MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice

Successful outcomes for patients with cancer often depend on the early detection of tumor and the prompt initiation of active therapy. Despite major advances in the treatment of many cancers, early-stage lesions often go undetected due to the suboptimal resolution of current anatomical and functional imaging modalities. This limitation also applies to preclinical animal tumor models that are crucial for the evaluation and development of new therapeutic approaches to cancer. We report a new mouse model of metastatic pheochromocytoma, generated using tail vein injection of the mouse pheochromocytoma cell (MPC) line that reproducibly generated multiple liver tumors in the animals. Furthermore, we show that in vivo microCT imaging enhanced using a hepatobiliary-specific contrast agent, glyceryl-2-oleyl-1,3-di- 7-(3-amino-2,4,6-triiodophenyl)-heptanoate (DHOG), detected tumors as small as 0.35 mm as early as 4 weeks after the injection of the tumor cells. This model may be useful for in vivo studies of tumor biology and for development of new strategies to treat metastatic pheochromocytoma

International record of medicine and general practice clinics.

Ibáñez.Editors: Apr. 1867-June 1871, E. S. Dunster (with W. A. Hammond, Apr. 1867-Mar. 1869) - July 1871-Dec. 1879, J. B. Hunter (with W. T. Lusk, July 1871-Dec. 1873) - Jan. 1880-Aug. 19, 1911, F. P. Foster (with S. E. Jelliffe, Jan. 1906-Oct. 1908) - Dec. 9, 1911-Jan. 18, 1919, C. E. de M. Sajous (with C. L. Wheeler, Nov. 29, 1913-Jan. 6, 1917, S. E. Jelliffe, Feb. 24, 1917-Jan. 18, 1919) - May 1922- G. Stragnell. - -Dec. 1950, H. J. Klaunberg. - Jan. 1951- F. MartíOther slight variations in title.Mode of access: Internet.Issues for Nov. 1949-Feb. 1953 published by the Washington Institute of Medicine

Imaging preclinical tumour models: improving translational power

Recent developments and improvements of multimodal imaging methods for use in animal research have substantially strengthened the options of in vivo visualization of cancer-related processes over time. Moreover, technological developments in probe synthesis and labelling have resulted in imaging probes with the potential for basic research, as well as for translational and clinical applications. In addition, more sophisticated cancer models are available to address cancer-related research questions. This Review gives an overview of developments in these three fields, with a focus on imaging approaches in animal cancer models and how these can help the translation of new therapies into the clinic