: 1.003, p = 0.010), the volume of the lung receiving > 20 Gy (OR: 1.132 p = 0.004) and age (OR: 0.917, p = 0.008). There was no association between serial CCL18 concentrations with tumor response and overall survival.In our study the dosimetric parameters remained the most potent predictors of RILT. Further studies are needed in order to estimate the role of CCL18 in the development of early RILT.</p></div

Individual trajectories of CCL18, local recurrence and distant metastases in patients with RILT.

<p>Individual trajectories of CCL18, local recurrence and distant metastases in patients with RILT.</p