Impact of COVID-19 on Mental Health of Oncology Healthcare Workers and Interdisciplinary Collaboration

The 2019 coronavirus pandemic has caused serious health crises around the world such as psychological reactions of health workers. The way we work (stress, anxiety) and the activities assigned to pharmacists, such as vaccination, have changed. In addition to these problems, numerous ethical questions and moral doubts are increasingly emerging are inevitable during the treatment and care of patients in this extremely difficult situation. Work in the oncology department is stressful even when there is no epidemic/pandemic. Constant changes in hospital protocols, reorganization of work, influx of patients, work in intensive conditions and other new challenges of adaptation to the new situation affect both the physical and mental health of healthcare workers. Together with physicians and nurses, pharmacists were one of the professional categories most exposed to the risk of SARS- CoV-2 infection since the pandemic onset. Together with this crisis, pharmaceutical care entered a new phase demonstrating the ability of pharmacists to be competent and accessible providers of public health. Preserving the mental health of healthcare workers are very important so that they can perform their work with quality and conscientiousness. Health care corporations should consider providing coverage for mental health treatment for employees who experience COVID-19 traumas

VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes

Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms

A Novel Method for Quantifying Shape Deformation Applied to Biocompatibility Testing

Cytotoxicity tests are important for the screening and evaluation of biocompatibility of artificial organs. Morphological changes of cells which were contacted to biomaterials or biomaterial extracts indicate their toxicity. However, information on cytotoxical effects is still obtained by subjective visual inspection of microscopic samples. In thi

Effect of butorphanol, midazolam or ketamine on romifidine based sedation in horses during standing cheek tooth removal

Abstract Background Standing surgery, especially dental procedures, are commonly performed in horses. This leads to an increasing demand for reliable sedation protocols. Therefore, it was the purpose of this study to investigate the influence of butorphanol, midazolam or ketamine on romifidine based sedation in horses during cheek tooth removal. Methods Forty horses presented for tooth extraction were divided in four groups using matched pair randomization. Group R was sedated with romifidine (bolus 0.03 mg/kg, followed by a constant rate infusion (CRI) 0.05 mg/kg/h) and group RB with romifidine (same dose) and butorphanol (0.02 mg/kg; CRI 0.04 mg/kg/h). Group RM received romifidine (same dose) and midazolam (0.02 mg/kg; CRI 0.06 mg/kg/h) whereas group RK was administered romifidine (same dose) and ketamine (0.5 mg/kg; CRI 1.2 mg/kg/h). If sedation was not adequate a top up bolus of romifidine (0.01 mg/kg) was administered. The quality of sedation and the conditions for tooth extraction, the level of ataxia, chewing, head and tongue movement were evaluated by using a scoring system. The investigator was blinded to the applied sedation protocol. Furthermore, serum cortisol concentrations before, during and after the procedure were analyzed to gain more information about the stress level of the horses. Results Horses in group RM showed significantly less chewing and tongue activity compared to horses sedated with romifidine alone or with butorphanol additionally, but also significantly higher levels of ataxia. The quality of sedation was significantly better if romifidine was administered in combination with ketamine compared to romifidine alone. Furthermore, horses of group RK needed less additional romifidine boli compared to all other groups. Blood cortisol concentrations during surgery in groups RB and RM remained unchanged. Horses of group R showed higher cortisol concentrations during sedation compared to horses of groups RB and RM. Conclusion Romifidine alone at an initial bolus dose of 0.03 mg/kg followed by a constant rate infusion of 0.05 mg/kg/h was insufficient to obtain an adequate level of sedation and led to increased stress levels, whereas the addition of butorphanol inhibited the stress response. The combination of romifidine with either midazolam or ketamine improved sedation quality and surgical conditions

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shape analysis for quantitative cytolog