The Relative Space: Space Measurements on a Rotating Platform

We introduce here the concept of relative space, an extended 3-space which is recognized as the only space having an operational meaning in the study of the space geometry of a rotating disk. Accordingly, we illustrate how space measurements are performed in the relative space, and we show that an old-aged puzzling problem, that is the Ehrenfest's paradox, is explained in this purely relativistic context. Furthermore, we illustrate the kinematical origin of the tangential dilation which is responsible for the solution of the Ehrenfest's paradox.Comment: 14 pages, 2 EPS figures, LaTeX, to appear in the European Journal of Physic

Reference frames and rigid motions in relativity: Applications

The concept of rigid reference frame and of constricted spatial metric, given in the previous work [\emph{Class. Quantum Grav.} {\bf 21}, 3067,(2004)] are here applied to some specific space-times: In particular, the rigid rotating disc with constant angular velocity in Minkowski space-time is analyzed, a new approach to the Ehrenfest paradox is given as well as a new explanation of the Sagnac effect. Finally the anisotropy of the speed of light and its measurable consequences in a reference frame co-moving with the Earth are discussed.Comment: 13 pages, 1 figur

Relativistic contraction and related effects in noninertial frames

Although there is no relative motion among different points on a rotating disc, each point belongs to a different noninertial frame. This fact, not recognized in previous approaches to the Ehrenfest paradox and related problems, is exploited to give a correct treatment of a rotating ring and a rotating disc. Tensile stresses are recovered, but, contrary to the prediction of the standard approach, it is found that an observer on the rim of the disc will see equal lengths of other differently moving objects as an inertial observer whose instantaneous position and velocity are equal to that of the observer on the rim. The rate of clocks at various positions, as seen by various observers, is also discussed. Some results are generalized for observers arbitrarily moving in a flat or a curved spacetime. The generally accepted formula for the space line element in a non-time-orthogonal frame is found inappropriate in some cases. Use of Fermi coordinates leads to the result that for any observer the velocity of light is isotropic and is equal to $c$, providing that it is measured by propagating a light beam in a small neighborhood of the observer.Comment: 15 pages, significantly revised version, title changed, to appear in Phys. Rev.

On the experimental determination of the one-way speed of light

In this contribution the question of the isotropy of the one-way speed of light from an experimental perspective is addressed. In particular, we analyze two experimental methods commonly used in its determination. The analysis is aimed at clarifying the view that the one-way speed of light cannot be determined by techniques in which physical entities close paths. The procedure employed here will provide epistemological tools such that physicists understand that a direct measurement of the speed not only of light but of any physical entity is by no means trivial. Our results shed light on the physics behind the experiments which may be of interest for both physicists with an elemental knowledge in special relativity and philosophers of science.Comment: 8 pages, 5 figures. To appear in the European Journal of Physic

Locality hypothesis and the speed of light

The locality hypothesis is generally considered necessary for the study of the kinematics of non-inertial systems in special relativity. In this paper we discuss this hypothesis, showing the necessity of an improvement, in order to get a more clear understanding of the various concepts involved, like coordinate velocity and standard velocity of light. Concrete examples are shown, where these concepts are discussed.Comment: 23 page

Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions

The perceived difficulty of the scale-up of photochemistry is one of the main obstacles preventing its widespread use. Herein, we take three different challenging reactions and show that they can be reliably scaled, from immersion well batch reactors to higher power FEP flow reactors. Key to the success has been the development of a powerful calculation methodology which enables the accurate calculation of reactor flow rates from these and previously optimised batch reactions. Despite the challenging nature of these systems, in all cases tens of grams of material was obtained

Simultaneity and generalized connections in general relativity

Stationary extended frames in general relativity are considered. The requirement of stationarity allows to treat the spacetime as a principal fiber bundle over the one-dimensional group of time translations. Over this bundle a connection form establishes the simultaneity between neighboring events accordingly with the Einstein synchronization convention. The mathematics involved is that of gauge theories where a gauge choice is interpreted as a global simultaneity convention. Then simultaneity in non-stationary frames is investigated: it turns to be described by a gauge theory in a fiber bundle without structure group, the curvature being given by the Fr\"olicher-Nijenhuis bracket of the connection. The Bianchi identity of this gauge theory is a differential relation between the vorticity field and the acceleration field. In order for the simultaneity connection to be principal, a necessary and sufficient condition on the 4-velocity of the observers is given.Comment: RevTeX, 9 pages, 2 figures, 1 table. Previous title "The gauge nature of simultaneity". Classical and Quantum Gravity http://www.iop.org/EJ/journal/CQ

The relativistic Sagnac Effect: two derivations

The phase shift due to the Sagnac Effect, for relativistic matter and electromagnetic beams, counter-propagating in a rotating interferometer, is deduced using two different approaches. From one hand, we show that the relativistic law of velocity addition leads to the well known Sagnac time difference, which is the same independently of the physical nature of the interfering beams, evidencing in this way the universality of the effect. Another derivation is based on a formal analogy with the phase shift induced by the magnetic potential for charged particles travelling in a region where a constant vector potential is present: this is the so called Aharonov-Bohm effect. Both derivations are carried out in a fully relativistic context, using a suitable 1+3 splitting that allows us to recognize and define the space where electromagnetic and matter waves propagate: this is an extended 3-space, which we call "relative space". It is recognized as the only space having an actual physical meaning from an operational point of view, and it is identified as the 'physical space of the rotating platform': the geometry of this space turns out to be non Euclidean, according to Einstein's early intuition.Comment: 49 pages, LaTeX, 3 EPS figures. Revised (final) version, minor corrections; to appear in "Relativity in Rotating Frames", ed. G. Rizzi and M.L. Ruggiero, Kluwer Academic Publishers, Dordrecht, (2003). See also http://digilander.libero.it/solciclo

Performance bounds on compressed sensing with Poisson noise

This paper describes performance bounds for compressed sensing in the presence of Poisson noise when the underlying signal, a vector of Poisson intensities, is sparse or compressible (admits a sparse approximation). The signal-independent and bounded noise models used in the literature to analyze the performance of compressed sensing do not accurately model the effects of Poisson noise. However, Poisson noise is an appropriate noise model for a variety of applications, including low-light imaging, where sensing hardware is large or expensive, and limiting the number of measurements collected is important. In this paper, we describe how a feasible positivity-preserving sensing matrix can be constructed, and then analyze the performance of a compressed sensing reconstruction approach for Poisson data that minimizes an objective function consisting of a negative Poisson log likelihood term and a penalty term which could be used as a measure of signal sparsity.Comment: 5 pages; to appear in Proc. ISIT 200

Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib

Molecular markers of sorafenib efficacy in patients with metastatic renal cell carcinoma (mRCC) are not available. The purpose of this study was to discover genetic markers of survival in patients with mRCC treated with sorafenib. Germline variants from 56 genes were genotyped in 295 patients with mRCC. Variant-overall survival (OS) associations were tested in multivariate regression models. Mechanistic studies were conducted to validate clinical associations. VEGFA rs1885657, ITGAV rs3816375, and WWOX rs8047917 (sorafenib arm), and FLT4 rs307826 and VEGFA rs3024987 (sorafenib and placebo arms combined) were associated with shorter OS. FLT4 rs307826 increased VEGFR-3 phosphorylation, membrane trafficking, and receptor activation. VEGFA rs1885657 and rs58159269 increased transcriptional activity of the constructs containing these variants in endothelial and RCC cell lines, and VEGFA rs58159269 increased endothelial cell proliferation and tube formation. FLT4 rs307826 and VEGFA rs58159269 led to reduced sorafenib cytotoxicity. Genetic variation in VEGFA and FLT4 could affect survival in sorafenib-treated patients with mRCC. These markers should be examined in additional malignancies treated with sorafenib and in other angiogenesis inhibitors used in mRCC. Significance: Clinical and mechanistic data identify germline genetic variants in VEGFA and FLT4 as markers of survival in patients with metastatic renal cell carcinoma.Peer reviewe